Mechanical Ventilation on Hippocampus
Impact of Mechanical Ventilation on Hippocampal Oscillation and Respiratory-hippocampus Coupling
Beijing Sanbo Brain Hospital
20 participants
May 8, 2024
OBSERVATIONAL
Conditions
Summary
Ventilator-associated brain injury (VABI) frequently occurs in ICU patients. Although animal studies indicate the hippocampus as a key target of VABI, its relevance in human patients remains uncertain. In this study, the investigators aim to monitor hippocampal EEG activity during the weaning process of patients off mechanical ventilation, and also exploring the coupling between breathing patterns and hippocampal activity.
Eligibility
Inclusion Criteria4
- Age: ≥ 18 years
- ASA: I - II
- w/ electrode inside hippocampus (≥ 1 contacts)
- Singed consent form
Exclusion Criteria8
- Seizure occurrence ≤ 36 hours before op.
- Structural brain damage
- History of using: opioids, enzyme-inducing medications, sleep aids, or excessive alcohol consumption
- History of mechanical ventilation (>24h)
- Cognitive impairment
- Operation within 6 months
- Participate in other clinical trials in the last four weeks
- Pregnant or breastfeeding
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
After replacing the electrode, we'll monitor the EEG activity of the hippocampus and other cortex regions while weaning off mechanical ventilation.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06480162