Phase 4 Opioid Clinical Trials
27 recruitingPhase 4
What is a Phase 4 trial?
Phase 4 trials, also called post-marketing studies, are conducted after a treatment has been approved and is available to the public. They monitor long-term effectiveness and safety in a broader population.
Showing 1–20 of 27 trials
Recruiting
Phase 4
Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures
Opioid UseFractures, BoneTrauma
Henry Ford Health System75 enrolled1 locationNCT06113211
Recruiting
Phase 4
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Opioid UsePostoperative PainDepression+1 more
Texas Tech University Health Sciences Center90 enrolled2 locationsNCT06903819
Recruiting
Phase 4
Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery
Anesthesia, SpinalAnalgesics, Opioid
Medical University of Silesia120 enrolled3 locationsNCT06878014
Recruiting
Phase 4
Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia
PainAnalgesiaAbuse Opioids
Vanderbilt University Medical Center120 enrolled1 locationNCT05988710
Recruiting
Phase 4
Vending Machine Naloxone Distribution for Your Community (VENDY)
Harm ReductionOpioid OverdoseNaloxone
University of Colorado, Denver4,000 enrolled3 locationsNCT06429436
Recruiting
Phase 4
Opioid Use After Laparoscopic Salpingectomy
Opioid Use
Johns Hopkins University120 enrolled1 locationNCT06434233
Recruiting
Phase 4
Better Options for Chronic Cancer Pain
Chronic PainCancer SurvivorOpioid Dependence
VA Office of Research and Development294 enrolled2 locationsNCT06574009
Recruiting
Phase 4
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
Opioid UsePostoperative PainVaginal Hysterectomy+2 more
University of North Carolina, Chapel Hill56 enrolled1 locationNCT07213635
Recruiting
Phase 4
Young Houston Emergency Opioid Engagement System
Opioid UseSubstance Use DisordersOpioid-use Disorder+2 more
The University of Texas Health Science Center, Houston250 enrolled1 locationNCT04811014
Recruiting
Phase 4
Erector Spinae Block in Reducing Peri-operative Opioid Consumption in Total Abdominal Hystrectomy
Erector Spinae BlockOpioidEnhanced Recovery After Surgery (ERAS) Protocol
Kulsoom International Hospital60 enrolled1 locationNCT07178262
Recruiting
Phase 4
Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia
Pain ManagementPostoperative CareAnalgesic Drugs+3 more
Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology100 enrolled1 locationNCT07070050
Recruiting
Phase 4
Prophylactic Use of Naldemedine on Opioid-induced Nausea and Vomiting in Patients With Cancer: POSEIDON Study
Opioid-Induced Constipation (OIC)
International University of Health and Welfare120 enrolled1 locationNCT07038551
Recruiting
Phase 4
Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.
Opioid UsePain, PostoperativeMajor Surgery
Universidad de Antioquia120 enrolled1 locationNCT06774274
Recruiting
Phase 4
Intraoperative Autonomic Blockade for Laparoscopic Cholecystectomy
Opioid UseAnalgesiaVisceral Pain+1 more
Universidad Simón Bolívar60 enrolled2 locationsNCT06753500
Recruiting
Phase 4
Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair
Opioid UsePostoperative PainAnesthesia+5 more
University of Crete40 enrolled1 locationNCT04894864
Recruiting
Phase 4
Low-Dose Ketamine Infusion During Burn Wound Care
PainOpioidDissociation+1 more
University of Tennessee140 enrolled1 locationNCT06506565
Recruiting
Phase 4
Prevention of Opioid-induced Constipation in Patients With Advanced Cancer
Constipation, Opioid-Induced
Amsterdam UMC, location VUmc330 enrolled13 locationsNCT05216328
Recruiting
Phase 4
Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
Multimodal AnalgesiaOpioid Consumption
Medical University of Warsaw188 enrolled1 locationNCT06563349
Recruiting
Phase 4
Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.
AnesthesiaNociceptive PainOpioid Use, Unspecified
Ciusss de L'Est de l'Île de Montréal64 enrolled1 locationNCT06291363
Recruiting
Phase 4
IPACK on Early Pain Scores After ACL Reconstruction
Pain, PostoperativeAnterior Cruciate Ligament InjuriesAnalgesics, Opioid
Loyola University78 enrolled1 locationNCT05985629