Opioid Clinical Trials

5 recruiting

Opioid Trials at a Glance

173 actively recruiting trials for opioid are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Not Applicable with 88 trials, with the heaviest enrollment activity in New York, Baltimore, and Pittsburgh. Lead sponsors running opioid studies include Yale University, VA Office of Research and Development, and University of Pennsylvania.

Browse opioid trials by phase

Treatments under study

About Opioid Clinical Trials

Looking for clinical trials for Opioid? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Opioid trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Opioid clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 173 trials

Recruiting

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

Opioid-Related Disorders
National Institute on Drug Abuse (NIDA)150 enrolled1 locationNCT03745339
Recruiting
Phase 3

Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement

Opioid UseTobacco UsePolysubstance Abuse
Rutgers, The State University of New Jersey420 enrolled2 locationsNCT06033599
Recruiting

Mapping Ibogaine Neural Dynamics in Opioid Use Disorder

Opioid Use Disorder (OUD)
University of California, Irvine20 enrolled1 locationNCT07226570
Recruiting
Not Applicable

Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids

Bariatric Surgery CandidateOpioid Use, Unspecified
G.Gennimatas General Hospital70 enrolled1 locationNCT05752799
Recruiting
Not Applicable

Reducing Opioid Use for Chronic Pain Patients Following Surgery

Opioid UsePostoperative PainChronic Pain+1 more
University Health Network, Toronto210 enrolled1 locationNCT03675386
Recruiting

Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

Healthy ControlSchizophreniaPost Traumatic Stress Disorder+4 more
Yale University100 enrolled1 locationNCT01730781
Recruiting
Phase 1Phase 2

Safety and Pharmacokinetics Study of Naldemedine in Paediatric Participants Receiving Opioids

Opioid-Induced Constipation (OIC)
Shionogi24 enrolled16 locationsNCT05588323
Recruiting
Phase 3

Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression

Opioid UsePain, PostoperativePain, Back+1 more
Hospital for Special Surgery, New York150 enrolled1 locationNCT05058287
Recruiting

Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants

IncarcerationNon-communicable Diseases (NCD)Addiction to Opioids+1 more
University of Thessaly2,000 enrolled5 locationsNCT07558187
Recruiting
Not Applicable

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

Substance-Related DisordersTreatment AdherenceRetention in Care+2 more
University of Maryland, College Park160 enrolled4 locationsNCT05973838
Recruiting
Phase 1Phase 2

Clinical Trials of Multivalent Opioid Vaccine Components

Opioid-use Disorder
New York State Psychiatric Institute45 enrolled2 locationsNCT04458545
Recruiting
Phase 3

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

PainBone MetastasesOpioid Use+2 more
St. Louis University60 enrolled1 locationNCT03823534
Recruiting
Not Applicable

Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain

Opioid UseChronic InsomniaChronic Pain
University of South Florida165 enrolled1 locationNCT06345872
Recruiting
Phase 2

Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder

Magnetic Resonance ImagingEcological Momentary AssessmentAttentional Bias+4 more
University of Arkansas255 enrolled1 locationNCT05336188
Recruiting
Phase 3

Opioid-Sparing Joint Replacement

Pain ManagementOpioid Consumption
Emory University120 enrolled1 locationNCT07348627
Recruiting
Phase 2

Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism

PainOpioid UseHypogonadism, Male
Brigham and Women's Hospital150 enrolled1 locationNCT04798469
Recruiting
Not Applicable

Evaluation of Virtual Reality for Reducing Opioid Use After Cardiac and Thoracic Surgery

PainVirtual RealityHeart Surgery+2 more
Filomena R B G Galas60 enrolled1 locationNCT07063394
Recruiting
Not Applicable

Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment

Chronic PainOpioid-use Disorder
Albert Einstein College of Medicine123 enrolled1 locationNCT05039554
Recruiting
Not Applicable

Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

Opioid UseCesarean Section Complications
Senthil Sadhasivam700 enrolled4 locationsNCT05380531
Recruiting

Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

Opioid Withdrawal
Spark Biomedical, Inc.20 enrolled2 locationsNCT06487533