Mitochondria Clinical Trials

2 recruiting

Frequently Asked Questions

Common questions about Mitochondria clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 47 trials

Recruiting

The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism

Oxidative Phosphorylation DeficienciesElectron Transport Chain Disorders, MitochondrialMitochondrial Disorders+1 more
National Human Genome Research Institute (NHGRI)500 enrolled1 locationNCT01780168
Recruiting
Not Applicable

Kaempferol Absorption and Pharmacokinetics Evaluation

No DiseaseMitochondria Health
University of Pittsburgh120 enrolled3 locationsNCT07322406
Recruiting
Not Applicable

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

Myasthenia GravisAmyotrophic Lateral SclerosisNeuromuscular Diseases (NMD)+15 more
University of Missouri-Columbia50 enrolled1 locationNCT07478172
Recruiting
Not Applicable

Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy

Mitochondrial MyopathyMitochondrial Diseases
University of Copenhagen22 enrolled1 locationNCT07450690
Recruiting
Not Applicable

Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men

Mitochondrial EnergeticsDietary NitrateDisuse Atrophy (Muscle) of Lower Leg
Indiana University24 enrolled1 locationNCT07161973
Recruiting

Mitochondrial Substrate Utilization in the Diabetic Human Heart

Heart FailureInsulin ResistanceMitochondrial Diseases+2 more
Heinrich-Heine University, Duesseldorf500 enrolled1 locationNCT05958706
Recruiting
Phase 1

Validation of Nanosensor Oxygen Measurement

MItochondrial Myopathies
Children's Hospital of Philadelphia96 enrolled1 locationNCT06819683
Recruiting

Neurometabolic Profile of Individuals With Primary Mitochondrial Disease

Primary Mitochondrial Disease
Children's Hospital of Philadelphia30 enrolled1 locationNCT06890520
Recruiting

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

Mitochondrial DiseasesMitochondrial DisordersMitochondrial Genetic Disorders+2 more
Columbia University1,000 enrolled17 locationsNCT01694940
Recruiting

Mitochondrial Disease-associated ImmunoDeficiencies

Mitochondrial Disorders
University Hospital, Bordeaux60 enrolled2 locationsNCT06213103
Recruiting
Phase 3

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

Mitochondrial DiseasesMaternally Inherited Diabetes and Deafness (MIDD)Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)+1 more
Khondrion BV220 enrolled10 locationsNCT06451757
Recruiting

Natural History Study - Mitochondrial Disease

MELAS or m.3243 A>G Mitochondrial DNA Mutation Carrier
Columbia University300 enrolled1 locationNCT01532791
Recruiting
Phase 4

Quantifying Hepatic Mitochondrial Fluxes in Humans

Non-Alcoholic Fatty Liver DiseaseType 2 DiabetesMitochondrial Metabolism Disorders
The University of Texas Health Science Center at San Antonio60 enrolled2 locationsNCT05305287
Recruiting
Phase 2

Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease

Primary Mitochondrial Disease
Abliva AB180 enrolled23 locationsNCT05650229
Recruiting

Collection of Blood and Skin Samples From Patients With Primary Mitochondrial Diseases and Healthy Volunteers

Primary Mitochondrial Diseases
Minovia Therapeutics Ltd.100 enrolled1 locationNCT06474104
Recruiting
Phase 2Phase 3

MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction

Cognitive ImpairmentMitochondrial AlterationSchizophrenia and Related Disorders
Mclean Hospital100 enrolled3 locationsNCT06191965
Recruiting

Natural History in Primary Mitochondrial Myopathies

Primary Mitochondrial Myopathies
Cristina Domínguez González150 enrolled1 locationNCT05653544
Recruiting

Natural History Study of Mitochondrial Myopathy

Primary Mitochondrial Disease
Children's Hospital of Philadelphia1,300 enrolled1 locationNCT05250375
Recruiting
Phase 2

A Study to Assess TTI-0102 vs Placebo in MELAS Patients

Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)MELAS Syndrome
Thiogenesis Therapeutics, Inc.12 enrolled2 locationsNCT06644534
Recruiting

Mitochondrial Donation: An 18 Month Outcome Study.

Mitochondrial Diseases
Newcastle-upon-Tyne Hospitals NHS Trust25 enrolled1 locationNCT04113447