Ultralong-segment Barrett's Esophagus: Towards a Capsule-sponge Surveillance Strategy

This study is developing a new, less invasive way to monitor very long stretches of Barrett's esophagus — a condition where the lining of the esophagus (food pipe) changes due to chronic acid reflux and can sometimes lead to cancer. The study tests whether a swallowed capsule-sponge device can be used for surveillance instead of a traditional endoscopy. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with ultralong-segment Barrett's esophagus (a very extensive area of abnormal lining) - You are medically fit to undergo a standard endoscopy - You are able to give informed consent **You may NOT be eligible if...** - You have been diagnosed with throat, esophageal, or stomach cancer (stage T2 or above) - You have difficulty swallowing (dysphagia) - You have esophageal varices (enlarged veins in the esophagus) or a stricture that needs dilation - You had a stroke in the last 6 months affecting your ability to swallow - You have previously had certain esophageal treatments (photodynamic therapy, radiofrequency ablation, or argon plasma coagulation) for precancerous Barrett's Talk to your doctor to see if this trial is right for you.