Germ Cell Tumor Clinical Trials

21 recruiting

Germ Cell Tumor Trials at a Glance

33 actively recruiting trials for germ cell tumor are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Phase 2 with 12 trials, with the heaviest enrollment activity in Indianapolis, Minneapolis, and New York. Lead sponsors running germ cell tumor studies include Children's Oncology Group, Gustave Roussy, Cancer Campus, Grand Paris, and Chengcheng Guo.

Browse germ cell tumor trials by phase

Treatments under study

About Germ Cell Tumor Clinical Trials

Looking for clinical trials for Germ Cell Tumor? There are currently 21 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Germ Cell Tumor trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Germ Cell Tumor clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 33 trials

Recruiting

Tumor-Lymph Node Mapping

SarcomaGerm Cell TumorRhabdomyosarcoma+1 more
University of Rochester10 enrolled1 locationNCT07054944
Recruiting
Phase 1

Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors

Hearing LossMetastatic Malignant Germ Cell TumorMetastatic Malignant Nongerminomatous Germ Cell Tumor+4 more
City of Hope Medical Center44 enrolled1 locationNCT07218913
Recruiting
Phase 2

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

Advanced Colorectal CarcinomaAdvanced Anal CarcinomaAdvanced Biliary Tract Carcinoma+41 more
Mayo Clinic220 enrolled2 locationsNCT05969860
Recruiting
Phase 1

Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Germ Cell TumorEwing SarcomaNeuroblastoma+3 more
New York Medical College30 enrolled1 locationNCT04308330
Recruiting
Phase 1Phase 2

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting

MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease Trial

Malignant Testicular Germ Cell Tumor
University of Southern California418 enrolled5 locationsNCT06060873
Recruiting
Phase 1

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Germ Cell TumorChoroid Plexus CarcinomaCentral Nervous System Tumor+8 more
Seattle Children's Hospital90 enrolled1 locationNCT04185038
Recruiting
Phase 3

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

Germ Cell TumorChildhood Extracranial Germ Cell TumorExtragonadal Embryonal Carcinoma+27 more
Children's Oncology Group1,780 enrolled630 locationsNCT03067181
Recruiting
Not Applicable

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

MelanomaBreast Cancer, NOSCNS Primary Tumor, NOS+9 more
Eastern Cooperative Oncology Group400 enrolled347 locationsNCT05108298
Recruiting
Phase 2

Assessment of Compliance With Monitoring Conducted by a Physician in Person or by a Nurse in Remote Monitoring

Carcinoma, Small CellNeuroendocrine TumorsGastrointestinal Stromal Tumors+11 more
Centre Oscar Lambret88 enrolled3 locationsNCT05500391
Recruiting
Phase 1

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

Ovarian CancerEndometrial CancerGerm Cell Tumor+2 more
Xencor, Inc.282 enrolled16 locationsNCT06276491
Recruiting

A Prospective Study to Evaluate miRNA371 and Outcomes in Patients With Newly Diagnosed Germ Cell Tumors

Testicular Germ Cell Tumor
Fondazione del Piemonte per l'Oncologia100 enrolled1 locationNCT07453082
Recruiting
Phase 2

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

Central Nervous System Nongerminomatous Germ Cell TumorChoriocarcinomaEmbryonal Carcinoma+7 more
Children's Oncology Group160 enrolled165 locationsNCT04684368
Recruiting

Germ Cell Tumor and Testicular Tumor DNA Registry

Germ Cell TumorTesticular Tumor
Memorial Sloan Kettering Cancer Center1,000 enrolled8 locationsNCT02099734
Recruiting
Phase 2

A Single-arm, Phase II Clinical Trial of ASPIRin to prEvent Venous Thromboembolism in Patients With Advanced Germ Cell Tumors Receiving Chemotherapy

Germ Cell TumorTesticular Cancer
Wake Forest University Health Sciences35 enrolled3 locationsNCT06866964
Recruiting
Phase 2

Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)

Squamous Cell Carcinoma of the BladderAdenocarcinoma of the BladderTesticular Germ Cell Tumors
National Cancer Institute (NCI)68 enrolled1 locationNCT06041503
Recruiting

Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification

Germ Cell TumorGliomaEpendymoma+10 more
European Organisation for Research and Treatment of Cancer - EORTC1,650 enrolled42 locationsNCT05259605
Recruiting
Phase 1Phase 2

Maintenance Zanzalintinib With Etoposide After HDCT in GCT

Germ Cell Tumor
Indiana University38 enrolled1 locationNCT06937866
Recruiting

Molecular Epidemiology of Pediatric Germ Cell Tumors

GerminomaGerm Cell TumorTeratoma+6 more
Children's Oncology Group1,151 enrolled1 locationNCT05564026
Recruiting
Phase 2

Treatment of Newly Diagnosed Central Malignant Germ Cell Tumor People With Teniposide Injection Combined With Cisplatin.

Germ Cell TumorGCTCentral Malignant Germ Cell Tumor
Chengcheng Guo40 enrolled1 locationNCT07188441