Phase 1 Alcohol Clinical Trials
50 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 50 trials
Recruiting
Phase 1
Environment and Alcohol: A Pilot Study
Alcohol Use Disorder
National Institute on Drug Abuse (NIDA)44 enrolled1 locationNCT06860607
Recruiting
Phase 1
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Alcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)176 enrolled1 locationNCT07559500
Recruiting
Phase 1
Spironolactone in Alcohol Use Disorder (SAUD)
Alcohol Use Disorder
National Institute on Drug Abuse (NIDA)20 enrolled1 locationNCT05807139
Recruiting
Phase 1Phase 2
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
CirrhosisAlcohol Use DisorderLiver Disease; Alcohol-Related
Virginia Commonwealth University80 enrolled2 locationsNCT05548452
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder
Alcohol Use Disorder
National Institute of Mental Health (NIMH)30 enrolled1 locationNCT06795581
Recruiting
Phase 1
Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)
Alcohol Use Disorder
National Institute of Mental Health (NIMH)30 enrolled1 locationNCT07027839
Recruiting
Phase 1
Effect of Insulin Lowering on Lipogenesis
ObesityInsulin ResistanceNon-Alcoholic Fatty Liver Disease+2 more
Columbia University25 enrolled1 locationNCT07403604
Recruiting
Phase 1
Nicotinic Receptor Genetic Variation and Alcohol Reward
Alcohol Drinking
National Institute on Alcohol Abuse and Alcoholism (NIAAA)128 enrolled1 locationNCT03294460
Recruiting
Phase 1Phase 2
Ketamine for Combined Depression and Alcohol Use Disorder
DepressionAlcohol Use Disorder
University Hospital of North Norway34 enrolled1 locationNCT06090422
Recruiting
Phase 1Phase 2
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Healthy VolunteersAlcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)180 enrolled1 locationNCT06484075
Recruiting
Phase 1
A Study of Efimosfermin Alfa in Adults With Hepatic Impairment
Non-Alcoholic Fatty Liver Disease
GlaxoSmithKline32 enrolled3 locationsNCT07358546
Recruiting
Phase 1
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
Heavy DrinkerAlcohol ConsumptionAlcohol Use Disorder (AUD)
Yale University63 enrolled2 locationsNCT06136195
Recruiting
Phase 1
Evaluating the Pharmacokinetics and Safety of Miricorilant
Nonalcoholic Steatohepatitis (NASH)Non-alcoholic Fatty Liver Disease NAFLDMetabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis+1 more
Corcept Therapeutics15 enrolled1 locationNCT07553663
Recruiting
Phase 1
Sex Differences in the Response to Abstinence From Alcohol.
Alcohol Use Disorder
Indiana University160 enrolled1 locationNCT03827460
Recruiting
Phase 1
Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS)
Weight LossAlcohol Use DisorderBariatric Surgery Patients
Yale University10 enrolled1 locationNCT07223983
Recruiting
Phase 1
The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)
Alcohol Use Disorder (AUD)Alcohol-Related DisordersAlcohol Use
Yale University63 enrolled1 locationNCT06070649
Recruiting
Phase 1
Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers
Alcohol Associated Liver DiseaseHeavy Drinking Behavior
National Institute on Alcohol Abuse and Alcoholism (NIAAA)100 enrolled1 locationNCT04781322
Recruiting
Phase 1
A Safety, Tolerability, Pharmacokinetics/Pharmacodynamics Study of HEC169584 Capsules in Healthy Subjects
Non Alcoholic Steatohepatitis
Sunshine Lake Pharma Co., Ltd.96 enrolled1 locationNCT07099118
Recruiting
Phase 1
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Insulin ResistanceNon-Alcoholic Fatty Liver DiseaseOverweight and Obesity+1 more
Columbia University32 enrolled1 locationNCT06354088
Recruiting
Phase 1
Study of NTX-2001 on Alcohol Consumption in Alcohol Use Disorder
Alcohol Use Disorder
Newleos Therapeutics, Inc.50 enrolled1 locationNCT07520292