Phase 1 Esophageal Cancer Clinical Trials
36 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 36 trials
Recruiting
Phase 1Phase 2
Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
Esophageal CancerEsophageal NeoplasmsGastroesophageal Junction+1 more
Merck Sharp & Dohme LLC210 enrolled44 locationsNCT06445972
Recruiting
Phase 1Phase 2
Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
Esophageal CancerEsophageal NeoplasmsGastroesophageal Junction+1 more
Merck Sharp & Dohme LLC160 enrolled50 locationsNCT06469944
Recruiting
Phase 1Phase 2
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Esophageal CancerGastric CancerPancreatic Ductal Adenocarcinoma
Perspective Therapeutics112 enrolled7 locationsNCT06710756
Recruiting
Phase 1
A Phase 1 Study of the Safety and Tolerability of CTX-10726
Endometrial CancerRenal Cell Carcinoma (RCC)Hepatocellular Carcinoma (HCC)+1 more
Compass Therapeutics70 enrolled3 locationsNCT07419841
Recruiting
Phase 1
CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer
Esophageal CancerGastric CancerEsophagus Cancer+1 more
Washington University School of Medicine42 enrolled1 locationNCT05187182
Recruiting
Phase 1
Phase 1 Study of PF-08046033 in Advanced Solid Tumors
Esophageal CancerCutaneous MelanomaNon-Small-Cell Lung
Pfizer250 enrolled6 locationsNCT07519655
Recruiting
Phase 1
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
Esophageal CancerGastric CancerCervical Cancer+5 more
Genentech, Inc.450 enrolled41 locationsNCT05581004
Recruiting
Phase 1
A Phase 1/1b Study of IAM1363 in HER2 Cancers
HER2-positive Breast CancerHER2 + Breast CancerHER2 Mutation-Related Tumors+10 more
Iambic Therapeutics, Inc383 enrolled48 locationsNCT06253871
Recruiting
Phase 1
A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
Gastric AdenocarcinomaBladder CancerMesothelioma+7 more
IDEAYA Biosciences260 enrolled10 locationsNCT07277413
Recruiting
Phase 1
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
Breast CancerEsophageal CancerGastric Cancer+7 more
SystImmune Inc.280 enrolled17 locationsNCT06293898
Recruiting
Phase 1
A Phase 1 First-In-Human Study of the Anti-CD73 IPH5301 Alone or in Combination With Chemotherapy and Trastuzumab in Patients With Advanced Solid Tumors
Metastatic Breast CancerEndometrial CancerAdvanced Solid Tumor+6 more
Institut Paoli-Calmettes27 enrolled1 locationNCT05143970
Recruiting
Phase 1Phase 2
Clinical Trial Evaluating TQB6411 Injection in Subjects With Esophageal Cancer
Esophageal Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.105 enrolled30 locationsNCT07367516
Recruiting
Phase 1
Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors
Breast CancerEsophageal CancerGastric Cancer+4 more
Baylor College of Medicine45 enrolled1 locationNCT03740256
Recruiting
Phase 1
A Study of SH009 Injection in Patients With Advanced Solid Tumors.
Esophageal CancerBreast Cancer (Locally Advanced or Metastatic)Lung Cancer (NSCLC)+4 more
Nanjing Sanhome Pharmaceutical, Co., Ltd.150 enrolled1 locationNCT07390838
Recruiting
Phase 1
MR-Guided Radiotherapy Dose Escalation Trial for Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma (ESCC)Esophageal Cancer, Squamous Cell
UMC Utrecht30 enrolled1 locationNCT07359417
Recruiting
Phase 1
A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors
Esophageal CancerProstate CancerLung Cancer (NSCLC)+1 more
Phrontline Biopharma200 enrolled7 locationsNCT07181473
Recruiting
Phase 1Phase 2
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Breast CancerEsophageal CancerGastric Cancer+13 more
Tanabe Pharma America, Inc.27 enrolled6 locationsNCT06943521
Recruiting
Phase 1Phase 2
Oncolytic Virus in Esophageal Squamous Cell Carcinoma
Esophageal Cancer
Sichuan University40 enrolled1 locationNCT07061704
Recruiting
Phase 1
18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer
Esophageal Cancer
M.D. Anderson Cancer Center60 enrolled1 locationNCT06414902
Recruiting
Phase 1
CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors
Esophageal CancerGastric CancerLung Cancer+3 more
Chongqing Precision Biotech Co., Ltd108 enrolled1 locationNCT07179692