Phase 3 Metastatic Colorectal Cancer Clinical Trials
19 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–19 of 19 trials
Recruiting
Phase 3
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Metastatic Colorectal Cancer
EMD Serono Research & Development Institute, Inc.1,020 enrolled8 locationsNCT07549412
Recruiting
Phase 3
Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment
Unresectable Metastatic Colorectal Cancer
University Hospital, Tours244 enrolled4 locationsNCT06642844
Recruiting
Phase 3
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Metastatic Colorectal Cancer
Amgen450 enrolled290 locationsNCT06252649
Recruiting
Phase 2Phase 3
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Untreated, Unresectable, or Metastatic Colorectal Cancer
Bristol-Myers Squibb990 enrolled286 locationsNCT07221357
Recruiting
Phase 3
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Metastatic Colorectal Cancer (CRC)
Summit Therapeutics600 enrolled76 locationsNCT07228832
Recruiting
Phase 3
A Study of HX008 Compared to Chemotherapy in the First-Line Treatment of Subjects With MSI-H/dMMR Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
Taizhou Hanzhong biomedical co. LTD190 enrolled63 locationsNCT05652894
Recruiting
Phase 3
Continuation of Cetuximab Beyond First-Line Progression in Metastatic Colorectal Cancer
Metastatic Colorectal Cancer (Mcrc)
University of Campania Luigi Vanvitelli480 enrolled41 locationsNCT07389265
Recruiting
Phase 3
A Phase Ib/III Study of Suvemcitug Plus FTD/TPI in Participants With Refractory Metastatic Colorectal Cancer
Refractory Metastatic Colorectal Cancer
Jiangsu Simcere Pharmaceutical Co., Ltd.464 enrolled6 locationsNCT07361003
Recruiting
Phase 3
NALIRIFOX Plus Targeted Therapy Versus FOLFOX Plus Targeted Therapy as First-line Treatment for Metastatic Colorectal Cancer
Metastatic Colorectal Cancer (CRC)
Shanghai Zhongshan Hospital144 enrolled1 locationNCT07309289
Recruiting
Phase 3
Study in mCRC Patients RAS/BRAF wt Tissue and RAS Mutated LIquid BIopsy to Compare FOLFIRI Plus CetuxiMAb or BevacizumaB
Colorectal, CancerMetastatic Colorectal CancerRAS Mutation
Azienda USL Reggio Emilia - IRCCS280 enrolled4 locationsNCT04776655
Recruiting
Phase 3
A Study Assessing Adverse Events and Disease Activity When Comparing Intravenously (IV) Infused ABBV-400 to Trifluridine and Tipiracil (LONSURF) Oral Tablets Plus IV Infused Bevacizumab in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
AbbVie460 enrolled51 locationsNCT06614192
Recruiting
Phase 2Phase 3
Node-Sparing Short-Course Radiotherapy Plus Chemotherapy, Bevacizumab and PD-1 Inhibitor in Metastatic pMMR/MSS Colorectal Cancer (MODIFI-CRC)
RadiotherapyMetastatic Colorectal Cancer (CRC)Immune Checkpoint Therapy
Sixth Affiliated Hospital, Sun Yat-sen University286 enrolled1 locationNCT06958419
Recruiting
Phase 2Phase 3
Regorafenib With Low-dose Chemotherapies and Aspirin Followed by Standard Chemotherapies in Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
Centre Hospitalier Universitaire de Besancon446 enrolled16 locationsNCT05462613
Recruiting
Phase 2Phase 3
A Clinical Study to Evaluate Efficacy and Safety of Serplulimab（HLX10） Combined With Bevacizumab（HLX04) and Chemotherapy (XELOX) in Patients With Metastatic Colorectal Cancer (mCRC)
Metastatic Colorectal Cancer
Shanghai Henlius Biotech568 enrolled5 locationsNCT04547166
Recruiting
Phase 2Phase 3
Sacituzumab Govitecan in Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
University Hospital Heidelberg80 enrolled1 locationNCT06243393
Recruiting
Phase 3
A Study of Systemic Chemotherapy With/Without HAI in Patients With Initially Unresectable Colorectal Liver Metastasis
Metastatic Colorectal Cancer
Yuhong Li142 enrolled1 locationNCT02102789
Recruiting
Phase 3
Sulfasalazine in Patients With Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
Tanta University50 enrolled1 locationNCT06134388
Recruiting
Phase 3
Nitazoxanide in Patients With Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
Tanta University60 enrolled1 locationNCT06049901
Recruiting
Phase 3
Brivanib and Cetuximab versus Cetuximab and Placebo in treating patients with metastatic colorectal cancer who have been previously treated with combination chemotherapy
Metastatic Colorectal Cancer
Australasian Gastro-Intestinal Trials Group (AGITG)750 enrolled3 locationsACTRN12607000589482