Germ Cell Tumor Clinical Trials

37 recruitingLast updated: June 17, 2026

There are 37 actively recruiting germ cell tumor clinical trials across 27 countries. Studies span Phase 2, Phase 1, Not Applicable, Phase 3, Early Phase 1. Top locations include Minneapolis, Minnesota, United States, New York, New York, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Germ Cell Tumor Trials at a Glance

37 actively recruiting trials for germ cell tumor are listed on ClinicalTrialsFinder across 6 cities in 27 countries. The largest study group is Phase 2 with 13 trials, with the heaviest enrollment activity in Minneapolis, New York, and Houston. Lead sponsors running germ cell tumor studies include Children's Oncology Group, Gustave Roussy, Cancer Campus, Grand Paris, and Chengcheng Guo.

Browse germ cell tumor trials by phase

Treatments under study

About Germ Cell Tumor Clinical Trials

Looking for clinical trials for Germ Cell Tumor? There are currently 23 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Germ Cell Tumor trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Germ Cell Tumor clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 37 trials

Recruiting
Phase 2

Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)

Squamous Cell Carcinoma of the BladderAdenocarcinoma of the BladderTesticular Germ Cell Tumors
National Cancer Institute (NCI)68 enrolled1 locationNCT06041503
Recruiting
Not Applicable

Research of Double-positive Circulating Cells (Tumor Marker / CD45+) in Several Types of Metastatic Cancers

Urothelial CarcinomaCervical CarcinomaCutaneous Melanoma+7 more
Institut Claudius Regaud450 enrolled1 locationNCT06967961
Recruiting
Phase 1

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

Ovarian CancerEndometrial CancerGerm Cell Tumor+2 more
Xencor, Inc.282 enrolled18 locationsNCT06276491
Recruiting
Phase 1Phase 2

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

Hodgkin LymphomaMultiple MyelomaAcute Myeloid Leukemia (AML)+7 more
M.D. Anderson Cancer Center80 enrolled1 locationNCT05092451
Recruiting
Early Phase 1

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

transitional cell carcinomaSoft Tissue SarcomaMelanoma+12 more
University of California, Irvine25 enrolled1 locationNCT07628634
Recruiting
Phase 1Phase 2

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting
Phase 1

A Study of ZW251 in Participants With Advanced Solid Tumors

Hepatocellular CarcinomaGerm Cell TumorSquamous Cell Non Small Cell Lung Cancer
Zymeworks BC Inc.100 enrolled25 locationsNCT07164313
Recruiting
Phase 2

Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

Germ Cell TumorOvarian Germ Cell TumorNon-seminomatous Germ Cell Tumor
Nabil Adra64 enrolled1 locationNCT04804007
Recruiting
Phase 3

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

Germ Cell TumorChildhood Extracranial Germ Cell TumorExtragonadal Embryonal Carcinoma+27 more
Children's Oncology Group1,780 enrolled629 locationsNCT03067181
Recruiting
Phase 2

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

Central Nervous System Nongerminomatous Germ Cell TumorChoriocarcinomaEmbryonal Carcinoma+7 more
Children's Oncology Group160 enrolled166 locationsNCT04684368
Recruiting
Not Applicable

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

MelanomaBreast Cancer, NOSCNS Primary Tumor, NOS+9 more
Eastern Cooperative Oncology Group400 enrolled347 locationsNCT05108298
Recruiting

Tumor-Lymph Node Mapping

SarcomaGerm Cell TumorRhabdomyosarcoma+1 more
University of Rochester10 enrolled1 locationNCT07054944
Recruiting
Phase 1

Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors

Hearing LossMetastatic Malignant Germ Cell TumorMetastatic Malignant Nongerminomatous Germ Cell Tumor+4 more
City of Hope Medical Center44 enrolled1 locationNCT07218913
Recruiting
Phase 2

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

Advanced Colorectal CarcinomaAdvanced Anal CarcinomaAdvanced Biliary Tract Carcinoma+41 more
Mayo Clinic220 enrolled2 locationsNCT05969860
Recruiting
Phase 1

Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Germ Cell TumorEwing SarcomaNeuroblastoma+3 more
New York Medical College30 enrolled1 locationNCT04308330
Recruiting

MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease Trial

Malignant Testicular Germ Cell Tumor
University of Southern California418 enrolled5 locationsNCT06060873
Recruiting
Phase 1

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Germ Cell TumorChoroid Plexus CarcinomaCentral Nervous System Tumor+8 more
Seattle Children's Hospital90 enrolled1 locationNCT04185038
Recruiting
Phase 2

Assessment of Compliance With Monitoring Conducted by a Physician in Person or by a Nurse in Remote Monitoring

Carcinoma, Small CellNeuroendocrine TumorsGastrointestinal Stromal Tumors+11 more
Centre Oscar Lambret88 enrolled3 locationsNCT05500391
Recruiting

A Prospective Study to Evaluate miRNA371 and Outcomes in Patients With Newly Diagnosed Germ Cell Tumors

Testicular Germ Cell Tumor
Fondazione del Piemonte per l'Oncologia100 enrolled1 locationNCT07453082
Recruiting

Germ Cell Tumor and Testicular Tumor DNA Registry

Germ Cell TumorTesticular Tumor
Memorial Sloan Kettering Cancer Center1,000 enrolled8 locationsNCT02099734