Tongue Clinical Trials

22 recruitingLast updated: June 20, 2026

There are 22 actively recruiting tongue clinical trials across 14 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3. Top locations include New York, New York, United States, Middletown, New Jersey, United States, Commack, New York, United States. Updated daily from ClinicalTrials.gov.


Tongue Trials at a Glance

22 actively recruiting trials for tongue are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in New York, Middletown, and Commack. Lead sponsors running tongue studies include Memorial Sloan Kettering Cancer Center, Centre Hospitalier Universitaire, Amiens, and Cairo University.

Browse tongue trials by phase

Treatments under study

About Tongue Clinical Trials

Looking for clinical trials for Tongue? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Tongue trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Tongue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 22 trials

Recruiting

Spectroscopic Analysis of Tongue Tumor Samples.

Squamous Cell CarcinomaOral CavityMass Spectroscopy+3 more
Centre Hospitalier Universitaire, Amiens33 enrolled1 locationNCT05104619
Recruiting
Phase 1

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas

Esophageal Squamous Cell CarcinomaCutaneous Squamous Cell CancerBladder Cancer+8 more
EvolveImmune United, Inc160 enrolled10 locationsNCT07217171
Recruiting
Phase 2

A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma

Oral Tongue Squamous Cell Carcinoma
Memorial Sloan Kettering Cancer Center24 enrolled7 locationsNCT06485778
Recruiting
Not Applicable

Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial

Oral CancerTongue CancerSquamous Cell Carcinoma of the Oral Cavity or Oropharynx
Tobias Todsen150 enrolled7 locationsNCT07203911
Recruiting
Not Applicable

Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue

Oral CancerTongue NeoplasmsTongue Cancer
University of Michigan40 enrolled1 locationNCT02584270
Recruiting
Phase 2Phase 3

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Tongue Squamous Cell CarcinomaOral Cavity Squamous Cell CarcinomaStage I Lip and Oral Cavity Cancer AJCC v8+9 more
NRG Oncology686 enrolled106 locationsNCT04333537
Recruiting
Not Applicable

Healing Efficacy of Diode Laser in Lingual Frenectomy

AnkyloglossiaTongue-tie
University of Medicine and Pharmacy at Ho Chi Minh City53 enrolled2 locationsNCT07557875
Recruiting
Not Applicable

Orofacial Muscle Pressure and Maxillary Transverse Development

Maxillary Transversal Deficiency (Maxillary Constriction) and Perioral Muscle Pressures (Tongue, Lip, and Cheek)
Yuzuncu Yil University40 enrolled1 locationNCT07552441
Recruiting
Not Applicable

Treatment De-Escalation for Favorable Prognosis Human Papilloma Virus (HPV) or p16-Positive Oropharyngeal Cancer Receiving Definitive Radiotherapy

HPVTonsil CancerOropharyngeal Cancers+1 more
Georgetown University30 enrolled2 locationsNCT06902623
Recruiting
Phase 2

Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

Head and Neck CarcinomaOral Cavity CarcinomaMalignant Parotid Gland Neoplasm+4 more
M.D. Anderson Cancer Center119 enrolled7 locationsNCT04870762
Recruiting
Not Applicable

Force Sensor Study

Tongue injuryPost Operative PainLaryngeal Disease
University of California, San Francisco100 enrolled1 locationNCT07434583
Recruiting
Not Applicable

The Additional Effect of Tongue Scraping on Halitosis Parameters in Initial Periodontal Therapy

HalitosisPeriodontitisTongue Condition
Universitaire Ziekenhuizen KU Leuven39 enrolled1 locationNCT06091228
Recruiting

Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

Facial PalsyCongenital Fibrosis of Extraocular MusclesDuane Retraction Syndrome+23 more
Boston Children's Hospital20,000 enrolled1 locationNCT03059420
Recruiting
Not Applicable

Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck

Tongue CancerRecurrent Adenoid Cystic Carcinoma of the Oral CavityRecurrent Mucoepidermoid Carcinoma of the Oral Cavity+48 more
Ohio State University Comprehensive Cancer Center600 enrolled1 locationNCT01473784
Recruiting
Not Applicable

Postoperative Radiotherapy for Early-stage Oral Tongue Squamous Cell Carcinoma Patients With Risk Factors: a Prospective, Multicenter, Randomized Controlled, Open-labelled Trial

Oral Tongue Squamous Cell Carcinoma
Second Affiliated Hospital, School of Medicine, Zhejiang University190 enrolled28 locationsNCT07402525
Recruiting
Not Applicable

A Study of Tongue Strength and Endurance Using the Iowa Oral Performance Instrument (IOPI) Tongue Strength Trainer in People With Oral Tongue Cance

Tongue Cancer
Memorial Sloan Kettering Cancer Center60 enrolled7 locationsNCT07124520
Recruiting

Development of Novel Gastric Cancer Screening and Diagnosis Technologies Using Tongue Imaging and Study of Tongue Image Changes Mechanisms

Gastric CancerDiagnosisTongue Images
Zhejiang Cancer Hospital100,000 enrolled1 locationNCT06078930
Recruiting

Arabic PRO Measures for Head and Neck Cancer Radiotherapy.

Head and Neck CancerHead and Neck Squamous Cell CarcinomaHead and Neck Neoplasms+5 more
King Saud University125 enrolled1 locationNCT06662929
Recruiting
Not Applicable

Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue

Squamous Cell CarcinomaTranscriptomicsProton Magnetic Resonance Spectroscopy+1 more
Centre Hospitalier Universitaire, Amiens60 enrolled1 locationNCT06450080
Recruiting
Not Applicable

Assessment of the Effect of Tumor Thickness and Site on Level IV Cervical Lymph Nodes in Squamous Cell Carcinoma of the Tongue and Floor of the Mouth: A Case Series Study

Tongue Neoplasms
Cairo University20 enrolled1 locationNCT06169605