Empyema Clinical Trials

10 recruitingLast updated: June 17, 2026

There are 10 actively recruiting empyema clinical trials across 7 countries. Studies span Not Applicable, Phase 4. Top locations include Chapel Hill, North Carolina, United States, Asyut, Egypt, Belgrade, Serbia. Updated daily from ClinicalTrials.gov.


Empyema Trials at a Glance

10 actively recruiting trials for empyema are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Chapel Hill, Asyut, and Belgrade. Lead sponsors running empyema studies include Assiut University, Fayoum University, and Aleksandar Sovtic.

Browse empyema trials by phase

Treatments under study

About Empyema Clinical Trials

Looking for clinical trials for Empyema? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Empyema trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Empyema clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 110 of 10 trials

Recruiting
Phase 4

Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema

EmpyemaPleural EffusionPleural Effusion Associated With Pulmonary Infection+5 more
University of North Carolina, Chapel Hill270 enrolled6 locationsNCT07095361
Recruiting
Not Applicable

Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Pleural infectionEmpyema, Pleural
Vanderbilt University Medical Center96 enrolled5 locationsNCT06427538
Recruiting
Not Applicable

Fungal Empyema Thoracis

Pleural EmpyemaPyothoraxFungal Infection Lungs
University of Health Sciences Lahore50 enrolled1 locationNCT07337993
Recruiting

UNC Pleural Fluid Registry

Breast CancerLung CancerLung Infection+2 more
UNC Lineberger Comprehensive Cancer Center9,999 enrolled1 locationNCT05620329
Recruiting
Not Applicable

VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema

Pleural Empyema
Thomas Decker Christensen184 enrolled3 locationsNCT04095676
Recruiting
Not Applicable

Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema

Empyema, Pleural
Fayoum University90 enrolled1 locationNCT06787885
Recruiting
Not Applicable

Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion

Complicated Pleural Effusion/ Empyema
First Affiliated Hospital of Ningbo University260 enrolled1 locationNCT06734481
Recruiting

Complicated Pneumonia (CP) in Children in South-East Europe

Pneumonia, NecrotizingLung AbscessEmpyema, Pleural
Aleksandar Sovtic300 enrolled1 locationNCT06657898
Recruiting
Not Applicable

Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema

Thoracic Empyema
Assiut University73 enrolled1 locationNCT06424457
Recruiting

Clinical features, patterns of care and outcome of children with empyema: A retrospective review at a Regional Tropical Hospital

Acute pneumoniaEmpyema thoracis
The Townsville Hospital, Institute of Women's and Child Health, Department of Paediatrics45 enrolled1 locationACTRN12613000814774