RecruitingNCT06007404

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

The Role of Circulating Meta-Inflammatory Monocytes in Adolescent Insulin Resistance


Sponsor

University of Michigan

Enrollment

175 participants

Start Date

Sep 6, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.


Eligibility

Min Age: 14 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how metabolism and inflammation in teenagers relate to diabetes risk — looking at adolescents with normal weight, overweight, obesity, pre-diabetes, or type 2 diabetes to understand early warning signs. **You may be eligible if:** - You are between 14 and 18 years old - You are at Tanner stage 4 or 5 (late puberty or fully mature) - You fall into one of these groups: normal weight, overweight, obese, pre-diabetes, or type 2 diabetes **You may NOT be eligible if:** - You are currently pregnant - You take medications that affect blood sugar (such as immunosuppressants, cancer drugs, or high-dose steroids), unless prescribed for type 2 diabetes - You have an autoimmune disease, cancer, or a cognitive disability that would prevent you from following study instructions - You are allergic or intolerant to milk, soy, or palm oil Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

University of Michigan

Ann Arbor, Michigan, United States

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NCT06007404


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