Phase 2 Male Clinical Trials

48 recruitingPhase 2

What is a Phase 2 trial?

Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.

Showing 120 of 48 trials

Recruiting
Phase 2

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Malignant Solid NeoplasmMalignant Female Reproductive System NeoplasmRecurrent Malignant Solid Neoplasm+1 more
National Cancer Institute (NCI)70 enrolled185 locationsNCT06126276
Recruiting
Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Malignant Female Reproductive System Neoplasm+12 more
National Cancer Institute (NCI)2,900 enrolled479 locationsNCT05564377
Recruiting
Phase 2

ETHAN - ET for Male BC

Male Breast Cancer
Jose Pablo Leone60 enrolled8 locationsNCT05501704
Recruiting
Phase 2

Testosterone Treatment in Men With Chronic Kidney Disease

Hypogonadism, MaleKidney Disease, Chronic
St. Louis University20 enrolled1 locationNCT05249634
Recruiting
Phase 1Phase 2

Open-Label Study of Pocenbrodib Alone and in Combination With Abiraterone Acetate, Olaparib, or 177Lu-PSMA-617

Prostate CancerNeoplasmsNeoplasms by Site+7 more
Pathos AI, Inc.252 enrolled18 locationsNCT06785636
Recruiting
Phase 2Phase 3

Uterine Transplant in Absolute Uterine Infertility (AUIF)

Female Infertility
Brigham and Women's Hospital10 enrolled1 locationNCT02741102
Recruiting
Phase 2

Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

Anal CarcinomaCervical CarcinomaVaginal Carcinoma+3 more
Ohio State University Comprehensive Cancer Center25 enrolled1 locationNCT07407647
Recruiting
Phase 2

Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism

PainOpioid UseHypogonadism, Male
Brigham and Women's Hospital150 enrolled1 locationNCT04798469
Recruiting
Phase 1Phase 2

Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer

Prostate CancermCRPC (Metastatic Castration-resistant Prostate Cancer)Prostatic Neoplasms, Castration-Resistant+3 more
Celcuity Inc54 enrolled13 locationsNCT06190899
Recruiting
Phase 1Phase 2

ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer

Breast CancerMetastatic Breast CancerBreast Cancer Female+2 more
Sarah Sammons, MD65 enrolled1 locationNCT07198724
Recruiting
Phase 2

Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency

CancerFatigueHypogonadism, Male
Seattle Institute for Biomedical and Clinical Research230 enrolled3 locationsNCT04301765
Recruiting
Phase 2

Microbiome and Association With Implant Infections

Breast CancerBreast Cancer FemaleGenetic Predisposition to Disease
University of California, San Francisco200 enrolled1 locationNCT05020574
Recruiting
Phase 2

Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal or Gynecological Cancer

Malignant Female Reproductive System NeoplasmMalignant Digestive System Neoplasm
Mayo Clinic34 enrolled1 locationNCT06855524
Recruiting
Phase 1Phase 2

Open Label, Dose Escalation, Repeat Dose Study Evaluating YCT-529 in Healthy Males

Male Contraception
YourChoice Therapeutics, Inc.88 enrolled1 locationNCT06542237
Recruiting
Phase 2

Effects of NLS-133, a Potential Non-Hormonal "On-Demand" Male Contraceptive

Male ContraceptionSemen VolumeSperm Motility
Next Life Sciences10 enrolled1 locationNCT07393334
Recruiting
Phase 2Phase 3

Benefit of GnRH Agonist Before Frozen Embryo Transfer in Patients With Endometriosis and/or Adenomyosis

EndometriosisInfertility, FemaleAdenomyosis
Hopital Foch180 enrolled1 locationNCT04356664
Recruiting
Phase 2

Plan A Occlusion and Reversal System Feasibility Study

FertilityFertility, MaleHealthy Male Adults
Next Life Sciences40 enrolled1 locationNCT07361120
Recruiting
Phase 2

Dostarlimab, Cisplatin and Etoposide in Combination With Radiotherapy in Sandwich Sequence for Small Cell Neuroendocrine Cervical Carcinoma

Female
Chang Gung Memorial Hospital45 enrolled1 locationNCT07336147
Recruiting
Phase 2

Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer

Penile CancerUrogenital NeoplasmsPenile Squamous Cell Carcinoma+3 more
The Netherlands Cancer Institute27 enrolled2 locationsNCT06353906
Recruiting
Phase 2

IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal Metastases

Breast CancerFemale Breast CancerMastectomy; Lymphedema+3 more
Alice Chung45 enrolled3 locationsNCT06092892