Phase 3 Metastasis Clinical Trials
16 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–16 of 16 trials
Recruiting
Phase 3
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
Ovarian NeoplasmsNeoplasm MetastasisFallopian Tube Neoplasms+1 more
Eli Lilly and Company1,630 enrolled261 locationsNCT07213804
Recruiting
Phase 3
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
Breast NeoplasmsNeoplasm Metastasis
Eli Lilly and Company920 enrolled327 locationsNCT07174336
Recruiting
Phase 3
A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC
Colorectal NeoplasmsNeoplasm MetastasisGastrointestinal Neoplasms+2 more
Sun Yat-sen University280 enrolled1 locationNCT03303495
Recruiting
Phase 3
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Carcinoma, Non-Small Cell LungNeoplasm Metastasis
Eli Lilly and Company1,264 enrolled422 locationsNCT06119581
Recruiting
Phase 3
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
Urinary Bladder NeoplasmsNeoplasm MetastasisCarcinoma, Transitional Cell
Eli Lilly and Company450 enrolled284 locationsNCT07218380
Recruiting
Phase 2Phase 3
Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
Prostate CancerMetastatic Prostate CancerOligometastasis+3 more
VA Office of Research and Development464 enrolled20 locationsNCT04787744
Recruiting
Phase 3
A Study Evaluating Furmonertinib Plus Platinum-based Doublet Chemotherapy Versus Osimertinib in Patients With Epidermal Growth Factor Receptor (EGFR) Sensitizing Mutation-Positive Non-squamous Non-Small Cell Lung Cancer (NSCLC) and Brain Metastases
NSCLC Patients With Brain Metastasis
Allist Pharmaceuticals, Inc.380 enrolled1 locationNCT06970639
Recruiting
Phase 3
Metastasis-directed Therapy for Oligometastases of Breast Cancer
Breast CancerMetastatic Breast CancerOligometastasis
Tokyo Medical and Dental University340 enrolled1 locationNCT06135714
Recruiting
Phase 3
Stereotactic Ablative Radiotherapy (SABR) for the Treatment of Patients With Metastatic Cancer, ID-COMET Trial
Prostate CancerLung CancerColo-rectal Cancer+1 more
Roswell Park Cancer Institute800 enrolled1 locationNCT06563388
Recruiting
Phase 3
18F-FLUC PET/MR in Patients With Brain Mets
Brain MetastasisRadiation TherapyImmunotherapy, Active
University of Wisconsin, Madison30 enrolled1 locationNCT06159335
Recruiting
Phase 3
PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Salvage Locoregional Radiotherapy in De Novo Metastatic NPC
Nasopharangeal CancerDistant Metastasis
Sun Yat-sen University260 enrolled5 locationsNCT07235319
Recruiting
Phase 2Phase 3
COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases
Colorectal, CancerLiver MetastasesUnresectable Solid Tumor+1 more
Amsterdam UMC, location VUmc78 enrolled1 locationNCT06185556
Recruiting
Phase 3
Metastasis-directed Therapy for Oligorecurrent Prostate Cancer
Prostate CancerMetastatic CancerProstate Cancer Metastatic+4 more
Universitaire Ziekenhuizen KU Leuven873 enrolled1 locationNCT05352178
Recruiting
Phase 3
Selective Lymph Node Dissection for cT1N0M0 Invasive NSCLC With CTR>0.5 Located in the Apical Segment (ECTOP-1018)
Lymph Node MetastasisLung Adenocarcinoma
Fudan University634 enrolled1 locationNCT06031246
Recruiting
Phase 3
COLLISION RELAPSE Trial
Colorectal, CancerSurgeryLiver Metastases+3 more
Amsterdam UMC, location VUmc360 enrolled1 locationNCT05861505
Recruiting
Phase 2Phase 3
Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer
Non-small Cell Lung Cancer (NSCLC)Brain Metastasis
Chang Gung Memorial Hospital90 enrolled1 locationNCT02448992