Connective Tissue Disease Clinical Trials

43 recruitingLast updated: June 18, 2026

There are 43 actively recruiting connective tissue disease clinical trials across 29 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1. Top locations include New York, New York, United States, Durham, North Carolina, United States, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Connective Tissue Disease Trials at a Glance

43 actively recruiting trials for connective tissue disease are listed on ClinicalTrialsFinder across 6 cities in 29 countries. The largest study group is Not Applicable with 11 trials, with the heaviest enrollment activity in New York, Durham, and Beijing. Lead sponsors running connective tissue disease studies include Institute of Hematology & Blood Diseases Hospital, China, Hospital de Granollers, and University of Bonn.

Browse connective tissue disease trials by phase

Treatments under study

About Connective Tissue Disease Clinical Trials

Looking for clinical trials for Connective Tissue Disease? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Connective Tissue Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Connective Tissue Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting

Right Ventricle Lipid in Pulmonary Arterial Hypertension (PAH)

Idiopathic Pulmonary Arterial HypertensionHeritable Pulmonary Arterial HypertensionPulmonary Arterial Hypertension Associated With Connective Tissue Disease
Vanderbilt University Medical Center75 enrolled1 locationNCT05462574
Recruiting
Phase 1Phase 2

ADSCs Therapy in Patients With CTD-ILD

Interstitial Lung DiseaseConnective Tissue Diseases
China Medical University Hospital16 enrolled1 locationNCT06574581
Recruiting
Phase 2

Intralesional Injection of STS in Treatment of Calcinosis

DermatomyositisSystemic Sclerosis (SSc)Mixed Connective Tissue Disease (MCTD)+1 more
Robyn T. Domsic, MD, MPH20 enrolled1 locationNCT06672822
Recruiting
Not Applicable

Early Recognition of Progressive Lung Fibrosis in Systemic Rheumatic Diseases

Interstitial Lung DiseaseConnective Tissue Diseases
Fondazione Policlinico Universitario Agostino Gemelli IRCCS200 enrolled1 locationNCT07541638
Recruiting
Not Applicable

Optimizing the Follow-Up Journey in Interstitial Lung Disease: The OPTIMIZE-ILD-2 Trial

Progressive Pulmonary FibrosisFibrotic interstitial lung diseaseInterstitial Lung Disease (ILD)+2 more
Hospital de Granollers152 enrolled1 locationNCT07486206
Recruiting
Not Applicable

Optimizing the Diagnostic Journey in Interstitial Lung Disease: The OPTIMIZE-ILD-1 Trial

Fibrotic interstitial lung diseaseInterstitial Lung Disease (ILD)Idiopathic Pulmonary Fibrosis (IPF)+2 more
Hospital de Granollers92 enrolled1 locationNCT07482917
Recruiting
Phase 2

A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

Progressive Pulmonary FibrosisInterstitial Lung DiseasePulmonary Fibrosis+7 more
Avalyn Pharma Inc.375 enrolled152 locationsNCT06329401
Recruiting
Early Phase 1

Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases

Systemic Lupus Erythematosus (SLE)Rheumatic DiseasesPediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)+1 more
The Children's Hospital of Zhejiang University School of Medicine36 enrolled1 locationNCT07490041
Recruiting
Not Applicable

Impact of Capillaroscopy in the Investigation of Diffuse Interstitial Pneumonias

Interstitial Lung DiseaseConnective Tissue Diseases
University Hospital, Bordeaux48 enrolled1 locationNCT07283081
Recruiting
Not Applicable

Impact of Capillaroscopy on the Management of Undifferentiated Connective Tissue Disease

Undifferentiated Connective Tissue Diseases
CHU de Quebec-Universite Laval40 enrolled1 locationNCT06399822
Recruiting

Heart Institute Biobank & Registry for Adult Congenital Heart Disease and Related Disorders

Pulmonary HypertensionConnective Tissue DiseaseAdult Congenital Heart Disease+1 more
Children's Hospital Medical Center, Cincinnati5,000 enrolled1 locationNCT07477197
Recruiting
Phase 2

A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease

Non-small Cell Lung CancerNSCLCNSCLC Stage II+5 more
Memorial Sloan Kettering Cancer Center25 enrolled7 locationsNCT07323732
Recruiting
Phase 2

129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial HypertensionConnective Tissue DiseasesIdiopathic Pulmonary Arterial Hypertension+1 more
Bastiaan Driehuys20 enrolled1 locationNCT06104228
Recruiting

Rheumatology Patient Registry and Biorepository

Rheumatoid ArthritisLyme DiseaseSarcoidosis+17 more
Yale University5,000 enrolled1 locationNCT04402086
Recruiting

Undifferentiated Connective Tissue Disease Registry

Undifferentiated Connective Tissue Disease
Hospital for Special Surgery, New York100 enrolled1 locationNCT02234388
Recruiting
Not Applicable

Ganglion Resection Effectiveness Trial

Connective Tissue DiseaseWrist GanglionGanglion+2 more
Tampere University Hospital220 enrolled4 locationsNCT07162415
Recruiting
Phase 1

CAR T-cell Therapy Targeting CD19 and BCMA(QT-019C) in Patients With Relapse/Refractory Autoimmune Diseases

ANCA Associated Vasculitis (AAV)SLE - Systemic Lupus ErythematosusSSc-Systemic Sclerosis+3 more
Institute of Hematology & Blood Diseases Hospital, China12 enrolled1 locationNCT07315087
Recruiting
Not Applicable

Creating Health Course Study for People With Rheumatological Conditions

Rheumatoid ArthritisPsoriatic ArthritisSystemic Lupus Erythematosus+2 more
Terry L. Wahls200 enrolled1 locationNCT07180537
Recruiting
Phase 4

A Study to Test Tetrandrine Tablets for Connective Tissue Disease-Related Lung Disease

Interstitial Lung Disease (ILD)Connective Tissue Disease-associated Interstitial Lung Disease
Peking University Third Hospital100 enrolled1 locationNCT07319598
Recruiting
Phase 3

A Study to Learn About the Safety and Efficacy of the Drug Oleogel-S10 in Japanese Patients With Epidermolysis Bullosa

Skin DiseasesEpidermolysis BullosaConnective Tissue Disease+7 more
Chiesi Farmaceutici S.p.A.6 enrolled6 locationsNCT06917690