Phase 2 Cystic Fibrosis Clinical Trials
23 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 23 trials
Recruiting
Phase 2Phase 3
Maralixibat in Patients With Cystic Fibrosis and Constipation
Cystic FibrosisConstipation Chronic Idiopathic
Children's Hospital Los Angeles20 enrolled1 locationNCT06413368
Recruiting
Phase 2
Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function
Cystic FibrosisCystic Fibrosis-related Diabetes
University of Kansas Medical Center30 enrolled1 locationNCT04530383
Recruiting
Phase 1Phase 2
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease
Chronic Obstructive Pulmonary DiseaseNon-cystic Fibrosis Bronchiectasis
Genentech, Inc.128 enrolled7 locationsNCT06603246
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated39 enrolled43 locationsNCT05668741
Recruiting
Phase 2
4D-710 in Adult Patients With Cystic Fibrosis
Cystic Fibrosis Lung
4D Molecular Therapeutics30 enrolled20 locationsNCT05248230
Recruiting
Phase 2
Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of SION-719 When Added to Trikafta
Cystic Fibrosis (CF)
Sionna Therapeutics Inc.16 enrolled13 locationsNCT07108153
Recruiting
Phase 2
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
AsthmaCystic Fibrosis
The Hospital for Sick Children30 enrolled1 locationNCT02740868
Recruiting
Phase 2
A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy Participants and in Participants With CF
Cystic Fibrosis
ReCode Therapeutics192 enrolled23 locationsNCT06237335
Recruiting
Phase 1Phase 2
A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection
Cystic Fibrosis LungRespiratory Infections, Recurrent, Chronic
Respirion Pharmaceuticals Pty Ltd72 enrolled22 locationsNCT06016088
Recruiting
Phase 2
Dose Range Finding, Efficacy, and Safety Study of Nebulized CSL787 in Adults With Non-cystic Fibrosis Bronchiectasis (NCFB)
Non-cystic Fibrosis Bronchiectasis
CSL Behring450 enrolled13 locationsNCT07048262
Recruiting
Phase 2
A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
Non-cystic Fibrosis Bronchiectasis
Verona Pharma plc180 enrolled50 locationsNCT06559150
Recruiting
Phase 2
Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis
Cystic FibrosisCFTR Gene Mutation
Arcturus Therapeutics, Inc.12 enrolled11 locationsNCT06747858
Recruiting
Phase 2
Study With Phage for CF Subjects With Pseudomonas Lung Infection
Cystic Fibrosis (CF)Chronic Pseudomonas Aeruginosa Infection
BiomX Ltd63 enrolled14 locationsNCT06998043
Recruiting
Phase 2
Targeting Inflammation With Losartan to Improve Response to Modulator Therapy in Cystic Fibrosis.
Cystic Fibrosis
University of Kansas Medical Center42 enrolled1 locationNCT06364176
Recruiting
Phase 2
GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance
Cystic FibrosisDiabetesPancreatic Insufficiency+1 more
University of Pennsylvania30 enrolled2 locationsNCT04731272
Recruiting
Phase 2
A Study to Evaluate Safety and Efficacy of Subcutaneous Administration of Anakinra in Patients With CF
Cystic Fibrosis, 10011762
Heidelberg University52 enrolled3 locationsNCT03925194
Recruiting
Phase 2
Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients with Cystic Fibrosis
Cystic Fibrosis
SpliSense Ltd.24 enrolled2 locationsNCT06429176
Recruiting
Phase 1Phase 2
A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)
Cystic Fibrosis
Spirovant Sciences, Inc.15 enrolled4 locationsNCT06526923
Completed
Phase 2
Assessment of Citramel in Patients with Cystic Fibrosis
Cystic Fibrosis
Breathe Easy Ltd24 enrolled4 locationsACTRN12615000654550
Recruiting
Phase 2
A study examining the utility of inhaled mannitol as an additional therapy during an admission to hospital for an acute pulmonary exacerbation in children with cystic fibrosis
Cystic Fibrosis
The Children's Hospital at Westmead30 enrolled1 locationACTRN12612001167853