Opioid Clinical Trials

338 recruitingLast updated: June 18, 2026

There are 338 actively recruiting opioid clinical trials across 41 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include Baltimore, Maryland, United States, Boston, Massachusetts, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Opioid Trials at a Glance

338 actively recruiting trials for opioid are listed on ClinicalTrialsFinder across 6 cities in 41 countries. The largest study group is Not Applicable with 172 trials, with the heaviest enrollment activity in Baltimore, Boston, and New York. Lead sponsors running opioid studies include Yale University, University of Pennsylvania, and Medical University of South Carolina.

Treatments under study

About Opioid Clinical Trials

Looking for clinical trials for Opioid? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Opioid trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Opioid clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 338 trials

Recruiting
Phase 4

Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair

Opioid UsePostoperative PainAnesthesia+5 more
University of Crete40 enrolled1 locationNCT04894864
Recruiting
Phase 4

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

Opioid-use DisorderHIV
University of Connecticut256 enrolled1 locationNCT05669534
Recruiting

Opioid Use Disorder and Pain

Opioid-use DisorderHealthy Controls Group - Age and Sex-matched
Yale University180 enrolled1 locationNCT06800703
Recruiting
Not Applicable

Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery

SurgeryPain ManagementPatient-controlled Analgesia+1 more
Beijing Tiantan Hospital1,170 enrolled1 locationNCT07361822
Recruiting
Not Applicable

Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

Opioid-use Disorder
University of California, Davis3,492 enrolled4 locationsNCT07024498
Recruiting
Not Applicable

Adaptive Decision Support for Addiction Treatment Master

Opioid-use Disorder
Yale University1,912 enrolled3 locationsNCT06799117
Recruiting
Not Applicable

Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain

Postoperative PainOpioid Consumption, PostoperativePostoperative Nausea and Vomiting (PONV)
Federal University of Bahia174 enrolled1 locationNCT07633444
Recruiting
Not Applicable

Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

Opioid UseOpioid-use DisorderAlcohol Use Disorder+1 more
University of Notre Dame60 enrolled1 locationNCT07342504
Recruiting

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

Drug addictionOpioid-Related Disorders
National Institute on Drug Abuse (NIDA)150 enrolled1 locationNCT03745339
Recruiting
Not Applicable

Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

Opioid-use DisorderParent-Child Relations
Stony Brook University80 enrolled2 locationsNCT07632053
Recruiting
Phase 3

Suzetrigine in Total Hip Arthroplasty

Total Hip Replacement SurgeryPainPain Management+13 more
Hospital for Special Surgery, New York210 enrolled1 locationNCT07226700
Recruiting
Phase 3

Buprenorphine for Individuals in Jail

Opioid-use Disorder
Friends Research Institute, Inc.240 enrolled2 locationsNCT06306443
Recruiting
Not Applicable

Supporting Treatment Access and Recovery in COD

Mental Health DisorderOpioid-use Disorder
University of Massachusetts, Worcester1,000 enrolled5 locationsNCT05138614
Recruiting
Phase 2

A Study of Brenipatide in Participants With Opioid Use Disorder

Opioid-use Disorder
Eli Lilly and Company465 enrolled57 locationsNCT07420283
Recruiting
Not Applicable

Neuroimaging of Opioid Phase (OPAL)

Opioid UseChronic Pain
Duke University140 enrolled1 locationNCT05905419
Recruiting
Phase 4

Opioid Use After Laparoscopic Salpingectomy

Opioid UsePost Operative PainSterility, Female
Johns Hopkins University38 enrolled1 locationNCT06434233
Recruiting
Not Applicable

Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery

Post Traumatic Stress Disorder (PTSD)Opioid-use DisorderIntimate Partner Violence (IPV)
Yale University532 enrolled3 locationsNCT07115030
Recruiting
Phase 4

Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women

Opioid-use DisorderHIVeHealth
Yale University250 enrolled2 locationsNCT05547048
Recruiting

Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

Opioid-use DisorderOpioid Withdrawal
Spark Biomedical, Inc.20 enrolled2 locationsNCT06487533
Recruiting
Not Applicable

Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy

Opioid UseMastectomy; LymphedemaChronic Pain+1 more
American University of Beirut Medical Center132 enrolled1 locationNCT07561411