Endocarditis Clinical Trials

40 recruitingLast updated: July 25, 2026

There are 40 actively recruiting endocarditis clinical trials across 19 countries. Studies span Not Applicable, Phase 4, Phase 3, Phase 2. Top locations include Montreal, Quebec, Canada, Paris, France, Copenhagen, Denmark. Updated daily from ClinicalTrials.gov.


Endocarditis Trials at a Glance

40 actively recruiting trials for endocarditis are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Montreal, Paris, and Copenhagen. Lead sponsors running endocarditis studies include Todd C. Lee MD MPH FIDSA, Assistance Publique - Hôpitaux de Paris, and Nantes University Hospital.

Browse endocarditis trials by phase

Treatments under study

About Endocarditis Clinical Trials

Looking for clinical trials for Endocarditis? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Endocarditis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Endocarditis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 40 trials

Recruiting
Not Applicable

Reducing Risk for Infective Endocarditis

BacteremiaInfective Endocarditis
Wake Forest University Health Sciences320 enrolled6 locationsNCT05721781
Recruiting
Phase 4

Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia

Staphylococcus Aureus BacteremiaStaphylococcus Aureus EndocarditisStaphylococcus Aureus Septicemia+2 more
Todd C. Lee MD MPH FIDSA300 enrolled18 locationsNCT06637332
Recruiting

Barts Endocarditis Research Registry

EndocarditisInfective EndocarditisEndocarditis, Bacterial
Queen Mary University of London1,000 enrolled1 locationNCT06434012
Recruiting
Phase 4

Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis

Endocarditis Infective
Fundacion Clinic per a la Recerca Biomédica360 enrolled20 locationsNCT05398679
Recruiting
Not Applicable

Etiologic Diagnosis Algorithm in Infective Endocarditis

Infective EndocarditisMicrobiology
I.M. Sechenov First Moscow State Medical University128 enrolled3 locationsNCT07682389
Recruiting
Phase 3

Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis

Infective Endocarditis
Nantes University Hospital422 enrolled31 locationsNCT07345325
Recruiting

Study of the Prognosis of Infectious Endocarditis (EPEI)

Endocarditis Infective
Centre Hospitalier Universitaire, Amiens645 enrolled1 locationNCT03211975
Recruiting
Phase 4

Anemia Therapy in Patients With Infective Endocarditis

Severe AnemiaInfective Endocarditis (IE)
Rigshospitalet, Denmark74 enrolled1 locationNCT07523646
Recruiting
Phase 2

Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia

Staphylococcus Aureus BacteremiaStaphylococcus Aureus EndocarditisStaphylococcus Aureus Septicemia+1 more
Todd C. Lee MD MPH FIDSA60 enrolled6 locationsNCT04886284
Recruiting
Not Applicable

The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.

Heart Valve DiseaseInfective Endocarditis (IE)
Region Skane1,300 enrolled5 locationsNCT07511673
Recruiting

Clinical and Diagnostic Features of Endocarditis

Endocarditis
University Hospital of Ferrara500 enrolled1 locationNCT05547607
Recruiting

INfectious DIsease REgistry BIObank

Bone and joint infectionsInfective EndocarditisCentral Nervous System Infections+4 more
IRCCS San Raffaele10,000 enrolled1 locationNCT06418048
Recruiting
Not Applicable

Healthrelated Quality of Life and Experiences of a Heart Rehabilitation Programme After Care for Infective Endocarditis.

Patient ParticipationBacterial InfectionsInfective Endocarditis+1 more
Region Halland50 enrolled1 locationNCT06704048
Recruiting
Not Applicable

CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.

Infective Endocarditis
Nantes University Hospital170 enrolled10 locationsNCT06269679
Recruiting
Phase 4

Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia

Staphylococcus Aureus BacteremiaStaphylococcus Aureus EndocarditisStaphylococcus Aureus Septicemia+3 more
McGill University Health Centre/Research Institute of the McGill University Health Centre300 enrolled1 locationNCT06650501
Recruiting
Phase 4

Clopidogrel vs. Aspirin for Cardiovascular Risk Reduction in Patients With S. Aureus Bacteremia

Staphylococcus Aureus EndocarditisStaphylococcus Aureus SepticemiaStaphylococcus Aureus Bloodstream Infection
Todd C. Lee MD MPH FIDSA300 enrolled1 locationNCT06650488
Recruiting
Phase 3

Bacteriophages in Addition to Antibiotics for the Treatment of Patients With Infective Endocarditis

Endocarditis, Bacterial
University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba)30 enrolled1 locationNCT06870409
Recruiting
Phase 2

Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis

Infective Endocarditis
University Hospital, Bordeaux40 enrolled1 locationNCT05446376
Recruiting

San Matteo Endocarditis Registry STEADY

Endocarditis Infective
Fondazione IRCCS Policlinico San Matteo di Pavia418 enrolled1 locationNCT07346222
Recruiting
Not Applicable

Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis

Endocarditis
Centre Henri Becquerel30 enrolled1 locationNCT05146180