Opioid Clinical Trials

1 recruiting

Frequently Asked Questions

Common questions about Opioid clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting
Phase 2

MDMA for Co-occurring PTSD and OUD After Childbirth

Stress Disorders, Post-TraumaticOpioid-use Disorder
University of New Mexico15 enrolled1 locationNCT05219175
Recruiting
Phase 2

Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder

Opioid-use DisorderOpioid Use Disorder, ModerateOpioid Use Disorder, Severe
T. John Winhusen, PhD310 enrolled10 locationsNCT06651177
Recruiting
Not Applicable

Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

Opioid UsePostoperative PainAnxiety Postoperative
Massachusetts General Hospital80 enrolled1 locationNCT04912531
Recruiting
Not Applicable

HIV, Equity, and Addiction Training (HEAT) Program

Substance Use DisordersOpioid-use DisorderHIV+1 more
University of Alabama at Birmingham30 enrolled1 locationNCT06370481
Recruiting
Phase 3

Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

Prostate CancerOpioid Consumption, PostoperativeMultimodal Analgesia+2 more
Brigham and Women's Hospital300 enrolled2 locationsNCT07427043
Recruiting
Not Applicable

Preoperative Opioid Tapering Before Spine Surgery

Opioid Consumption, PostoperativePain After SurgeryOpioid Dependency
Thomas Jefferson University45 enrolled1 locationNCT07221786
Recruiting
Not Applicable

Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement

Opioid UseCancer PainLiver Transplant+2 more
Jacques E. Chelly286 enrolled4 locationsNCT05506878
Recruiting
Not Applicable

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

Opioid-use DisorderPosttraumatic Stress Disorder (PTSD)
The City College of New York15 enrolled1 locationNCT06872164
Recruiting
Phase 4

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

Opioid UsePostoperative PainDepression+2 more
Texas Tech University Health Sciences Center90 enrolled2 locationsNCT06903819
Recruiting
Not Applicable

Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery

Colorectal, CancerNETsOpioid-free Anesthesia
Fudan University90 enrolled1 locationNCT07264556
Recruiting
Not Applicable

Integrated Treatment for Opioid Use Disorder and PTSD

Opioid-use DisorderPosttraumatic Stress Disorder (PTSD)
Medical University of South Carolina76 enrolled1 locationNCT06641115
Recruiting
Not Applicable

Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons

PregnancyOpioid-use Disorder
Medical University of South Carolina37 enrolled1 locationNCT06999811
Recruiting
Not Applicable

Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

Opioid UseHIV InfectionsSubstance Use Disorders+3 more
Johns Hopkins University360 enrolled2 locationsNCT06103370
Recruiting
Not Applicable

Low-Intensity Focused Ultrasound and the Complex Patient

Chronic PainOpioid-use DisorderAnxiety Disorder
Virginia Polytechnic Institute and State University25 enrolled1 locationNCT06297200
Recruiting
Phase 3

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

PainBone MetastasesOpioid Use+2 more
St. Louis University60 enrolled1 locationNCT03823534
Recruiting
Not Applicable

Mindfulness in Endometrial and Cervical Cancer

Cervical CancerEndometrial CancerOpioid Use+2 more
St. Louis University120 enrolled1 locationNCT04512144
Recruiting
Not Applicable

Expanding Medication-Assisted Therapies in Central Asia

Opioid-use Disorder
Yale University900 enrolled4 locationsNCT05579470
Recruiting
Phase 1

A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.

Multiple SclerosisOpioid DependenceAlcohol Dependence
Inventage Lab., Inc.40 enrolled1 locationNCT05620940
Recruiting
Not Applicable

Efficacy of Perioperative Opioid Sparing Techniques on Time to Initiation of Chemotherapy

Perioperative Opioid Sparing Techniques
University of Tennessee Graduate School of Medicine200 enrolled1 locationNCT07153614
Recruiting

Nudging to Promote the Use of Transcutaneous Electrical Nerve Stimulation for Postoperative Pain Relief

Acute Postoperative Pain in Urological SurgeryPain Management in Postoperative Care (Including Opioid-Sparing Approaches)
Pether Jildenstal500 enrolled5 locationsNCT06696430