RecruitingNot ApplicableNCT06733714

Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults

Sponsor

Universidade Federal do Rio de Janeiro

Enrollment

40 participants

Start Date

Dec 2, 2024

Study Type

INTERVENTIONAL

Conditions

Dementia Cognitive Dysfunction Cognitive Decline Alzheimer Disease Dementia, Vascular Mild Cognitive Impairment Lewy Body Disease Frontotemporal Degeneration Beta-Amyloid GFAP Tau Protein

Summary

BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy. Digital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints. METHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.

Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining gentle brain stimulation (transcranial alternating current stimulation, or tACS) with digital cognitive training exercises can improve memory and thinking in healthy older adults who notice their cognition is declining. **You may be eligible if...** - You are over 50 years old - You are generally healthy but have noticed some decline in your memory or thinking - You do not have a formal diagnosis of dementia **You may NOT be eligible if...** - Your estimated IQ is below 80 - You have a serious psychiatric or neurological disorder - You have uncorrected vision or hearing problems - You have had a stroke or unexplained fainting/seizure in the past year - You use blood-thinning medications (anticoagulants) - You have a metal implant in your skull or a cardiac pacemaker - There is any other reason you cannot safely undergo tACS brain stimulation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial Alternating Current Stimulation

An alternate eletric current of 1.6mA in theta frequency is applied in the scalp, using two eletrodes (5x5cm). The eletrodes are located aiming for the left dorsolateral prefrontal Cortex area.

DEVICEDigital Cognitive Training

Using a tablet, the participant will do exercises that were designed to stimulate cognitive domains, especially attention and memory. In this case, we use the BrainHQ platform.