Sinusitis Clinical Trials

4 recruiting

Frequently Asked Questions

Common questions about Sinusitis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 61 trials

Recruiting
Phase 3

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Chronic Rhinosinusitis With Nasal Polyps
Sanofi210 enrolled121 locationsNCT06834347
Recruiting
Phase 3

A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Chronic Rhinosinusitis With Nasal Polyps
Sanofi210 enrolled108 locationsNCT06834360
Recruiting

ReAl-woRld Evaluation of tEzepelumab for Chronic rhinoSinusitis With Nasal Polyps in Russia

AsthmaChronic Rhinosinusitis With Nasal Polyps (CRSwNP)
AstraZeneca110 enrolled6 locationsNCT07399665
Recruiting
Not Applicable

Efficacy and Safety of Fully Resorbable Sinus Drug-eluting Stents in Patients With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps After Surgery: A Prospective, Randomized Controlled Trial

Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Tang-Du Hospital192 enrolled1 locationNCT07498374
Recruiting
Phase 3

A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Eli Lilly and Company510 enrolled190 locationsNCT06338995
Recruiting
Phase 3

A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab

Chronic Rhinosinusitis With Nasal Polyps
AstraZeneca180 enrolled44 locationsNCT06706817
Recruiting
Phase 3

Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps

Chronic Rhinosinusitis Without Nasal Polyps
Optinose US Inc.84 enrolled21 locationsNCT06850805
Recruiting

Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis

Rhinosinusitis
University of Alabama at Birmingham20 enrolled1 locationNCT02038166
Recruiting
Phase 3

The Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in Adult Patients

RhinosinusitisRhinosinusitis Acute
Materia Medica Holding552 enrolled44 locationsNCT06901297
Recruiting
Phase 2Phase 3

Using Navigation to Improve Accuracy of Maxillary Balloon Sinusotomy

Chronic Maxillary Rhinosinusitis
Cedars-Sinai Medical Center50 enrolled1 locationNCT06567821
Recruiting
Phase 2

Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

Chronic Rhinosinusitis With Nasal Polyps
Sanofi64 enrolled20 locationsNCT06914908
Recruiting
Phase 4

Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis

Acute SinusitisSinus Infection
Daniel Merenstein3,720 enrolled7 locationsNCT06076304
Recruiting

Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis

Chronic Rhinosinusitis With Nasal Polyps
Montefiore Medical Center60 enrolled1 locationNCT05246267
Recruiting
Not Applicable

Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care

AnginaAcute BronchiolitisAcute Bronchitis+8 more
University Hospital, Caen4,500 enrolled1 locationNCT07359287
Recruiting
Early Phase 1

The Role of IL5 in Epithelial Cell Integrity

Chronic Rhinosinusitis With Nasal PolypsChronic Rhinosinusitis (Diagnosis)
Johns Hopkins University8 enrolled2 locationsNCT05895929
Recruiting
Not Applicable

In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps

SinusitisNasal Polyps
Ottawa Hospital Research Institute140 enrolled4 locationsNCT02975310
Recruiting
Not Applicable

Real-Time Diagnosis of Eosinophilic Nasal Polyps Using High-Sensitivity Spectroscopy

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
The Affiliated Hospital of Qingdao University353 enrolled1 locationNCT07125586
Recruiting
Phase 3

Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

Chronic Rhinosinusitis (CRS)Cystic Fibrosis (CF)
Indiana University64 enrolled1 locationNCT06996951
Recruiting
Not Applicable

Efficacy of Lavender Aromatherapy on Anxiety and Pain Reduction During Awake Otolaryngologic Procedures

Thyroid NodulesInferior Turbinate HypertrophyChronic Rhinosinusitis (CRS)+2 more
Cedars-Sinai Medical Center184 enrolled1 locationNCT07299474
Recruiting
Phase 3

Clinical Trial of TQC2731 Injection in Patients With Chronic Sinusitis and Nasal Polyps

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.246 enrolled60 locationsNCT07107256