Phase 1 Alcohol Clinical Trials
47 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 47 trials
Recruiting
Phase 1
Environment and Alcohol: A Pilot Study
Alcohol Use Disorder
National Institute on Drug Abuse (NIDA)44 enrolled1 locationNCT06860607
Recruiting
Phase 1
Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS)
Weight LossAlcohol Use DisorderBariatric Surgery Patients
Yale University10 enrolled1 locationNCT07223983
Recruiting
Phase 1Phase 2
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
CirrhosisAlcohol Use DisorderLiver Disease; Alcohol-Related
Virginia Commonwealth University80 enrolled2 locationsNCT05548452
Recruiting
Phase 1
Spironolactone in Alcohol Use Disorder (SAUD)
Alcohol Use Disorder
National Institute on Drug Abuse (NIDA)20 enrolled1 locationNCT05807139
Recruiting
Phase 1
The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)
Alcohol Use Disorder (AUD)Alcohol-Related DisordersAlcohol Use
Yale University63 enrolled1 locationNCT06070649
Recruiting
Phase 1
Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers
Alcohol Associated Liver DiseaseHeavy Drinking Behavior
National Institute on Alcohol Abuse and Alcoholism (NIAAA)100 enrolled1 locationNCT04781322
Recruiting
Phase 1
A Safety, Tolerability, Pharmacokinetics/Pharmacodynamics Study of HEC169584 Capsules in Healthy Subjects
Non Alcoholic Steatohepatitis
Sunshine Lake Pharma Co., Ltd.96 enrolled1 locationNCT07099118
Recruiting
Phase 1Phase 2
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Healthy VolunteersAlcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)180 enrolled1 locationNCT06484075
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder
Alcohol Use Disorder
National Institute of Mental Health (NIMH)30 enrolled1 locationNCT06795581
Recruiting
Phase 1
Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)
Alcohol Use Disorder
National Institute of Mental Health (NIMH)30 enrolled1 locationNCT07027839
Recruiting
Phase 1
Nicotinic Receptor Genetic Variation and Alcohol Reward
Alcohol Drinking
National Institute on Alcohol Abuse and Alcoholism (NIAAA)128 enrolled1 locationNCT03294460
Recruiting
Phase 1
A Study of Efimosfermin Alfa in Adults With Hepatic Impairment
Non-Alcoholic Fatty Liver Disease
GlaxoSmithKline32 enrolled3 locationsNCT07358546
Recruiting
Phase 1
Effect of Insulin Lowering on Lipogenesis
ObesityInsulin ResistanceNon-Alcoholic Fatty Liver Disease+2 more
Columbia University25 enrolled1 locationNCT07403604
Recruiting
Phase 1
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Insulin ResistanceNon-Alcoholic Fatty Liver DiseaseOverweight and Obesity+1 more
Columbia University32 enrolled1 locationNCT06354088
Recruiting
Phase 1
Study of NTX-2001 on Alcohol Consumption in Alcohol Use Disorder
Alcohol Use Disorder
Newleos Therapeutics, Inc.50 enrolled1 locationNCT07520292
Recruiting
Phase 1Phase 2
A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects
Alcohol Use Disorder
Clearmind Medicine Inc.84 enrolled4 locationsNCT05913752
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Efimosfermin Alfa Administered as a Single Dose to Healthy Participants of Chinese, Japanese, and White/European Ancestry
Non-Alcoholic Fatty Liver Disease
GlaxoSmithKline30 enrolled1 locationNCT07335198
Recruiting
Phase 1
Evaluation of Miricorilant on Liver Fat in Patients With MASLD
Nonalcoholic Steatohepatitis (NASH)Metabolic dysfunction-associated steatohepatitis (MASH)Non-alcoholic Fatty Liver Disease NAFLD+1 more
Corcept Therapeutics8 enrolled1 locationNCT06947304
Recruiting
Phase 1
Diclofenac Dose Response Study
Alcohol Use Disorder (AUD)Alcohol-Related Disorders
University of Maryland, Baltimore24 enrolled1 locationNCT06636227
Recruiting
Phase 1
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
Cannabis UseAlcohol DrinkingHIV+1 more
Yale University100 enrolled1 locationNCT06513819