Extubation Clinical Trials

24 recruitingLast updated: June 21, 2026

There are 24 actively recruiting extubation clinical trials across 25 countries. Studies span Not Applicable, Phase 2, Phase 4. Top locations include Toronto, Ontario, Canada, Winston-Salem, North Carolina, United States, Lille, France. Updated daily from ClinicalTrials.gov.


Extubation Trials at a Glance

24 actively recruiting trials for extubation are listed on ClinicalTrialsFinder across 6 cities in 25 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Toronto, Winston-Salem, and Lille. Lead sponsors running extubation studies include Centre Hospitalier Intercommunal Creteil, Centre Hospitalier Régional d'Orléans, and Ain Shams University.

Browse extubation trials by phase

Treatments under study

About Extubation Clinical Trials

Looking for clinical trials for Extubation? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Extubation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Extubation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 24 trials

Recruiting

EXtubation Related Complications - the EXTUBE Study (EXTUBE)

Extubation
University Health Network, Toronto3,000 enrolled32 locationsNCT06442930
Recruiting
Not Applicable

BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia

PaediatricEndotracheal ExtubationAirway Anesthesia
Telethon Kids Institute1,400 enrolled8 locationsNCT07204990
Recruiting
Not Applicable

Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units

Post Extubation Respiratory Failure
Poitiers University Hospital670 enrolled47 locationsNCT05686850
Recruiting
Phase 4

Inhaled Sedation in Critically Ill Patients

SedationAirway Extubation
Instituto de Investigación Hospital Universitario La Paz620 enrolled22 locationsNCT07000526
Recruiting

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score

extubation failureRespiratory FailureWeaning Invasive Mechanical Ventilation+5 more
Medipol University470 enrolled7 locationsNCT07098611
Recruiting

Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.

extubation failureQuality of Life (QOL)Mortality+5 more
Universita degli Studi di Genova2,400 enrolled1 locationNCT07093125
Recruiting
Not Applicable

Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support

Airway Extubation
Ottawa Hospital Research Institute200 enrolled12 locationsNCT05506904
Recruiting

The Rapid Shallow Breathing Index (RSBI) is a Widely Used Predictor for Weaning Patients From Mechanical Ventilation This Study Aims to Determine the Predictive Value of RSBI Measurements for Extubation Success in Mechanically Ventilated ICU Patients

Ventilated Patient in Intensive CareFailure of Extubation
Ain Shams University70 enrolled1 locationNCT07467265
Recruiting

Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.

extubation failurePreterm neonateMechanical Ventilation+3 more
Centre Hospitalier Intercommunal Creteil100 enrolled31 locationsNCT06808997
Recruiting

Is High Resolution Endotracheal Tube Leak Data Indicative of the Development of Post-extubation Stridor in Children?

Post Extubation Stridor
University Hospital, Antwerp400 enrolled1 locationNCT07414472
Recruiting
Not Applicable

Site of Tracheal Extubation and Operating Room Efficiency During Robot-assisted Surgery

Postoperative ComplicationsRobotic Surgical ProceduresAirway Extubation+2 more
Peking University First Hospital218 enrolled1 locationNCT07332806
Recruiting
Not Applicable

Does Positive Pressure Extubation Reduce Postoperative Desaturation?

Postoperative ComplicationsExtubationLung Ultrasound Score
University Hospital, Lille264 enrolled1 locationNCT05295095
Recruiting
Not Applicable

Endotracheal Suctionning During Positive Pressure Extubation in ICU

Weaning Invasive Mechanical VentilationExtubationOxygen Saturation Measurement+2 more
Centre Hospitalier Régional d'Orléans120 enrolled1 locationNCT07130123
Recruiting

Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

Extubation
Wake Forest University Health Sciences600 enrolled2 locationsNCT05837936
Recruiting
Not Applicable

Spontaneous Breathing Trials Using Pressure Support or T-Piece in Overweight and Obese Patients

Respiratory FailureMechanical VentilationObesity &Amp; Overweight+1 more
Taipei Medical University Hospital100 enrolled1 locationNCT07114289
Recruiting
Not Applicable

Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

extubation failureObesity, Morbid
Rush University Medical Center250 enrolled5 locationsNCT05918575
Recruiting
Not Applicable

The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

extubation failureDeathBronchopulmonary Dysplasia
University of Pennsylvania478 enrolled20 locationsNCT05446272
Recruiting
Not Applicable

High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery

Heart Defects, CongenitalExtubationRespiration, Artificial+1 more
Indonesia University114 enrolled1 locationNCT07059689
Recruiting
Not Applicable

Modified Deep Extubation vs. Standard Awake Extubation

Extubation
Samuel Lunenfeld Research Institute, Mount Sinai Hospital60 enrolled1 locationNCT06318715
Recruiting
Not Applicable

Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula

Respiratory Failure With HypoxiaExtubation Readiness
National Taiwan University Hospital480 enrolled1 locationNCT07007715