RecruitingNot ApplicableNCT06110143

Oral Health and Adverse Pregnancy Complications

The Prevention of Adverse Pregnancy Outcomes by Periodontal Treatment (PROBE) Intervention Study

Sponsor

University Hospital Bispebjerg and Frederiksberg

Enrollment

600 participants

Start Date

Nov 13, 2021

Study Type

INTERVENTIONAL

Conditions

Inflammation Pregnancy Complications Preeclampsia Periodontal Diseases Gestational Diabetes Pregnancy Preterm

Summary

Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected. Periodontitis is accompanied by a low-grade systemic inflammation and can be harmful to the general health of the woman, contribute to pre-term birth and adversely influence the future health and metabolism of the offspring. Despite this, studies indicate that 40% of Danish women in childbearing age do not visit a dentist regularly. The PROBE controlled intervention study will investigate the beneficial effect of treatment of periodontal disease during pregnancy on fetal growth, preterm delivery and birth weight.

Eligibility

Sex: FEMALEMin Age: 16 YearsMax Age: 48 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether treating gum disease (periodontitis) during pregnancy reduces the risk of complications like preeclampsia or preterm birth. Pregnant women with gum disease are enrolled and their pregnancy outcomes are tracked. **You may be eligible if...** - You are pregnant and planning to give birth at Holbaek or Nykoebing Falster hospital in Denmark - You have been diagnosed with periodontitis (stage I, II, or III) by the study dentist **You may NOT be eligible if...** - You do not have periodontitis - You have fewer than 20 healthy teeth - You are already receiving treatment for gum disease - You have very severe (stage IV) periodontitis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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