Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
46 participants
Mar 1, 2021
INTERVENTIONAL
Conditions
Summary
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.
Eligibility
Inclusion Criteria4
- Age: 18-40
- Body Mass Index: 27-45 kg/m2
- No regularly planned exercise/physical activity for at least 6 months
- Women must have regularly occurring menses and must be premenopausal
Exclusion Criteria5
- Evidence/history of cardiovascular or metabolic disease
- Medications known to affect lipid or glucose metabolism, or inflammation
- Weight instability ≥ ± 6 pounds in the last 3 months
- Tobacco or e-cigarette users
- Women must not be pregnant or actively lactating
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Participants will complete a moderate intensity continuous exercise 4 days/week.
Participants will remain sedentary throughout the duration of the study.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04812314