RecruitingNot ApplicableNCT06029218

Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy

Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy : Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy


Sponsor

Centre Antoine Lacassagne

Enrollment

106 participants

Start Date

Sep 13, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Thanks to the intrinsic qualities of the proton beam, proton therapy will reduce adverse effects of irradiation. The Proteus®One is the latest generation of proton therapy equipment, enabling the Centre Antoine Lacassagne to expand its range of treatments by carrying out new proton therapy treatments. It has an innovative compact isocentric rotating head (Gantry) that allows the radiation beam to be directed at different angles around the patient. In some cases, two beams are used to treat tumours, and by convention, both beams are delivered during the same session. However, it is necessary to position the patient before each beam, which is time-consuming because 2 beams have to be positioned very precisely each day. The aim of this study is therefore to assess the toxicity of proton therapy delivered by a single daily beam compared with proton therapy delivered by two daily beams, which is the conventional technique.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two radiation delivery schedules for patients receiving proton therapy — a precise form of radiation therapy — for certain rare bone and cartilage tumors (chordoma, chondrosarcoma) and bone sarcomas (Ewing's sarcoma, osteosarcoma) at the skull base or spine. The comparison is delivering treatment in 2 daily beams vs. 1 daily beam to see which approach is safer and more effective. **You may be eligible if...** - You are 18 or older with chordoma, chondrosarcoma, Ewing's sarcoma, or osteosarcoma that requires proton therapy using 2 beams - You have a recent MRI (within the last month) - You have health insurance coverage - Women of childbearing age must have a negative pregnancy test and use contraception during and 6 months after treatment **You may NOT be eligible if...** - You are deprived of legal rights or under guardianship - You are unable to follow up due to geographic, social, or psychological reasons - You are eligible for symptom-reduction surgery only Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONProteus ONE one daily beam

A single daily beam is used, doubling the dose delivered for this treatment incidence.

RADIATIONProteus ONE two daily beam

two daily beams are used, in accordance with the initial treatment plan and the patient's standard of care


Locations(1)

Centre Antoine lacassagne

Nice, France

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NCT06029218


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