RecruitingPhase 2NCT06068543
Reducing Frailty for Older Cancer Survivors Using Supplements II
A Phase 2 Randomized Controlled Trial of Epigallocatechin-3-Gallate (EGCG) on Frailty and Inflammation in Older Survivors of Cancer
Sponsor
University of Rochester
Enrollment
118 participants
Start Date
Oct 25, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
This study is a two-arm placebo controlled randomized clinical trial, to assess the effect of a 12-week EGCG intervention on physical frailty compared to placebo in pre-frail older cancer survivors.
Eligibility
Min Age: 65 Years
Inclusion Criteria5
- Be age 65 or over.
- Be diagnosed with stage I-III Cancer
- Have completed curative intent treatment ≤10 years prior to screening Patients on the following endocrine therapies are allowed to enroll (Anastrozole,Leuprolide acetate, and Bicalutamide)
- Have a Fried's Frailty Score (FFS) of ≥ 1
- Able to provide informed consent
Exclusion Criteria10
- Have chemotherapy or other systemic cancer treatment planned to occur during the study period.
- Have abnormal liver function tests (ALT, AST, and bilirubin) per most recent available lab test (within 3 months of screening)
- times institutional upper limit of normal for ALT and AST
- 5 times institutional upper limit of normal for bilirubin
- Have uncontrolled or unmanaged liver disease.
- Consume more than 6 cups of green tea per day.
- Have known allergies to caffeine.
- Be diagnosed with a major psychiatric illness requiring hospitalization within the last year.
- Be diagnosed with dementia.
- Cannot provide informed consent due to lack of decision-making capacity (as determined by the patient's oncologist).
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Interventions
DRUGEpigallocatechin-3-Gallate (EGCG)
800mg Epigallocatechin-3-Gallate (EGCG)
DRUGMicrocrystalline cellulose (MCC)
800mg microcrystalline cellulose (MCC)
DIETARY_SUPPLEMENTAscorbic Acid (Vitamin C)
250mg Ascorbic Acid (Vitamin C) taken one time daily for 12 weeks
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06068543
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