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Healthy Volunteers Clinical Trials

243 recruitingLast updated: June 15, 2026

There are 243 actively recruiting healthy volunteers clinical trials across 39 countries. Studies span Phase 1, Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 4. Top locations include Bethesda, Maryland, United States, Melbourne, Victoria, Australia, London, United Kingdom. Updated daily from ClinicalTrials.gov.


Healthy Volunteers Trials at a Glance

243 actively recruiting trials for healthy volunteers are listed on ClinicalTrialsFinder across 6 cities in 39 countries. The largest study group is Phase 1 with 121 trials, with the heaviest enrollment activity in Bethesda, Melbourne, and London. Lead sponsors running healthy volunteers studies include Bristol-Myers Squibb, Hospices Civils de Lyon, and AbbVie.

Browse healthy volunteers trials by phase

Treatments under study

About Healthy Volunteers Clinical Trials

Looking for clinical trials for Healthy Volunteers? There are currently 217 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Healthy Volunteers trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Healthy Volunteers clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 243 trials

Recruiting

Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

Healthy Volunteers
National Heart, Lung, and Blood Institute (NHLBI)1,000 enrolled1 locationNCT00442195
Recruiting
Phase 2

Neurobiology of Suicide

DepressionHealthy Volunteers
National Institute of Mental Health (NIMH)325 enrolled1 locationNCT02543983
Recruiting
Phase 1

A Study to Assess the Drug Levels and Safety of BMS-986435 in Participants With Normal Hepatic Function and Participants With Different Degrees of Hepatic Impairment

Healthy VolunteersHepatic Impairment
Bristol-Myers Squibb24 enrolled3 locationsNCT07248839
Recruiting
Phase 1

A Study to Evaluate ALN-4915 in Adult Healthy Volunteers

Healthy Volunteers
Alnylam Pharmaceuticals44 enrolled1 locationNCT07535606
Recruiting
Not Applicable

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

ObesityHealthy VolunteersNormal Physiology
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)120 enrolled1 locationNCT05545306
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 1

A Study to Evaluate ALN-4285 in Adult Healthy Volunteers

Healthy Volunteers
Alnylam Pharmaceuticals76 enrolled1 locationNCT07295717
Recruiting
Phase 1

Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake

Healthy VolunteersDiet Therapy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)60 enrolled1 locationNCT04799301
Recruiting
Phase 1

A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin

Healthy Volunteers
Karuna Therapeutics, Inc., a Bristol Myers Squibb company60 enrolled1 locationNCT07118215
Recruiting
Phase 1

A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults

Healthy Volunteers
Otsuka Pharmaceutical Development & Commercialization, Inc.18 enrolled1 locationNCT07329621
Recruiting
Not Applicable

Mechanism of Non-invasive Magnetic Stimulation

Healthy Volunteers
National Institute on Drug Abuse (NIDA)70 enrolled1 locationNCT03394066
Recruiting
Not Applicable

Generalization and Specificity of Visual Learning During Sleep

Healthy VolunteersVisual Learning
Brown University10 enrolled1 locationNCT07015840
Recruiting
Phase 1

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PRO-203 in Healthy Volunteers and Participants With Systemic Sclerosis

Healthy VolunteersSclerodermaSystemic Sclerosis (SSc)+1 more
Prolium Bioscience, Inc74 enrolled2 locationsNCT07641634
Recruiting

Cytapheresis of Volunteer Donors

Healthy Volunteers
National Institute on Aging (NIA)10,000 enrolled1 locationNCT00104325
Recruiting
Not Applicable

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

PainHealthy VolunteersNormal Physiology
National Center for Complementary and Integrative Health (NCCIH)700 enrolled1 locationNCT03258580
Recruiting

Children s Growth and Behavior Study

ObesityHealthy VolunteersEating Behaviors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)1,500 enrolled1 locationNCT02390765
Recruiting

Physical and Behavioral Traits of Overweight and Obese Adults

ObesityHealthy Volunteers
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2,000 enrolled1 locationNCT00428987
Recruiting

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

DepressionHealthy VolunteersAnxiety Disorders+2 more
National Institute of Mental Health (NIMH)16,000 enrolled1 locationNCT00024635
Recruiting
Phase 2

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

Healthy VolunteersOverweight
National Institute on Alcohol Abuse and Alcoholism (NIAAA)150 enrolled1 locationNCT03407079
Recruiting

Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies

Healthy VolunteersHIV
National Institute of Allergy and Infectious Diseases (NIAID)3,000 enrolled1 locationNCT00114647