aortic regurgitation Clinical Trials

17 recruitingLast updated: May 11, 2026

There are 17 actively recruiting aortic regurgitation clinical trials across 17 countries. Studies span Not Applicable, Phase 4. Top locations include Shanghai, Shanghai Municipality, China, New York, New York, United States, Detroit, Michigan, United States. Updated daily from ClinicalTrials.gov.


aortic regurgitation Trials at a Glance

17 actively recruiting trials for aortic regurgitation are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Shanghai, New York, and Detroit. Lead sponsors running aortic regurgitation studies include JenaValve Technology, Inc., The Cleveland Clinic, and Chinese University of Hong Kong.

Browse aortic regurgitation trials by phase

Treatments under study

About aortic regurgitation Clinical Trials

Looking for clinical trials for aortic regurgitation? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new aortic regurgitation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about aortic regurgitation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting

DELINEATE-Prospective

Valvular Heart DiseaseValve Disease, AorticAortic Stenosis+3 more
Columbia University50 enrolled1 locationNCT07197736
Recruiting
Not Applicable

ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

Aortic Valve InsufficiencyAortic Insufficiencyaortic regurgitation
JenaValve Technology, Inc.1,016 enrolled21 locationsNCT06608823
Recruiting
Not Applicable

The JenaValve ALIGN-AR LVAD Registry

Aortic Valve DiseaseLeft Ventricular DysfunctionAortic Valve Insufficiency+2 more
JenaValve Technology, Inc.50 enrolled15 locationsNCT06594705
Recruiting
Not Applicable

Artificial Intelligence in Aortic Regurgitation

Aortic Regurgitation Disease
Chinese University of Hong Kong540 enrolled1 locationNCT07486271
Recruiting
Not Applicable

ART Trial: Transcatheter J-VALVE Versus Surgery for Aortic Regurgitation Therapy

Aortic Valve InsufficiencyAortic Insufficiencyaortic regurgitation
Second Affiliated Hospital, School of Medicine, Zhejiang University1,250 enrolled12 locationsNCT07453407
Recruiting
Phase 4

TRanscAtheter TreatMent of PurE Aortic Regurgitation With VitaFlow Liberty System

AORTIC VALVE DISEASESTranscatheter Aortic Valve Replacement (TAVR)aortic regurgitation
Ruijin Hospital120 enrolled4 locationsNCT06818084
Recruiting

Comparative Imaging Assessment of Valvular Heart Disease

Valve Heart DiseaseAortic Stenosisaortic regurgitation
The Cleveland Clinic200 enrolled1 locationNCT04126018
Recruiting

Noninvasive Real-Time Arterial Waveform Monitoring for Cardiovascular Disease Assessment

Healthy SubjectsAortic Stenosis DiseaseAortic Regurgitation Disease
Anhui Provincial Cancer Hospital15 enrolled1 locationNCT07350629
Recruiting

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

Mitral RegurgitationAortic Stenosisaortic regurgitation
The Cleveland Clinic200 enrolled1 locationNCT06780241
Recruiting

The ARTEMIS Data Collection Study

Aortic Regurgitation Disease
IRCCS Policlinico S. Donato75 enrolled1 locationNCT07075861
Recruiting
Not Applicable

Towards a More Standardized Bicuspid Aortic Valve Repair: Rationale and Design of CONTOUR Trial - a Randomized Trial

Aortic Regurgitation DiseaseBicuspid Aortic Valve (BAV)
University Hospital Augsburg100 enrolled4 locationsNCT06869954
Recruiting
Phase 4

Effect of Losartan on the Neurohumoral Axis and Ventricular Remodeling of Patients With Severe Aortic Regurgitation Undergoing Valve Surgery.

Heart Valve DiseasesHeart Failure, CongestiveLeft Ventricle Remodeling+2 more
Vitor Emer Egypto Rosa60 enrolled1 locationNCT07099859
Recruiting
Not Applicable

Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve

Mitral RegurgitationAORTIC VALVE DISEASESAortic Stenosis+3 more
Mitrassist Lifesciences Limited Co., Ltd.10 enrolled1 locationNCT07097740
Recruiting

Impact of Anesthesia, Positive Pressure Ventilation and Modality of Imaging on the Echocardiographic Assessment of the Severity of Aortic Regurgitation

Aortic Regurgitation DiseaseAortic Insufficiency
University of Liege100 enrolled1 locationNCT06835946
Recruiting
Not Applicable

Valvular Assessment of New Generation Aortic Replacement Devices

Aortic Regurgitation DiseaseAortic Valve CalcificationBicuspid Aortic Valve Disease
Instituto Dante Pazzanese de Cardiologia200 enrolled1 locationNCT06688448
Recruiting
Not Applicable

Safety and Effectiveness of TaurusTrio™ Heart Valve System in Patients With Severe Aortic Regurgitation (AR)

aortic regurgitation
Peijia Medical Technology (Suzhou) Co., Ltd.116 enrolled19 locationsNCT06101888
Recruiting

European Multicentre Registry of Percutaneous Paravalvular Leak Closure

OutcomesQuality of LifeCardiac Valve Disease+3 more
Centre Chirurgical Marie Lannelongue400 enrolled33 locationsNCT05506293