Knee pain Clinical Trials

10 recruiting

Knee pain Trials at a Glance

38 actively recruiting trials for knee pain are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 21 trials, with the heaviest enrollment activity in Houston, New York, and Charlotte. Lead sponsors running knee pain studies include Centro Hospitalar Universitario do Algarve, DALIM TISSEN Co., Ltd., and BioPoly LLC.

Browse knee pain trials by phase

Treatments under study

About Knee pain Clinical Trials

Looking for clinical trials for Knee pain? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Knee pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Knee pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 38 trials

Recruiting
Phase 2

Pain Reprocessing Therapy in Post-Operative Knee Pain

Pain, ChronicKnee Pain Chronic
University of Colorado, Denver110 enrolled2 locationsNCT06800209
Recruiting
Phase 3

Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

Osteoarthritis Knee Pain
Saol Therapeutics Inc150 enrolled18 locationsNCT07226258
Recruiting
Not Applicable

Focused Extracorporeal Shockwave Therapy for Knee Arthritis

Knee OsteoarthritisKnee Pain ChronicBone Marrow Edema
Kessler Foundation15 enrolled2 locationsNCT05596591
Recruiting
Not Applicable

Advanced Brain Imaging-TKA (fMRI-TKA)

Patient SatisfactionKnee Pain ChronicKnee Osteoarthritis (Knee OA)+2 more
Ottawa Hospital Research Institute50 enrolled1 locationNCT07464080
Recruiting
Not Applicable

Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

Chronic Knee PainPeripheral Nerve StimulationGenicular Nerves
M.D. Anderson Cancer Center45 enrolled1 locationNCT06004882
Recruiting
Not Applicable

The Effects of Dry Needling on Patients With Knee Pain

Patellofemoral Pain SyndromeAnterior Knee Pain Syndrome
Ohio State University120 enrolled1 locationNCT02890485
Recruiting

Diagnostic Validity Ofclinical Tests for Infrapatellar Fat Pad Impingement Syndrome

Anterior Knee Pain
Hopitaux de Saint-Maurice50 enrolled1 locationNCT06971601
Recruiting
Not Applicable

Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis

Knee OsteoarthristisKnee Pain ArthritisOsteearthritis
University of Karachi150 enrolled2 locationsNCT07396233
Recruiting
Phase 4

Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty

Osteoarthritis, KneeKnee Pain ChronicArthropathy of Knee
Poznan University of Medical Sciences90 enrolled1 locationNCT07180953
Recruiting
Not Applicable

Long-Term Study of CartiPRO for Knee Pain Due to Osteoarthritis or Cartilage Damage

Knee OsteoarthritisOsteoarthritisDegenerative Joint Disease of Knee+2 more
DALIM TISSEN Co., Ltd.194 enrolled5 locationsNCT07267793
Recruiting

Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

Rheumatoid ArthritisOsteoarthritis, KneePolyarthritis+6 more
Zimmer Biomet760 enrolled16 locationsNCT05787821
Recruiting

Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive

FibromyalgiaChronic Knee Pain
University of Nottingham135 enrolled1 locationNCT07281651
Recruiting
Not Applicable

Light Therapy on Pain and Synovitis

Knee Pain ChronicLight TherapySynovitis of Knee
The Hong Kong Polytechnic University80 enrolled2 locationsNCT07057063
Recruiting
Not Applicable

Evaluating the Auricular Point Acupressure-Self Management Program for Chronic Musculoskeletal Pain Among Rural Populations

Joint PainChronic Knee PainChronic Pain Management+1 more
The University of Texas Health Science Center, Houston693 enrolled3 locationsNCT07179016
Recruiting

Comparison of the Effects of Trigonum Femoral + Distal Adductor Block and Adductor Canal + N.Tibialis Posterior Block on Postoperative Pain in Total Knee Replacement Surgery: A Multicenter Study

postoperative knee pain
ege university60 enrolled1 locationACTRN12625000827437
Recruiting
Phase 2Phase 3

Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery

Chronic Knee PainObesity, Morbid
University of Nove de Julho62 enrolled1 locationNCT05816798
Recruiting

The Effect of RF Genicular Nerve Block Applied in the Preoperative Period on Fast-track Total Knee Arthroplasty

Knee OsteoarthritisKnee Pain Chronic
Pamukkale University60 enrolled1 locationNCT06239649
Recruiting
Not Applicable

Efficacy of Microparticle Geniculate Artery Embolization in Total Knee Prosthesis Patients With Pain Resistant to Medical Treatment. A Prospective Randomized Controlled Trial

Knee Pain ChronicKnee Pain Swelling
Societe Francaise de Rhumatologie112 enrolled11 locationsNCT06466330
Recruiting
Phase 2

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Post Operative PainChronic PainKnee Pain Chronic
University Health Network, Toronto300 enrolled3 locationsNCT06123715
Recruiting

Revised Targets for Knee Radiofrequency Ablation

Osteoarthritis Knee Pain
Centro Hospitalar Universitario do Algarve60 enrolled2 locationsNCT06934421