Phase 1 TEN Clinical Trials
140 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 140 trials
Recruiting
Phase 1
A Study of LY3971297 in Healthy Participants
ObesityHypertensionHealthy
Eli Lilly and Company225 enrolled7 locationsNCT06148272
Recruiting
Phase 1Phase 2
A Study to Evaluate DJI136, a DLL3-targeted CAR-T Therapy
Extensive-stage Small Cell Lung Cancer (ES-SCLC)
Novartis Pharmaceuticals80 enrolled3 locationsNCT07564401
Recruiting
Phase 1
Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies and HER2 Negative Breast Cancer
PTEN-Altered Advanced Solid Tumors and HER2 Negative Breast Cancer
Deborah Doroshow23 enrolled1 locationNCT04997993
Recruiting
Phase 1Phase 2
A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)
Small Cell Lung Cancer Extensive Stage
Merck Sharp & Dohme LLC170 enrolled31 locationsNCT07227597
Recruiting
Phase 1Phase 2
Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer
Stage IV Lung Cancer AJCC v8Extensive Stage Lung Small Cell Carcinoma
National Cancer Institute (NCI)45 enrolled43 locationsNCT06287775
Recruiting
Phase 1Phase 2
Post-operative Urinary Retention (POUR) Following Thoracic Surgery
Urinary Retention
Hackensack Meridian Health127 enrolled1 locationNCT03609580
Recruiting
Phase 1
A Study of Valemetostat in Combination With Atezolizumab in People With Lung Cancer
Extensive-stage Small-cell Lung Cancer
Memorial Sloan Kettering Cancer Center24 enrolled7 locationsNCT06807632
Recruiting
Phase 1
Study of Intravenous ZMA001 in Healthy Subjects
Pulmonary Arterial Hypertension PAH
National Heart, Lung, and Blood Institute (NHLBI)96 enrolled1 locationNCT05967299
Recruiting
Phase 1
Managing Chronic Tendon Pain by Metformin
Chronic PainAchilles tendinopathyTendinopathy
James Wang40 enrolled1 locationNCT06100822
Recruiting
Phase 1Phase 2
Quaratusugene Ozeplasmid (Reqorsa) and Atezolizumab Maintenance Therapy in ES-SCLC Patients
Small Cell Lung Cancer Extensive Stage
Genprex, Inc.62 enrolled17 locationsNCT05703971
Recruiting
Phase 1
A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)
Extensive-stage Small-cell Lung Cancer
Amgen380 enrolled19 locationsNCT07037758
Recruiting
Phase 1Phase 2
Dexamethasone for Ureteral STent Symptoms (DUSTS)
Ureteral Stent-Related Symptom
The Methodist Hospital Research Institute70 enrolled1 locationNCT06930690
Recruiting
Phase 1
Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)
Extensive-stage Small-cell Lung Cancer
Amgen220 enrolled31 locationsNCT06598306
Recruiting
Phase 1Phase 2
Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease
Post Operative PainUrolithiasisStent Complication+1 more
University of Texas Southwestern Medical Center80 enrolled1 locationNCT06158620
Recruiting
Phase 1
A Study to Test How BI 3031185 is Tolerated by People With Borderline Personality Disorder or Attention-deficit/Hyperactivity Disorder
Attention Deficit Hyperactivity DisorderBorderline Personality Disorder
Boehringer Ingelheim96 enrolled9 locationsNCT07001475
Recruiting
Phase 1
Metabolic Effects of Angiotensin-(1-7)
ObesityInsulin ResistanceHypertension+1 more
Vanderbilt University26 enrolled1 locationNCT02646475
Recruiting
Phase 1Phase 2
A Phase Ⅰb/Ⅱa Clinical Study of IMC-003 Injection for the Treatment of Pulmonary Arterial Hypertension Receiving Background Therapy.
Pulmonary Arterial Hypertension PAH
ImmuneCare Biopharmaceuticals (Shanghai) Co., Ltd.120 enrolled32 locationsNCT07593027
Recruiting
Phase 1Phase 2
Cannabigerol Oil for Adolescents With ADHD (CAN-ADHD)
Attention Deficit Hyperactivity Disorder (ADHD)
Universidade do Sul de Santa Catarina60 enrolled1 locationNCT07592390
Recruiting
Phase 1Phase 2
Concurrent Neoadjuvant Chemoradiotherapy Plus Durvalumab (MEDI4736) in Resectable Stage III NSCLC
Potentially Resectable Stage II/IIIa NSCLC
Yonsei University39 enrolled1 locationNCT03694236
Recruiting
Phase 1
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
AsthmaCOPDCystic Fibrosis+4 more
Mario Castro, MD, MPH260 enrolled1 locationNCT04624490