Mitochondria Clinical Trials

55 recruitingLast updated: May 21, 2026

There are 55 actively recruiting mitochondria clinical trials across 22 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4. Top locations include New York, New York, United States, Philadelphia, Pennsylvania, United States, San Diego, California, United States. Updated daily from ClinicalTrials.gov.


Mitochondria Trials at a Glance

55 actively recruiting trials for mitochondria are listed on ClinicalTrialsFinder across 6 cities in 22 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in New York, Philadelphia, and San Diego. Lead sponsors running mitochondria studies include Children's Hospital of Philadelphia, Centre Hospitalier Universitaire de Nice, and Columbia University.

Browse mitochondria trials by phase

About Mitochondria Clinical Trials

Looking for clinical trials for Mitochondria? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mitochondria trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mitochondria clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 55 trials

Recruiting

Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity

Mitochondrial disease
National Human Genome Research Institute (NHGRI)400 enrolled1 locationNCT04419870
Recruiting
Phase 2

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

Insulin ResistanceChronic Kidney DiseasesFatigue+4 more
University of California, Davis80 enrolled2 locationsNCT04984226
Recruiting

The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism

Oxidative Phosphorylation DeficienciesElectron Transport Chain Disorders, MitochondrialMitochondrial Disorders+1 more
National Human Genome Research Institute (NHGRI)500 enrolled1 locationNCT01780168
Recruiting
Phase 3

Coenzyme Q10 for Gulf War Illness: A Replication Study

Gulf War SyndromePersian Gulf SyndromeMitochondrial Disorder, Respiratory Chain
University of California, San Diego192 enrolled1 locationNCT06515184
Recruiting

Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders

Brain TumorEpilepsyAutism Spectrum Disorder+3 more
Southwest Autism Research & Resource Center500 enrolled2 locationsNCT04322734
Recruiting

The Natural History of Mitochondrial Diseases

Genetic DiseaseMitochondrial DiseasesNeurological Diseases or Conditions
Neuroscience Research Australia500 enrolled1 locationNCT06504433
Recruiting

Patterns of Neurodevelopmental Disorders

EpilepsyAutism Spectrum DisorderNeurodevelopmental Disorders+5 more
Richard Frye1,000 enrolled1 locationNCT06213090
Recruiting
Phase 2

Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease

Primary Mitochondrial Disease
Abliva AB180 enrolled35 locationsNCT05650229
Recruiting
Not Applicable

Kaempferol Absorption and Pharmacokinetics Evaluation

longevityHealthy VolunteersNo Disease+2 more
University of Pittsburgh120 enrolled3 locationsNCT07322406
Recruiting
Not Applicable

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

Myasthenia GravisAmyotrophic Lateral SclerosisNeuromuscular Diseases (NMD)+15 more
University of Missouri-Columbia50 enrolled1 locationNCT07478172
Recruiting
Not Applicable

Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy

Mitochondrial MyopathyMitochondrial Diseases
University of Copenhagen22 enrolled1 locationNCT07450690
Recruiting
Not Applicable

Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men

Mitochondrial EnergeticsDietary NitrateDisuse Atrophy (Muscle) of Lower Leg
Indiana University24 enrolled1 locationNCT07161973
Recruiting

Mitochondrial Substrate Utilization in the Diabetic Human Heart

Heart FailureInsulin ResistanceMitochondrial Diseases+2 more
Heinrich-Heine University, Duesseldorf500 enrolled1 locationNCT05958706
Recruiting
Phase 1

Validation of Oxygen Nanosensor in Mitochondrial Myopathy

Mitochondrial DiseasesMItochondrial Myopathies
Children's Hospital of Philadelphia24 enrolled1 locationNCT04086329
Recruiting
Phase 1

Validation of Nanosensor Oxygen Measurement

Mitochondrial diseaseMItochondrial Myopathies
Children's Hospital of Philadelphia96 enrolled1 locationNCT06819683
Recruiting

Neurometabolic Profile of Individuals With Primary Mitochondrial Disease

Primary Mitochondrial Disease
Children's Hospital of Philadelphia30 enrolled1 locationNCT06890520
Recruiting

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

Mitochondrial DiseasesMitochondrial DisordersMitochondrial Genetic Disorders+2 more
Columbia University1,000 enrolled17 locationsNCT01694940
Recruiting

Mitochondrial Disease-associated ImmunoDeficiencies

Mitochondrial Disorders
University Hospital, Bordeaux60 enrolled2 locationsNCT06213103
Recruiting
Phase 3

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

Mitochondrial DiseasesMaternally Inherited Diabetes and Deafness (MIDD)Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)+1 more
Khondrion BV220 enrolled10 locationsNCT06451757
Recruiting

Natural History Study - Mitochondrial Disease

MELAS or m.3243 A>G Mitochondrial DNA Mutation Carrier
Columbia University300 enrolled1 locationNCT01532791