Phase 1 Infection Clinical Trials
144 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 144 trials
Recruiting
Phase 1
A Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus
Congenital Cytomegalovirus Infection
National Institute of Allergy and Infectious Diseases (NIAID)12 enrolled10 locationsNCT06118515
Recruiting
Phase 1
MK-4646 Multiple Dose Trial in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) (MK-4646-003)
HIV Infection
Merck Sharp & Dohme LLC28 enrolled2 locationsNCT07042945
Recruiting
Phase 1Phase 2
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)1,120 enrolled46 locationsNCT02140255
Recruiting
Phase 1
NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)
InfectionChronic Granulomatous Disease
National Institute of Allergy and Infectious Diseases (NIAID)25 enrolled1 locationNCT05189925
Recruiting
Phase 1Phase 2
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
NeutropeniaInfectionsWarts+2 more
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled1 locationNCT00967785
Recruiting
Phase 1Phase 2
Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age
HIV-1-infection
National Institute of Allergy and Infectious Diseases (NIAID)90 enrolled12 locationsNCT05660980
Recruiting
Phase 1Phase 2
A Study on the Safety and Immune Response of a Urinary Tract Infection (UTI) Vaccine in Adults 18-64 Years of Age and Clinical Efficacy in Females 18-64 Years of Age
Urinary Tract Infections
GlaxoSmithKline448 enrolled8 locationsNCT06702449
Recruiting
Phase 1
A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)
Pneumococcal Infection
Merck Sharp & Dohme LLC210 enrolled14 locationsNCT07300267
Recruiting
Phase 1
First Time in Human Study of Long Acting VH4524184 Formulations
HIV Infections
ViiV Healthcare268 enrolled3 locationsNCT06310551
Recruiting
Phase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)40 enrolled7 locationsNCT06665646
Recruiting
Phase 1
Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmSymptomatic COVID-19 Infection Laboratory-Confirmed+4 more
M.D. Anderson Cancer Center30 enrolled1 locationNCT05101213
Recruiting
Phase 1Phase 2
Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)
Viral InfectionPrimary Immune Deficiency Disorder
New York Medical College40 enrolled7 locationsNCT04197596
Recruiting
Phase 1
Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
HIV InfectionRecurrent Non-Hodgkin LymphomaRefractory Non-Hodgkin Lymphoma+11 more
AIDS Malignancy Consortium20 enrolled6 locationsNCT05077527
Recruiting
Phase 1Phase 2
Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmCOVID-19 Infection+2 more
M.D. Anderson Cancer Center70 enrolled1 locationNCT04565665
Recruiting
Phase 1
HIV Therapeutic DNA Vaccine (ICVAX) Phase I Clinical Trial in Hong Kong
Human Immunodeficiency VirusHuman Immunodeficiency Virus I Infection
Immuno Cure Holding (HK) Limited22 enrolled1 locationNCT07530198
Recruiting
Phase 1Phase 2
CAR-T Cells for HIV Infection
HIV Infections
Steven Deeks18 enrolled2 locationsNCT04648046
Recruiting
Phase 1
Clinical Study of EBV-TCR-T Cells for EBV Infection After Allogenic HSCT
EBV Infection After Allogenic HSCT
Chinese PLA General Hospital12 enrolled1 locationNCT06119256
Recruiting
Phase 1
Epstein-Barr Virus (EBV) gH/gL/gp42-Ferritin Nanoparticle Vaccine With or Without gp350-Ferritin in Healthy Adults With or Without EBV Infection
EBVEpstein-Barr Virus InfectionInfectious Mononucleosis+1 more
National Institute of Allergy and Infectious Diseases (NIAID)750 enrolled1 locationNCT06908096
Recruiting
Phase 1Phase 2
FMT for the Decolonization of Carbapenem-resistant Enterobacteriaceae
Enterobacteriaceae InfectionsMulti-antibiotic Resistance
Fondazione Policlinico Universitario Agostino Gemelli IRCCS52 enrolled1 locationNCT04759001
Recruiting
Phase 1
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of GIGA-2339 in Participants With Chronic Hepatitis B Virus Infection
Hepatitis B Virus Infection
GigaGen, Inc.48 enrolled16 locationsNCT07024641