Phase 3 Opioid Clinical Trials
22 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 22 trials
Recruiting
Phase 3
Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement
Opioid UseTobacco UsePolysubstance Abuse
Rutgers, The State University of New Jersey420 enrolled2 locationsNCT06033599
Recruiting
Phase 3
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
Opioid UsePain, PostoperativePain, Back+1 more
Hospital for Special Surgery, New York150 enrolled1 locationNCT05058287
Recruiting
Phase 3
Post-Op Pain Control for Prophylactic Intramedullary Nailing.
PainBone MetastasesOpioid Use+2 more
St. Louis University60 enrolled1 locationNCT03823534
Recruiting
Phase 3
Opioid-Sparing Joint Replacement
Pain ManagementOpioid Consumption
Emory University120 enrolled1 locationNCT07348627
Recruiting
Phase 3
Smartphones for Opiate Addiction Recovery
Opioid-use Disorder
NYU Langone Health225 enrolled2 locationsNCT05033028
Recruiting
Phase 3
Optimizing Pain Treatment in Children On Mechanical Ventilation
Mechanical VentilationSedation and AnalgesiaAnalgesics, Opioid+1 more
Weill Medical College of Cornell University644 enrolled15 locationsNCT06994442
Recruiting
Phase 3
Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)
Prostate CancerOpioid Consumption, PostoperativeMultimodal Analgesia+2 more
Brigham and Women's Hospital300 enrolled2 locationsNCT07427043
Recruiting
Phase 3
Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
Misuse, Opioid
M.D. Anderson Cancer Center87 enrolled1 locationNCT06200181
Recruiting
Phase 3
Treating Polysubstance Use Using a Novel Digital Technology
Opioid Use
Friends Research Institute, Inc.240 enrolled5 locationsNCT05766631
Recruiting
Phase 3
Adjunctive Cannabidiol for Recovery From Opioid Study
Opioid Use Disorder (OUD)
Icahn School of Medicine at Mount Sinai450 enrolled2 locationsNCT06940674
Recruiting
Phase 3
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
PainOpioid Use
Rutgers, The State University of New Jersey450 enrolled2 locationsNCT06032559
Recruiting
Phase 2Phase 3
Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments
Opioid-use Disorder
University of British Columbia658 enrolled6 locationsNCT04893525
Recruiting
Phase 2Phase 3
Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder
Opioid-use Disorder
New York State Psychiatric Institute180 enrolled2 locationsNCT05011266
Recruiting
Phase 2Phase 3
Perioperative Analgesia Modes in Minimally Invasive Esophagectomy
Esophageal CancerPerioperative AnalgesiaNSAIDs+2 more
Cancer Institute and Hospital, Chinese Academy of Medical Sciences102 enrolled1 locationNCT05504265
Recruiting
Phase 3
Perioperative Dexamethasone Reduces Postoperative Pain and Nausea After Periacetabular Osteotomy
PainPostoperative NauseaAmount of Postoperative Opioid Use in Milligrams
Balgrist University Hospital60 enrolled1 locationNCT05120076
Recruiting
Phase 2Phase 3
Laparoscopic Guided Peri-wound Transversus Abdominis Plane Block With Bupivacaine Versus Local Wound Infiltration on Post-op Opioid Use in Laparoscopic Sleeve Gastrectomy
Opioid UseMorbid ObesityTransversus Abdominis Plane Block+3 more
Khon Kaen University98 enrolled1 locationNCT05930184
Completed
Phase 3
The Depot Evaluation Buprenorphine Utilization Trial (DEBUT)
Opioid dependent
Camurus AB120 enrolled6 locationsACTRN12618001759280
Completed
Phase 3Phase 4
Optimising Management of acute pain in Opioid Substitution Therapy patients: A pilot laboratory randomised study
Acute pain in opioid dependence
Sydney Local Health District - Royal Prince Alfred Hospital36 enrolled1 locationACTRN12612000288820
Terminated
Phase 3
Opioids for breathlessness in people with mesothelioma or asbestosis or other causes of interstitial lung disease.
Dyspnoea in opioid naive participants with mesothelioma or asbestosis or other causes of interstitial lung disease.
Flinders University - Department of Palliative and Support Services144 enrolled3 locationsACTRN12611000711910
Active
Phase 3
A study to evaluate whether increased codeine levels are seen when both codeine and ketamine are given in small doses to well volunteers.
The possibility that ketamine,an anaesthetic medication but which is also used at much lower doses, to help try and control severe chronic nerve pain, may increase the effective blood levels of opioids such as codeine or morphine that are often given in conjunction with ketamine.This study is looking at drug metabolism not pain management or anaesthesiology
Flinders University- Department of Clinical Pharmacology10 enrolled1 locationACTRN12610000283077