End Stage Liver Disease Clinical Trials

17 recruitingLast updated: June 18, 2026

There are 17 actively recruiting end stage liver disease clinical trials across 6 countries. Studies span Not Applicable, Phase 1, Phase 2. Top locations include Chicago, Illinois, United States, Boston, Massachusetts, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


End Stage Liver Disease Trials at a Glance

17 actively recruiting trials for end stage liver disease are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Chicago, Boston, and New York. Lead sponsors running end stage liver disease studies include Massachusetts General Hospital, Mayo Clinic, and University of Pennsylvania.

Browse end stage liver disease trials by phase

Treatments under study

About End Stage Liver Disease Clinical Trials

Looking for clinical trials for End Stage Liver Disease? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new End Stage Liver Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about End Stage Liver Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting
Not Applicable

Effect of Preoperative Oral Carbohydrate Loading on Postoperative Outcomes in Liver Transplant Patients

Liver TransplantLiver Transplant SurgeryLiver Transplantation+1 more
Medical University of Warsaw434 enrolled1 locationNCT07519057
Recruiting
Not Applicable

Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease

Physical InactivityCirrhosis, LiverMuscle Loss+2 more
University of Pennsylvania110 enrolled2 locationsNCT06136221
Recruiting
Not Applicable

Nutrition and Exercise Prehabilitation in Patients Awaiting Liver Transplantation

SarcopeniaLiver CirrhosisFrailty+3 more
Kalliopi Anna Poulia90 enrolled2 locationsNCT07561138
Recruiting

Disparities Among Liver Transplant Patients

End Stage Liver Disease
Mayo Clinic100 enrolled1 locationNCT05981196
Recruiting
Phase 1Phase 2

Immune Tolerance Induction After Liver Transplantation

Liver TransplantationEnd Stage Liver DiseaseImmune Tolerance+6 more
University of California, Los Angeles12 enrolled1 locationNCT07269041
Recruiting

Multidimensional Frailty Assessment and Post-Transplant Outcomes in Liver Transplant Candidates

CirrhosisLiver TransplantationEnd Stage Liver Disease
Izmir Bakircay University60 enrolled1 locationNCT07414095
Recruiting
Phase 1

A Study of SIPLIZUMAB in AILD and LT Patients

Autoimmune HepatitisCirrhosis, LiverPrimary Sclerosing Cholangitis+3 more
Elizabeth C. Verna8 enrolled1 locationNCT06455280
Recruiting
Not Applicable

Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors

End Stage Renal DiseaseEnd Stage Liver Disease
Johns Hopkins University1,000 enrolled6 locationsNCT03803423
Recruiting
Not Applicable

Adverse Outcomes and Mortality in Liver Transplant

SarcopeniaCirrhosisEnd Stage Liver Disease+1 more
Mayo Clinic100 enrolled1 locationNCT05477277
Recruiting
Phase 2

Allogenic Hepatocyte Transplantation Into Periduodenal Lymph Nodes

End Stage Liver Disease
LyGenesis, Inc.12 enrolled2 locationsNCT04496479
Recruiting
Not Applicable

HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

CirrhosisLiver CirrhosisEnd Stage Liver Disease+1 more
Massachusetts General Hospital30 enrolled2 locationsNCT05205954
Recruiting
Not Applicable

LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease

CirrhosisCirrhosis, LiverEnd Stage Liver Disease+2 more
Massachusetts General Hospital200 enrolled1 locationNCT05998330
Recruiting

Functional Assessment in Liver Transplantation

End Stage Liver Disease
University of California, San Francisco5,000 enrolled12 locationsNCT03228290
Recruiting

SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury

Liver DysfunctionJaundicePortal Hypertension+1 more
Nanfang Hospital, Southern Medical University411 enrolled1 locationNCT06173947
Recruiting
Not Applicable

Technology Enabled Strategies to Promote Treatment Adherence in Liver Transplant

CirrhosisLiver Transplant; ComplicationsEnd Stage Liver Disease+1 more
University of Pennsylvania360 enrolled3 locationsNCT05260268
Recruiting

Vienna Hypothermic Oxygenated Machine Perfusion Study

Hepatocellular CarcinomaEnd Stage Liver Disease
Medical University of Vienna500 enrolled1 locationNCT06418165
Recruiting

Real World Study of End-stage Liver Disease in China

ComplicationEnd Stage Liver Disease
Huashan Hospital10,000 enrolled1 locationNCT04037995