Phase 1 Cystic Fibrosis Clinical Trials
19 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–19 of 19 trials
Recruiting
Phase 1
Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated255 enrolled12 locationsNCT06154447
Recruiting
Phase 1Phase 2
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease
Chronic Obstructive Pulmonary DiseaseNon-cystic Fibrosis Bronchiectasis
Genentech, Inc.128 enrolled7 locationsNCT06603246
Recruiting
Phase 1
Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis
Cystic Fibrosis-related DiabetesPancreatic Insufficiency
University of Pennsylvania15 enrolled2 locationsNCT06995651
Recruiting
Phase 1
Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated128 enrolled1 locationNCT07437105
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated39 enrolled43 locationsNCT05668741
Recruiting
Phase 1
A Clinical Study of RSS0343 in Healthy Subjects
Non-cystic Fibrosis Bronchiectasis
Reistone Biopharma Company Limited48 enrolled1 locationNCT07289464
Recruiting
Phase 1Phase 2
A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection
Cystic Fibrosis LungRespiratory Infections, Recurrent, Chronic
Respirion Pharmaceuticals Pty Ltd72 enrolled22 locationsNCT06016088
Recruiting
Phase 1
Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated128 enrolled1 locationNCT07283770
Recruiting
Phase 1
Safety, Tolerability, and Pharmacokinetics of Multiple Dose Combinations of SION-451 and Complementary Modulators SION-2222 and SION-109 in Healthy Participants.
Cystic Fibrosis (CF)
Sionna Therapeutics Inc.144 enrolled2 locationsNCT07035990
Recruiting
Phase 1
A Study Assessing KB407 for the Treatment of Cystic Fibrosis
Cystic Fibrosis
Krystal Biotech, Inc.12 enrolled5 locationsNCT05504837
Recruiting
Phase 1
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
AsthmaCOPDCystic Fibrosis+4 more
Mario Castro, MD, MPH260 enrolled1 locationNCT04624490
Recruiting
Phase 1
Study to Assess Amphotericin B Cystetic for Inhalation (ABCI) Doses in Healthy Volunteers & People with Cystic Fibrosis
Cystic Fibrosis
Cystetic Medicines, Inc.108 enrolled5 locationsNCT05802264
Recruiting
Phase 1Phase 2
A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)
Cystic Fibrosis
Spirovant Sciences, Inc.15 enrolled4 locationsNCT06526923
Recruiting
Phase 1
A Phase 1 randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of single ascending doses and multiple ascending doses of SION-451 in healthy participants
Cystic Fibrosis
Sionna Therapeutics, Inc96 enrolled1 locationACTRN12624000849594
Not Yet Recruiting
Phase 1
A Phase 1 randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability. and pharmacokinetics of single ascending doses and multiple ascending doses of SION-451 in healthy participants - Part C
Cystic Fibrosis
Sionna Therapeutics, Inc24 enrolled1 locationACTRN12624000848505
Completed
Phase 1
A Phase 1 study to evaluate the safety and pharmacokinetics of single and multiple doses of SION-719 in healthy participants
Cystic Fibrosis
Sionna Therapeutics, Inc81 enrolled1 locationACTRN12624000739516
Recruiting
Phase 1
Orkambi in Patients with Cystic Fibrosis and Severe Liver Disease
Cystic FibrosisCystic Fibrosis Related Liver Disease
Dr Adeline Lim30 enrolled1 locationACTRN12619001347156
Completed
Phase 1
Single Ascending Dose and Multiple Ascending Dose Phase I study of PXS-4728A Administered Orally in Healthy Adult Males.
Chronic Obstructive Pulmonary DiseaseCystic Fibrosis
Pharmaxis Ltd.72 enrolled1 locationACTRN12614001326684
Completed
Phase 1
A single dose, 3-way cross-over study comparing the safety, tolerability and pharmacokinetics of two inhaled Liposomal Ciprofloxacin Hydrochloride (HCl) for Inhalation formulations in two different nebulizers in healthy adults, with single dose assessment in subjects with non-Cystic Fibrosis (CF) bronchiectasis.
Non-Cystic Fibrosis (CF) bronchiectasis
Aradigm Corporation15 enrolled1 locationACTRN12609000544279