Phase 1 TEN Clinical Trials
117 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 117 trials
Recruiting
Phase 1
Efficacy and Safety of Autologous Peptide-induced Active Immunity in AML Maintenance Therapy
Acute Myeloid LeukemiaMaintenance TherapyPersonalized Active Immunotherapy
Fujian Medical University Union Hospital90 enrolled1 locationNCT07551037
Recruiting
Phase 1
Study of Intravenous ZMA001 in Healthy Subjects
Pulmonary Arterial Hypertension PAH
National Heart, Lung, and Blood Institute (NHLBI)96 enrolled1 locationNCT05967299
Recruiting
Phase 1Phase 2
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Healthy Volunteers, Pulmonary Arterial Hypertension
Novartis Pharmaceuticals232 enrolled85 locationsNCT06649110
Recruiting
Phase 1Phase 2
A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)
Small Cell Lung Cancer Extensive Stage
Merck Sharp & Dohme LLC170 enrolled15 locationsNCT07227597
Recruiting
Phase 1
Achilles Tendinopathy Embolization
Achilles Tendinopathy (AT)
Joint & Vascular Institute10 enrolled1 locationNCT07477860
Recruiting
Phase 1Phase 2
Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer
Stage IV Lung Cancer AJCC v8Extensive Stage Lung Small Cell Carcinoma
National Cancer Institute (NCI)45 enrolled43 locationsNCT06287775
Recruiting
Phase 1
A Study of LY3971297 in Healthy Participants
ObesityHypertensionHealthy
Eli Lilly and Company225 enrolled7 locationsNCT06148272
Recruiting
Phase 1Phase 2
Feasibility of Semaglutide in Advanced Lung Disease
ObesityChronic Obstructive Pulmonary DiseaseInterstitial Lung Disease+2 more
University of Pennsylvania8 enrolled1 locationNCT05746039
Recruiting
Phase 1
A Study to Test How BI 3031185 is Tolerated by People With Borderline Personality Disorder or Attention-deficit/Hyperactivity Disorder
Attention Deficit Hyperactivity DisorderBorderline Personality Disorder
Boehringer Ingelheim96 enrolled12 locationsNCT07001475
Recruiting
Phase 1
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
Hypertension in Pregnancy
University of Alabama at Birmingham74 enrolled1 locationNCT05989581
Recruiting
Phase 1Phase 2
Vyxeos for Re-induction Treatment of Acute Myeloid Leukemia Patients With Persistent Disease After Induction
Refractory Acute Myeloid LeukemiaBlasts More Than 5 Percent of Bone Marrow Nucleated CellsPersistent Disease
Ohio State University Comprehensive Cancer Center28 enrolled2 locationsNCT04049539
Recruiting
Phase 1
Safety and Efficacy of SC101 Via Perirenal Fat Injection for Resistant Hypertension in Patients With Moderate to Severe Chronic Kidney Disease
Resistant Arterial HypertensionChronic Kidney Disease (Stage 3-4)
The First Affiliated Hospital with Nanjing Medical University3 enrolled1 locationNCT07483372
Recruiting
Phase 1
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
Lung TransplantPulmonary Hypertension
Mayo Clinic4 enrolled1 locationNCT06770023
Recruiting
Phase 1
A Study of Valemetostat in Combination With Atezolizumab in People With Lung Cancer
Extensive-stage Small-cell Lung Cancer
Memorial Sloan Kettering Cancer Center24 enrolled7 locationsNCT06807632
Recruiting
Phase 1Phase 2
EUS Guided Portal-systemic Pressure Gradient Measurement
CirrhosisPortal Hypertension
Chinese University of Hong Kong30 enrolled1 locationNCT04633356
Recruiting
Phase 1
A Study on the Efficacy and Safety of Empagliflozin in the Treatment of Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension
China National Center for Cardiovascular Diseases72 enrolled1 locationNCT06554301
Recruiting
Phase 1
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in Patients With Advanced Solid Tumor
NeoplasmsTenosynovial Giant Cell Tumor
Abbisko Therapeutics Co, Ltd276 enrolled17 locationsNCT04192344
Recruiting
Phase 1Phase 2
Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma
Colorectal Cancer (CRC)Metastatic Colorectal Carcinoma (mCRC)Adenomatous Polyposis Coli (APC) Gene Mutation+1 more
HonorHealth Research Institute126 enrolled1 locationNCT07463599
Recruiting
Phase 1
Preliminary Human Trials of F230 Tablets
Pulmonary Hypertension
Beijing Continent Pharmaceutical Co, Ltd.136 enrolled1 locationNCT06899815
Recruiting
Phase 1
Study of KK3910 in Healthy Volunteers and Patients With Essential Hypertension
Healthy Volunteers Essential Hypertension
Kyowa Kirin Co., Ltd.160 enrolled3 locationsNCT06823947