Pre-diabetes Clinical Trials

43 recruitingLast updated: June 18, 2026

There are 43 actively recruiting pre-diabetes clinical trials across 17 countries. Studies span Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 1. Top locations include Chicago, Illinois, United States, Singapore, Singapore, Aurora, Colorado, United States. Updated daily from ClinicalTrials.gov.


Pre-diabetes Trials at a Glance

43 actively recruiting trials for pre-diabetes are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 26 trials, with the heaviest enrollment activity in Chicago, Singapore, and Aurora. Lead sponsors running pre-diabetes studies include Clinical Nutrition Research Center, Illinois Institute of Technology, Albert Einstein College of Medicine, and AdventHealth Translational Research Institute.

Browse pre-diabetes trials by phase

Treatments under study

About Pre-diabetes Clinical Trials

Looking for clinical trials for Pre-diabetes? There are currently 57 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pre-diabetes trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pre-diabetes clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting
Not Applicable

7-Ketolithocholic Acid in Prediabetes

Pre-diabetes
ICE S.p.A.100 enrolled8 locationsNCT07650123
Recruiting
Not Applicable

Sisters for Heart Health: A Community Health Worker Initiative for Improving Heart Health in Farmworker Women

ObesityHypertensionDiabetes+4 more
Emory University269 enrolled1 locationNCT07111026
Recruiting
Not Applicable

Milk for Diabetes Prevention

Lactose intoleranceDiabetes Mellitus, Type 2Pre-diabetes+2 more
Albert Einstein College of Medicine40 enrolled1 locationNCT06513026
Recruiting
Not Applicable

The GRoceries Aimed at Increasing Nutrition Study

Type 2 Diabetes Mellitus (T2DM)Type 2 DiabetesType 2 Diabetes (T2DM)+6 more
University of Pennsylvania216 enrolled1 locationNCT07167004
Recruiting
Not Applicable

OGTT at Home Using CGM vs at the Clinic

DiabetesPre-diabetes
Linkoeping University75 enrolled3 locationsNCT06862128
Recruiting
Not Applicable

Stand up for Your Health With a Sit-stand Desk

ObesityMetabolic SyndromeSedentary Behavior+1 more
Medical College of Wisconsin198 enrolled1 locationNCT05585190
Recruiting
Not Applicable

Comparing a Healthy Beef-Centric Diet to a Healthy U.S.-Style Diet on Metabolic Health Outcomes in Pre-Diabetic Adults

InflammationPre-diabetesMetabolic Syndrome (MetS)
National Cattlemen's Beef Association, a contractor to the Beef Checkoff56 enrolled1 locationNCT07269847
Recruiting
Phase 4

Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide

Diabetes Mellitus, Type 2DiabetesType 2 Diabetes+1 more
Stanford University104 enrolled2 locationsNCT06657209
Recruiting

Glycemic Metrics and Patterns in People With and Without Prediabetes

Pre-diabetes
Abbott Diabetes Care2,000 enrolled1 locationNCT06921902
Recruiting
Phase 4

The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

ObesityPre-diabetes
Philip Kern96 enrolled1 locationNCT05051436
Recruiting
Phase 2

Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health

Metabolic SyndromePre-diabetes
University of California, San Diego140 enrolled1 locationNCT07189234
Recruiting
Not Applicable

Lifestyle Patterns and Glycemic Control

Pre-diabetes
Columbia University34 enrolled1 locationNCT05224986
Recruiting
Not Applicable

Continuous Glucose Monitoring (CGM) in Prediabetes

Pre-diabetes
SingHealth Polyclinics76 enrolled2 locationsNCT07371546
Recruiting
Not Applicable

Preventing Diabetes: Impact of an EMR-Based Intervention for Enhanced Pre-Diabetes Management in Primary Care

Diabetes (DM)Pre-diabetes
Lynette Goh6,000 enrolled1 locationNCT07252700
Recruiting

INNODIA Family & Friends Early-Stage T1D Detection Protocol

Pre-diabetesType 1 Diabetes (T1D)
INNODIA iVZW30,000 enrolled5 locationsNCT07118098
Recruiting
Not Applicable

Mechanisms of Prediabetic States in Sleep Apnea

Sleep ApneaPre-diabetes
University of Chicago300 enrolled1 locationNCT04234217
Recruiting
Phase 1

Prevention of Progression of Prediabetes, Obesity and CV Risk

Cardiovascular DiseasesPre-diabetesWeight, Body
The University of Texas Health Science Center at San Antonio64 enrolled1 locationNCT06446531
Recruiting
Not Applicable

Mechanisms of Fatigability With Diabetes

Type 2 DiabetesPre-diabetes
University of Michigan80 enrolled1 locationNCT04442451
Recruiting
Not Applicable

Timing Exercise Training as Strategy to Improve Insulin Sensitivity and Substrate Metabolism in Men and Woman With Pre-diabetes

Overweight and ObesityPre-diabetes
Maastricht University Medical Center24 enrolled1 locationNCT06014684
Recruiting

UK Islet Autoantibody Registry

ScreeningPre-diabetesType 1 Diabetes (T1D)+1 more
University of Oxford350 enrolled1 locationNCT07125365