Knee pain Clinical Trials

50 recruitingLast updated: June 19, 2026

There are 50 actively recruiting knee pain clinical trials across 19 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Houston, Texas, United States, Hong Kong, Hong Kong, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Knee pain Trials at a Glance

50 actively recruiting trials for knee pain are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 29 trials, with the heaviest enrollment activity in Houston, Hong Kong, and New York. Lead sponsors running knee pain studies include Ottawa Hospital Research Institute, The Hong Kong Polytechnic University, and Consorci Sanitari de l'Alt Penedès i Garraf.

Browse knee pain trials by phase

Treatments under study

About Knee pain Clinical Trials

Looking for clinical trials for Knee pain? There are currently 14 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Knee pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Knee pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 50 trials

Recruiting
Phase 2

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Post Operative PainChronic PainKnee Pain Chronic
University Health Network, Toronto400 enrolled3 locationsNCT06123715
Recruiting

FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis

Knee painKnee OsteoarthritisInflamation+1 more
University of California, San Francisco50 enrolled1 locationNCT07625150
Recruiting
Not Applicable

NT-II™ Collagen for Joint Discomfort and Function

Joint DiscomfortActivity-Related Knee DiscomfortFunctional Joint Pain+2 more
Hofseth Biocare ASA120 enrolled1 locationNCT07119645
Recruiting
Phase 3

Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

Osteoarthritis Knee Pain
Saol Therapeutics Inc150 enrolled20 locationsNCT07226258
Recruiting
Phase 2

Pain Reprocessing Therapy in Post-Operative Knee Pain

Pain, ChronicKnee Pain Chronic
University of Colorado, Denver110 enrolled2 locationsNCT06800209
Recruiting
Not Applicable

Focused Extracorporeal Shockwave Therapy for Knee Arthritis

Knee OsteoarthritisKnee Pain ChronicBone Marrow Edema
Kessler Foundation15 enrolled2 locationsNCT05596591
Recruiting
Not Applicable

Advanced Brain Imaging-TKA (fMRI-TKA)

Patient SatisfactionKnee Pain ChronicKnee Osteoarthritis (Knee OA)+2 more
Ottawa Hospital Research Institute50 enrolled1 locationNCT07464080
Recruiting
Not Applicable

Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

Chronic Knee PainPeripheral Nerve StimulationGenicular Nerves
M.D. Anderson Cancer Center45 enrolled1 locationNCT06004882
Recruiting
Not Applicable

The Effects of Dry Needling on Patients With Knee Pain

Patellofemoral Pain SyndromeAnterior Knee Pain Syndrome
Ohio State University120 enrolled1 locationNCT02890485
Recruiting

Diagnostic Validity Ofclinical Tests for Infrapatellar Fat Pad Impingement Syndrome

Anterior Knee Pain
Hopitaux de Saint-Maurice50 enrolled1 locationNCT06971601
Recruiting
Not Applicable

Genicular Nerve Block for Knee Pain in the ED

Knee pain
University of Pennsylvania34 enrolled4 locationsNCT07158736
Recruiting
Not Applicable

Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis

Knee OsteoarthristisKnee Pain ArthritisOsteearthritis
University of Karachi150 enrolled2 locationsNCT07396233
Recruiting
Not Applicable

Percutaneous Transcatheter Genicular Embolization in Osteoarthritis

osteoarthritic knee painOsteo Arthritis of the KneeOsteoarthitis
Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.20 enrolled1 locationNCT07361198
Recruiting
Phase 4

Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty

Osteoarthritis, KneeKnee Pain ChronicArthropathy of Knee
Poznan University of Medical Sciences90 enrolled1 locationNCT07180953
Recruiting

Individual Differences in Gait and Osteoarthritis Pain

Chronic PainChronic Knee PainKnee osteoarthritis (OA)
University of Pittsburgh300 enrolled1 locationNCT07308873
Recruiting
Not Applicable

Long-Term Study of CartiPRO for Knee Pain Due to Osteoarthritis or Cartilage Damage

Knee OsteoarthritisOsteoarthritisDegenerative Joint Disease of Knee+2 more
DALIM TISSEN Co., Ltd.194 enrolled5 locationsNCT07267793
Recruiting

Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

Rheumatoid ArthritisOsteoarthritis, KneePolyarthritis+6 more
Zimmer Biomet760 enrolled16 locationsNCT05787821
Recruiting
Not Applicable

Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis

Chronic Knee PainKnee Pain ArthritisOsteoarthritis(OA) of the knee
FUSMobile Inc.10 enrolled1 locationNCT07178951
Recruiting
Not Applicable

Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain.

Chronic Knee PainChronic post-surgical painChronic post operative pain
Consorci Sanitari de l'Alt Penedès i Garraf86 enrolled1 locationNCT05920382
Recruiting

Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive

FibromyalgiaChronic Knee Pain
University of Nottingham135 enrolled1 locationNCT07281651