RecruitingNot ApplicableNCT07417280

LIFUS For Neurological Disorders

Clinical Effects of Low-Intensity Focused Ultrasound Neuromodulation in Patients With Neurological and Psychiatric Disorders


Sponsor

University Health Network, Toronto

Enrollment

50 participants

Start Date

Dec 2, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation. Studies in healthy subjects have shown that application of LIFUS to the motor region of the brain can mildly decrease neuron excitability in healthy controls. The purpose of the present study is to evaluate the effects of LIFUS on brain tissue excitability in patients with movement disorders in order to elucidate the therapeutic potential of LIFUS.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study uses a non-invasive brain stimulation technique called low-intensity focused ultrasound (LIFUS) to treat neurological and psychiatric conditions. LIFUS delivers gentle sound waves through the skull to stimulate specific areas of the brain without surgery. **You may be eligible if...** - You are 18 to 85 years old - You have been diagnosed with a neurological disorder (such as epilepsy, brain tumor, or movement disorder) or psychiatric disorder (such as substance use disorder) - You are already undergoing medical or surgical treatment for your condition **You may NOT be eligible if...** - You fall outside the age range - You do not have a qualifying neurological or psychiatric condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICELIFUS

Low-intensity focused ultrasound neuromodulation delivered to targeted cortical and/or subcortical brain regions to transiently modulate neural activity. LIFUS may be applied alone or in combination with concurrent neurophysiological assessments (e.g., TMS-evoked motor evoked potentials, EEG recordings, or DBS local field potential sensing) depending on the study component.

DEVICESham LIFUS

Sham low-intensity focused ultrasound stimulation designed to mimic the sensory and procedural aspects of active LIFUS without delivering therapeutic ultrasound energy. The sham condition serves as a control to maintain blinding of participants and investigators.


Locations(1)

Toronto Western Hospital, 399 Bathurst St

Toronto, Ontario, Canada

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NCT07417280


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