Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.

This study looks at how moderate wine consumption affects small particles released into the bloodstream after a meal (called extracellular vesicles), and whether this tells us anything about healthy aging in middle-aged adults. **You may be eligible if...** - You are a healthy man or woman between 35 and 65 years old - Your BMI is between 18.5 and 29.9 (normal to overweight range) - You are a non-smoker or have quit smoking for at least 12 months - You drink alcohol in moderation (no more than 2 units per day for men; 1 unit per day for women) - Your fasting blood sugar and cholesterol levels are normal - You are willing to avoid alcohol, polyphenol-rich foods, and intense exercise for 48 hours before each study visit **You may NOT be eligible if...** - You have a history of heart, liver, kidney, thyroid, gut, or metabolic disease (including diabetes, high cholesterol, or hypertension) - You take statins, steroids, or anti-inflammatory drugs regularly - You are pregnant or breastfeeding - You donated blood in the past 3 months - You have a known allergy to wine or its components (such as sulfites) - You have a history of alcohol misuse - Your weight changed by more than 5% in the past 3 months Talk to your doctor to see if this trial is right for you.