Phase 1 Arthritis Clinical Trials
100 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 100 trials
Recruiting
Phase 1
An Ascending Dose Study of PIT565 in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
Novartis Pharmaceuticals57 enrolled14 locationsNCT07029555
Recruiting
Phase 1
A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab)
Hidradenitis SuppurativaPsoriatic ArthritisAxial Spondyloarthritis+1 more
UCB Biopharma SRL20 enrolled12 locationsNCT06888193
Recruiting
Phase 1
A Study of AZD0120 in Autoimmune Diseases
Rheumatoid ArthritisIdiopathic Inflammatory MyopathiesSystemic Sclerosis
AstraZeneca27 enrolled18 locationsNCT07295847
Recruiting
Phase 1
Efficacy and Safety of HN2301 in Autoimmune Diseases（AIDs）
Rheumatoid ArthritisSclerodermaSystemic Lupus Erythematosus
Shenzhen MagicRNA Biotechnology Co., Ltd30 enrolled1 locationNCT06801119
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
Rheumatoid ArthritisSystemic Lupus ErythematosusIdiopathic Inflammatory Myopathies
AstraZeneca72 enrolled35 locationsNCT06916806
Recruiting
Phase 1
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
Psoriatic ArthritisAxial Spondyloarthritis
UCB Biopharma SRL392 enrolled42 locationsNCT07290036
Recruiting
Phase 1
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmRheumatoid Arthritis+11 more
National Cancer Institute (NCI)300 enrolled52 locationsNCT03816345
Recruiting
Phase 1
A Study of LY4298445 in Healthy Participants and Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
Rheumatoid ArthritisHealthySystemic Lupus Erythematosus
Eli Lilly and Company63 enrolled7 locationsNCT07276958
Recruiting
Phase 1
A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis
HealthyRheumatoid Arthritis (RA)
Eli Lilly and Company134 enrolled9 locationsNCT07258849
Recruiting
Phase 1
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
Rheumatoid Arthritis
Sonoma Biotherapeutics, Inc.24 enrolled8 locationsNCT06201416
Recruiting
Phase 1Phase 2
CBD for Pain Following Orthopedic Shoulder Surgery
Shoulder Osteoarthritis
The Methodist Hospital Research Institute80 enrolled1 locationNCT06381791
Recruiting
Phase 1Phase 2
EAST-1 (ERAP-inhibition in Axial Spondyloarthritis Trial - 1)
Axial Spondyloarthritis (AxSpA)
Grey Wolf Therapeutics141 enrolled14 locationsNCT07047703
Recruiting
Phase 1Phase 2
Controlling Hyperactive Immunity With Long-lived Lymphocytes
Rheumatoid Arthritis (RA)Autoimmune Rheumatologic DiseaseDiffuse Cutaneous Systemic Sclerosis+1 more
Quell Therapeutics Limited16 enrolled6 locationsNCT07473154
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
Bristol-Myers Squibb46 enrolled9 locationsNCT07171983
Recruiting
Phase 1
A Phase 1b Open-label Study to Evaluate Safety of Plamotamab in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
Xencor, Inc.68 enrolled3 locationsNCT07230353
Recruiting
Phase 1
A Study to Assess the Safety and Tolerability of SR-878 in Patients With Rheumatoid Arthritis
Rheumatoid Arthritis
SciRhom GmbH27 enrolled4 locationsNCT07433335
Recruiting
Phase 1
A Clinical Study of MK-1045 in People With Lupus or Rheumatoid Arthritis (MK-1045-004)
Rheumatoid ArthritisSystemic Lupus Erythematosus
Merck Sharp & Dohme LLC21 enrolled4 locationsNCT07363590
Recruiting
Phase 1
A Study of Intravenous CPTX2309 in Healthy Participants and Participants With Moderate to Severe Rheumatoid Arthritis (RA) or Systemic Lupus Erythematosus (SLE)
Rheumatoid ArthritisHealthy VolunteersSystemic Lupus Erythematosus
Capstan Therapeutics64 enrolled1 locationNCT06917742
Recruiting
Phase 1Phase 2
A Study to Assess Safety, Cellular Kinetics and Exploratory Efficacy of Rapcabtagene Autoleucel in Rheumatoid Arthritis and Sjogren's Disease
Rheumatoid Arthritis (RA) and Sjögren's Disease (SjD)
Novartis Pharmaceuticals27 enrolled11 locationsNCT07048197
Recruiting
Phase 1
Study of LFD-200 in Healthy Adults and Adults With Moderate to Severe Rheumatoid Arthritis
Rheumatoid Arthritis
Lifordi Immunotherapeutics, Inc.176 enrolled6 locationsNCT07207954