Drug Use Clinical Trials

34 recruitingLast updated: June 18, 2026

There are 34 actively recruiting drug use clinical trials across 14 countries. Studies span Not Applicable, Phase 4, Phase 2. Top locations include Oklahoma City, Oklahoma, United States, New Haven, Connecticut, United States, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Drug Use Trials at a Glance

34 actively recruiting trials for drug use are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 18 trials, with the heaviest enrollment activity in Oklahoma City, New Haven, and Beijing. Lead sponsors running drug use studies include Arizona State University, University of Miami, and University of Michigan.

Browse drug use trials by phase

Treatments under study

About Drug Use Clinical Trials

Looking for clinical trials for Drug Use? There are currently 18 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Drug Use trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Drug Use clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 34 trials

Recruiting
Not Applicable

Feasibility of Internet-based HIV Prevention Research

HIV PreventionInjection Drug Use
Montefiore Medical Center500 enrolled1 locationNCT07625917
Recruiting
Not Applicable

Project REACH: A Comprehensive Telehealth Intervention at Syringe Service Programs to Engage People Who Use Drugs

Substance UseDrug Use
University of Minnesota121 enrolled1 locationNCT07433712
Recruiting
Not Applicable

Families With Pride ("Familias Con Orgullo").

DepressionDrug Use
University of Miami306 enrolled1 locationNCT06057337
Recruiting
Not Applicable

Brain Mechanisms of Reducing Polysubstance Use

Multiple Drug Use
Arizona State University35 enrolled1 locationNCT06324786
Recruiting
Phase 4

Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use

Immune DysregulationHIVSystemic Inflammation+1 more
University of Alabama at Birmingham100 enrolled1 locationNCT06829238
Recruiting
Not Applicable

Harm Reduction Services

Substance AbuseDrug UseMental Illness
NYU Langone Health200 enrolled3 locationsNCT05776316
Recruiting
Phase 4

Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

HIVSubstance Use Disorder (SUD)Injection Drug Use
Massachusetts General Hospital100 enrolled2 locationsNCT07199335
Recruiting

CEDRN: Opioid Registry

Opioid-use DisorderOpioid WithdrawalPolysubstance Abuse+2 more
University of British Columbia7,200 enrolled1 locationNCT07466784
Recruiting
Phase 4

Implementing Low-Barrier HCV Treatment in a Jail Setting

Implementation ScienceIncarcerationInjection Drug Use+1 more
Lifespan40 enrolled1 locationNCT06953479
Recruiting
Phase 2

Family Acceptance Project Online (Pilot RCT)

DepressionAnxietyDrug Use+6 more
University of Michigan180 enrolled1 locationNCT06839859
Recruiting
Not Applicable

Leveraging Parents and Peers to Increase Recovery Capital in Emerging Adults

Polysubstance Drug Use (Indiscriminate Drug Use)
Chestnut Health Systems48 enrolled8 locationsNCT06414993
Recruiting
Not Applicable

Reducing Stigma in People Who Inject Drugs (PWID) With HIV Using a Rapid Start Antiretroviral Therapy Intervention (ART)

HIVDrug Use
Yale University135 enrolled3 locationsNCT06541028
Recruiting
Not Applicable

Lakota Family Acceptance Project

DepressionAnxietyDrug Use+6 more
University of Michigan28 enrolled2 locationsNCT07326748
Recruiting
Not Applicable

Using the LINE@ Online Platform to Follow Up on Illegal Drug Use Among College and University Students

Illegal Drug Use
National Taiwan Normal University30 enrolled1 locationNCT07312591
Recruiting
Not Applicable

Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

Opioid UseHIV InfectionsSubstance Use Disorders+3 more
Johns Hopkins University360 enrolled2 locationsNCT06103370
Recruiting

fMRI and Opioid Abstinence

Opioid UseOpioid DependenceOpioid Abuse+2 more
Yale University240 enrolled1 locationNCT06651333
Recruiting

Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries

HepatitisHIVDrug Use
Médecins du Monde2,400 enrolled9 locationsNCT06395129
Recruiting
Not Applicable

Project Vuselela Feasibility

HIVDrug Users
Arizona State University80 enrolled1 locationNCT07117656
Recruiting
Not Applicable

Mental Health in Primary Care

Depression, AnxietySuicideDrug Use
University of Miami468 enrolled17 locationsNCT05426057
Recruiting
Not Applicable

Effectiveness of ACT for Problematic Chemsex

HypersexualityCompulsive Sexual BehaviorSexualized Drug Use (Chemsex)
Universidad Europea de Madrid22 enrolled1 locationNCT06406296