Early Phase 1 Diseases Clinical Trials
38 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 38 trials
Recruiting
Early Phase 1
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Peripheral arterial occlusive diseasePeripheral Arterial DiseasePeripheral Vascular Diseases+1 more
University of Nebraska20 enrolled1 locationNCT06319339
Recruiting
Early Phase 1
A Clinical Study to Evaluate the Safety and Efficacy of GT801 Injection in the Treatment of Moderate to Severe Refractory Autoimmune Diseases
Moderate to Severe Refractory Autoimmune Diseases
Vivacta Biotechnology (Shanghai) Co., Ltd.22 enrolled1 locationNCT07614191
Recruiting
Early Phase 1
CD19/BCMA UCAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07586267
Recruiting
Early Phase 1
Repurposing Dupilumab for Management of Pruritic Genetic Inflammatory Skin Disorders
Skin Diseases
Northwestern University30 enrolled1 locationNCT05649098
Recruiting
Early Phase 1
Concomitant Renal and Urinary Bladder Allograft Transplantation
Chronic Kidney DiseasesBladder DysfunctionNeurogenic Bladder+6 more
Mayo Clinic30 enrolled2 locationsNCT04626167
Recruiting
Early Phase 1
Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP
Sexually Transmitted Diseases, Bacterial
University of California, San Francisco48 enrolled1 locationNCT06414408
Recruiting
Early Phase 1
Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07507201
Recruiting
Early Phase 1
A Study of mRNA Encoding CD19/CD3 T Cell Engager (ABO2203) in Patients With Refractory Autoimmune Diseases
Autoimmune Diseases
Ruijin Hospital66 enrolled3 locationsNCT06747156
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA CAR-NK Cell Injection for the Treatment of Refractory Pediatric Rheumatic Diseases
Systemic Lupus Erythematosus (SLE)Rheumatic DiseasesPediatric Rheumatological Condition (i.e., Arthritis, SLE, Kawasaki's Disaese)+1 more
The Children's Hospital of Zhejiang University School of Medicine36 enrolled1 locationNCT07490041
Recruiting
Early Phase 1
Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash
Dental Diseases
Cairo University30 enrolled1 locationNCT03384537
Recruiting
Early Phase 1
A Clinical Study of AFN50 in the Treatment of Autoimmune Diseases
Relapsed/Refractory Autoimmune Diseases
Beijing Boren Hospital18 enrolled1 locationNCT07448298
Recruiting
Early Phase 1
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
Sjogren's SyndromeAutoimmune DiseasesIdiopathic Inflammatory Myopathies+3 more
Nanjing Bioheng Biotech Co., Ltd.20 enrolled1 locationNCT06548607
Recruiting
Early Phase 1
Clinical Study of AFN50 Injection in the Autoimmune Diseases
Autoimmune Diseases
AlphaNa Bioscience Company Limited18 enrolled1 locationNCT07408336
Recruiting
Early Phase 1
A Study of CNCT19 in the Treatment of Relapsed or Refractory Neurological Autoimmune Diseases
Neurological Autoimmune Diseases
Juventas Cell Therapy Ltd.18 enrolled1 locationNCT07275736
Recruiting
Early Phase 1
Human Amniotic-Derived Mesenchymal Stem Cell Therapy for Calciphylaxis
EfficacyTreatmentChronic Kidney Diseases+3 more
The First Affiliated Hospital with Nanjing Medical University9 enrolled1 locationNCT04592640
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
Rheumatoid ArthritisSystemic Lupus ErythematosusAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis+3 more
Changhai Hospital60 enrolled1 locationNCT07246096
Recruiting
Early Phase 1
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
Inflammatory Bowel DiseasesPrimary Sclerosing Cholangitis
Stanford University15 enrolled1 locationNCT05912387
Recruiting
Early Phase 1
Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease
Chronic Kidney DiseasesPediatric Kidney Disease
Ann & Robert H Lurie Children's Hospital of Chicago40 enrolled1 locationNCT06430684
Recruiting
Early Phase 1
Exploratory Clinical Study of Second-generation CD19/BCMA Chimeric Antigen Receptor NK Cell Injection in Treating Paediatric B Cell-related Autoimmune Diseases
CARAutoimmune DiseasesPaediatric B Cell-related Autoimmune Diseases
The Children's Hospital of Zhejiang University School of Medicine12 enrolled1 locationNCT07283315
Recruiting
Early Phase 1
Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support
Vascular Diseases
Montefiore Medical Center50 enrolled1 locationNCT06510322