Phase 1 Cardiovascular Clinical Trials
20 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 20 trials
Recruiting
Phase 1
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
Cardiovascular Disease
National Heart, Lung, and Blood Institute (NHLBI)64 enrolled1 locationNCT04216342
Recruiting
Phase 1
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
HypercholesterolaemiaMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG90 enrolled18 locationsNCT07491172
Recruiting
Phase 1Phase 2
TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD
Endothelial DysfunctionAtherosclerotic Cardiovascular Diseases
Hudson Biotech80 enrolled1 locationNCT07487363
Recruiting
Phase 1Phase 2
Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases
TumorCardiovascular DiseasesPulmonary Fibrosis+3 more
Peking Union Medical College Hospital30 enrolled1 locationNCT07464132
Not Yet Recruiting
Phase 1
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Smartech Topical Aspirin Gel Formulation Following Multiple Applications in Healthy Adult Volunteers Compared to Oral Aspirin
Cardiovascular
Smartech Topical AU Pty Ltd38 enrolled1 locationACTRN12626000288325
Recruiting
Phase 1Phase 2
Clinical Application of Al18F-NOTA-FAPI-04 PET/CT or PET/MRI Imaging in Malignant Tumor,Cardiovascular or Immune Disease
Malignant TumorHyperthyroidism, AutoimmuneCardiovascular Abnormalities
Peking Union Medical College Hospital600 enrolled1 locationNCT07400224
Recruiting
Phase 1
Fish Oil, Metformin and Heart Health in PCOS
Cardiovascular DiseasePCOSAtherosclerotic Plaque+2 more
University of Alberta146 enrolled3 locationsNCT06424860
Recruiting
Phase 1
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Cardiovascular DiseasesEndothelial DysfunctionType 1 Diabetes+2 more
Kalie Tommerdahl60 enrolled2 locationsNCT05065372
Recruiting
Phase 1Phase 2
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
Cardiovascular DiseasesHypertension
University of Kansas Medical Center23 enrolled1 locationNCT04715022
Recruiting
Phase 1
Metabolic Effects of Angiotensin-(1-7)
ObesityInsulin ResistanceHypertension+1 more
Vanderbilt University26 enrolled1 locationNCT02646475
Recruiting
Phase 1Phase 2
Roxadustat's Effect on Heart, Nutrition, and Inflammation in Hemodialysis Patients
Cardiovascular Diseases (CVD)Kidney Failure, ChronicMalnutrition-Inflammation Syndrome+1 more
Mansoura University46 enrolled1 locationNCT06903559
Recruiting
Phase 1
A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study
NeoplasmsMultiple MyelomaCardiovascular Diseases+11 more
OriCell Therapeutics Co., Ltd.81 enrolled1 locationNCT06271252
Recruiting
Phase 1Phase 2
A Study to Evaluate Mesenchymal Stem Cell Product StromaForte's Effect on Cardiovascular Events
Cardiovascular Diseases
Cellcolabs Clinical LTD.100 enrolled1 locationNCT06087848
Recruiting
Phase 1
Phase 1 study of BRB-002 in healthy male volunteers
Cardiovascular
Bitterroot Australia Pty Ltd48 enrolled1 locationACTRN12624000405516
Not Yet Recruiting
Phase 1
A Safety and Tolerability Study Evaluating CTX320 in Subjects With Elevated Lipoprotein(a) and a History of Atherosclerotic Cardiovascular Disease or Calcific Aortic Valve Stenosis.
Elevated Lipoprotein(a)Atherosclerotic Cardiovascular DiseaseCalcific Aortic Valve Stenosis
CRISPR Therapeutics AG24 enrolled1 locationACTRN12623001095651
Completed
Phase 1
A single -ascending dose study of TX000045 in healthy participants
Cardiovascular
Tectonic Therapeutic75 enrolled1 locationACTRN12623001054606
Recruiting
Phase 1Phase 2
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
Sexual DysfunctionAutoimmune DiseasesNeurologic Disorders+8 more
Thomas Advanced Medical LLC5,000 enrolled1 locationNCT04684602
Completed
Phase 1
Evaluating the Plasma Pharmacokinetics of CRD-102 in patients with Heart Failure following long term administration
Cardiovascular - heart failure
Cardiora Pty Ltd45 enrolled1 locationACTRN12616000120471
Recruiting
Phase 1
A pilot trial assessing the effect of fish oil on leptin and adiponectin levels in overweight/obese individuals.
ObesityCardiovascular Disease
Centre for Integrative Clinical and Molecular Medicine, University of Queensland48 enrolled1 locationACTRN12610000983000
Not Yet Recruiting
Phase 1
The Role of Androgens in Angiogenesis and Endothelial Progenitor Cell Mobilisation
Cardiovascular effects of testosterone therapy in healthy men, specifically mobilisation and function of endothelial progenitor cells.
Dr. Martin Ng, Royal Prince Alfred Hospital.40 enrolledACTRN12607000363482