renal replacement therapy Clinical Trials

23 recruitingLast updated: June 20, 2026

There are 23 actively recruiting renal replacement therapy clinical trials across 37 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Toulouse, France, São Paulo, Brazil, Bordeaux, France. Updated daily from ClinicalTrials.gov.


renal replacement therapy Trials at a Glance

23 actively recruiting trials for renal replacement therapy are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 7 trials, with the heaviest enrollment activity in Toulouse, São Paulo, and Bordeaux. Lead sponsors running renal replacement therapy studies include Hospices Civils de Lyon, Centre Hospitalier de Valenciennes, and Centre Hospitalier Universitaire de Nīmes.

Browse renal replacement therapy trials by phase

Treatments under study

About renal replacement therapy Clinical Trials

Looking for clinical trials for renal replacement therapy? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new renal replacement therapy trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about renal replacement therapy clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 23 trials

Recruiting
Not Applicable

Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient

Continuous renal replacement therapyAcute Kidney InjuryIntensive Care Unit
Centre Hospitalier Universitaire de Nīmes80 enrolled1 locationNCT06369064
Recruiting
Not Applicable

Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)

TemperatureBlood PressureCardiac Arrest (CA)+9 more
Helsinki University Central Hospital3,500 enrolled52 locationsNCT07579390
Recruiting
Phase 3

Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT

Acute Kidney Injury (AKI)Regional Citrate Anticoagulation (RCA)Continuous Renal Replacement Therapy (CRRT)
Vantive Health LLC40 enrolled14 locationsNCT05399537
Recruiting
Phase 2

Comparison of Anticoagulant Effects of Different Doses of Nafamostat in Continuous Renal Replacement Therapy (CRRT) in the Intensive Care Unit (ICU)

Continuous Renal Replacement Therapy (CRRT)
Zhujiang Hospital92 enrolled1 locationNCT07469072
Recruiting
Not Applicable

Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy

Acute Kidney InjuryICU PatientsContinuous Renal Replacement Therapy (CRRT)+1 more
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau43 enrolled1 locationNCT07514650
Recruiting

Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America

renal replacement therapyAcute Kidney InjuryRenal Replacement Therapy for Acute Kidney Injury in ICU+3 more
University of Alabama at Birmingham1,000 enrolled15 locationsNCT07262320
Recruiting
Not Applicable

Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients

renal replacement therapyAcute Kidney InjuryVenoarterial Extracorporeal Membrane Oxygenation
Hospices Civils de Lyon158 enrolled12 locationsNCT06038162
Recruiting

Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy

renal replacement therapyCritically Ill
Hospices Civils de Lyon30 enrolled1 locationNCT06285162
Recruiting

Timing of Renal Replacement Therapy Initiation in Tumor Lysis Syndrome

Renal Replacement Therapy for Acute Kidney Injury in ICU
University Hospital, Bordeaux800 enrolled10 locationsNCT06889974
Recruiting
Not Applicable

Post-Filter Hematocrit

Continuous renal replacement therapyRenal FailureHemofilter Clotting
Gwyndolyn M. Radford20 enrolled1 locationNCT07293936
Recruiting
Phase 2

Effects of Variation of Sodium Dialysate in ICU

renal replacement therapyAcute Kidney Injury
University Hospital, Montpellier158 enrolled1 locationNCT03329313
Recruiting

Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions

Continuous renal replacement therapyRenal InjuryRegional Citrate Anticoagulation
Fujian Provincial Hospital30 enrolled1 locationNCT06021080
Recruiting

The Role of Renal Resistive Index (RI) in Predicting Acute Kidney Injury Progression in Intensive Care Clinic

Renal Replacement Therapy for Acute Kidney Injury in ICUAkut Kidney Injury
Gulhane Training and Research Hospital120 enrolled1 locationNCT06995222
Recruiting
Phase 4

Albumin To Enhance Recovery After Acute Kidney Injury

renal replacement therapyAcute Kidney InjuryCritical Illness+1 more
Ottawa Hospital Research Institute856 enrolled16 locationsNCT04705896
Recruiting

Filter Lifespan in Continuous Renal Replacement Therapy

Continuous renal replacement therapyInfectionsCritically Ill
University Hospital Muenster600 enrolled5 locationsNCT05450185
Recruiting
Not Applicable

The Cost-effectiveness of Artificial Intelligence Acute Kidney Injury Prediction Auxiliary Software (Acura AKI)

renal replacement therapyAcute Kidney InjuryIntensive Care
Huede Healthtech Co., Ltd.3,600 enrolled1 locationNCT06685367
Recruiting
Phase 2Phase 3

Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients

Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Jikei University School of Medicine400 enrolled9 locationsNCT06014801
Recruiting

Beta-Lactams Dosing In Pneumonia in ICU in Patients Treated by Continuous Renal Replacement Therapy: the BLIPIC Study

Continuous renal replacement therapyPneumoniaBeta-lactam+1 more
Centre Hospitalier de Valenciennes65 enrolled1 locationNCT03897582
Recruiting
Not Applicable

Aminoglycoside Administration in Septic Patients

renal replacement therapySepsisSeptic Shock+1 more
University of Thessaly50 enrolled1 locationNCT06226441
Recruiting

Utility of Non-invasive Cardiac Output Estimation in Patients Undergoing Continuous Renal Replacement Therapy and Haemodialysis

renal replacement therapy
Austin Health30 enrolled1 locationACTRN12623000711617