Early Phase 1 ART Clinical Trials
34 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 34 trials
Recruiting
Early Phase 1
Oral Carnitine in Heart Failure Patients
Heart FailureCarnitine Deficiency
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's20 enrolled1 locationNCT07201714
Recruiting
Early Phase 1
UCAR T-cell Therapy Targeting CD19/BCMA in Relapsed/Refractory Autoimmune Hemolytic Anemia
AIHA - Warm Autoimmune Hemolytic AnemiaUCART
The Second Hospital of Anhui Medical University15 enrolled1 locationNCT07530380
Recruiting
Early Phase 1
Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients
Arterial HypertensionMicrovascular FunctionResistant Hypertension+1 more
National Institute of Cardiology, Laranjeiras, Brazil50 enrolled1 locationNCT06169241
Recruiting
Early Phase 1
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
Heart Failure With Preserved Ejection FractionType2 Diabetes
The University of Texas Health Science Center at San Antonio30 enrolled1 locationNCT05057806
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases
Systemic Lupus Erythematosus (SLE)Rheumatic DiseasesPediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)+1 more
The Children's Hospital of Zhejiang University School of Medicine36 enrolled1 locationNCT07490041
Recruiting
Early Phase 1
Mechanistic Clinical Trial of Colchicine in Patients With Peripheral Artery Disease
Peripheral Artery Disease
University of Pennsylvania24 enrolled1 locationNCT06212271
Recruiting
Early Phase 1
A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
DepressionKnee Osteoarthritis
University of California, Los Angeles30 enrolled1 locationNCT06906939
Recruiting
Early Phase 1
Human Amniotic-Derived Mesenchymal Stem Cell Therapy for Calciphylaxis
EfficacyTreatmentChronic Kidney Diseases+3 more
The First Affiliated Hospital with Nanjing Medical University9 enrolled1 locationNCT04592640
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
Rheumatoid ArthritisSystemic Lupus ErythematosusAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis+3 more
Changhai Hospital60 enrolled1 locationNCT07246096
Recruiting
Early Phase 1
Vascular Effects of High-Salt After Preeclampsia
PreeclampsiaPreeclampsia Postpartum
Anna Stanhewicz, PhD40 enrolled1 locationNCT06749418
Recruiting
Early Phase 1
Ketones, SGLT2, HFrEF
Heart Failure With Reduced Ejection FractionType2diabetes
The University of Texas Health Science Center at San Antonio71 enrolled1 locationNCT06229678
Recruiting
Early Phase 1
PET Image in PAH Patients
Pulmonary Arterial Hypertension
Stephen Y. Chan71 enrolled1 locationNCT05452889
Recruiting
Early Phase 1
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
Type 2 DiabetesHeart Failure, Reduced Ejection Fraction
The University of Texas Health Science Center at San Antonio10 enrolled1 locationNCT06108076
Recruiting
Early Phase 1
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
Healthy ParticipantsProgressive Supranuclear Palsy (PSP)
Invicro24 enrolled1 locationNCT07348276
Recruiting
Early Phase 1
Clinical Study of (A-319) in the Treatment of Active Rheumatoid Arthritis
Rheumatoid Arthritis (RA)
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology12 enrolled1 locationNCT07347860
Recruiting
Early Phase 1
Single and Multiple Ascending Doses of NTX-253 in Healthy Participants and Participants With Stable Schizophrenia
Healthy ParticipantsSchizophrenia Diagnosis
Neurosterix73 enrolled1 locationNCT07344948
Recruiting
Early Phase 1
Diffusion MRI in Heart Failure
Heart FailureMyocardial InfarctionLeft Ventricular Hypertrophy
Massachusetts General Hospital160 enrolled1 locationNCT02973633
Not Yet Recruiting
Early Phase 1
A first-in-human trial to assess safety of adenosine-lidocaine-magnesium (ALM) therapy for elective knee surgery
Osteoarthritis
James Cook University12 enrolled1 locationACTRN12625001418460
Recruiting
Early Phase 1
Researching Economical Adjuvants to Cancer Therapy
Healthy Participants
Florida State University60 enrolled1 locationNCT07305259
Recruiting
Early Phase 1
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Peripheral Arterial DiseasePeripheral Vascular DiseasesPeripheral Artery Disease
University of Nebraska20 enrolled1 locationNCT06319339