Phase 1 Alzheimer s Disease Clinical Trials
12 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–12 of 12 trials
Recruiting
Phase 1
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
DementiaALSMild Cognitive Impairment+2 more
National Institute of Mental Health (NIMH)184 enrolled1 locationNCT04396873
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1Phase 2
A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
Alzheimer s Disease
AbbVie210 enrolled10 locationsNCT07599670
Recruiting
Phase 1
A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease
Alzheimer s Disease
Alnylam Pharmaceuticals50 enrolled13 locationsNCT07214727
Recruiting
Phase 1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Participants With Early Symptomatic Alzheimer's Disease (eAD)
Alzheimer s Disease
Hoffmann-La Roche50 enrolled8 locationsNCT07234942
Recruiting
Phase 1Phase 2
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
Alzheimer s DiseaseBeta-AmyloidProdromal Alzheimer's Disease+2 more
AC Immune SA304 enrolled26 locationsNCT05462106
Recruiting
Phase 1
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentAlzheimer s Disease
University of California, San Diego60 enrolled1 locationNCT06548191
Recruiting
Phase 1
Alzheimer's Disease and Faecal Microbiota Transplantation -a Pilot Study
Alzheimer s DiseaseFaecal Microbiota Transplantation (FMT)
University Hospital of North Norway10 enrolled1 locationNCT07332260
Recruiting
Phase 1Phase 2
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
Multiple SclerosisAlzheimer s Disease
Brigham and Women's Hospital250 enrolled1 locationNCT02649985
Recruiting
Phase 1
Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease
Healthy VolunteersDown SyndromeAlzheimer s Disease
Perha Pharmaceuticals164 enrolled1 locationNCT06206824
Recruiting
Phase 1
A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment
Mild Cognitive ImpairmentAlzheimer s Disease
Mark Tuszynski12 enrolled2 locationsNCT05040217
Recruiting
Phase 1
Safety and Target Engagement of Centella Asiatica in Cognitive Impairment
Mild Cognitive ImpairmentAlzheimer s Disease
Oregon Health and Science University48 enrolled1 locationNCT05591027