Musculoskeletal Clinical Trials

147 recruitingLast updated: May 13, 2026

There are 147 actively recruiting musculoskeletal clinical trials across 33 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1, Phase 3. Top locations include Boston, Massachusetts, United States, Istanbul, Turkey (Türkiye), Gainesville, Florida, United States. Updated daily from ClinicalTrials.gov.


Musculoskeletal Trials at a Glance

147 actively recruiting trials for musculoskeletal are listed on ClinicalTrialsFinder across 6 cities in 33 countries. The largest study group is Not Applicable with 80 trials, with the heaviest enrollment activity in Boston, Istanbul, and Gainesville. Lead sponsors running musculoskeletal studies include Chinese University of Hong Kong, University of Florida, and VA Office of Research and Development.

Browse musculoskeletal trials by phase

Treatments under study

About Musculoskeletal Clinical Trials

Looking for clinical trials for Musculoskeletal? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Musculoskeletal trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Musculoskeletal clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 147 trials

Recruiting
Not Applicable

Life-Style Medicine for Chronic Musculoskeletal Pain in Older People

Pain ManagementMusculoskeletal PainChronic Pain+1 more
Chinese University of Hong Kong268 enrolled1 locationNCT07194239
Recruiting
Early Phase 1

Tart Cherry and Omega-3's for Aromatase Inhibitor Musculoskeletal Symptoms

Breast CancerAromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS)Joint Pain
Philip Chang30 enrolled2 locationsNCT06123286
Recruiting
Not Applicable

AI-Assisted Camera-Based Progressive Muscle Relaxation for Office Workers

work-related musculoskeletal disordersMusculoskeletal PainStress, Physiological+1 more
Istanbul Medipol University Hospital60 enrolled1 locationNCT07571967
Recruiting
Not Applicable

Effectiveness of Communication-Focused Pain Neuroscience Education in Chronic Musculoskeletal Pain

Chronic Musculoskeletal Pain
University of Thessaly90 enrolled1 locationNCT07001449
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.10,000 enrolled1 locationNCT07563777
Recruiting

Exercise, Pain Beliefs, and Activity Patterns in Musculoskeletal Pain

Activity LevelMusculoskeletal Pain - Acute and Subacute ConditionsExercise (EX)+1 more
Istinye University55 enrolled1 locationNCT07528807
Recruiting
Not Applicable

Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial

Musculoskeletal PainChronic PainFibromyalgia
G. d'Annunzio University44 enrolled2 locationsNCT07048366
Recruiting
Not Applicable

Osteopathic Manipulative Treatment vs Physiotherapy in Cervicocranial Dysfunction

Cervicogenic headacheDizzinessNeck Pain Musculoskeletal+1 more
Burim Peli50 enrolled1 locationNCT07555873
Recruiting
Not Applicable

Pain Disengagement Training (Open Pilot)

Chronic Musculoskeletal Pain
Massachusetts General Hospital10 enrolled1 locationNCT06870162
Recruiting

Baseline ACL Injury Risk Screening and Normative Data

Musculoskeletal injuryAnterior Cruciate Ligament InjuriesACL Injury
Sanford Health5,000 enrolled1 locationNCT06635668
Recruiting
Phase 4

GLP-1R Actions on Muscle and the Skeleton

ObesityOsteoporosisDrug Effect+2 more
Pennington Biomedical Research Center50 enrolled1 locationNCT07154719
Recruiting
Not Applicable

Exercise and Health Education for Textile Workers: A Pre-Post Study

Musculoskeletal Diseases or ConditionsMusculoskeletal Disorders (MSDs)
Universidad San Jorge38 enrolled1 locationNCT07360626
Recruiting
Not Applicable

Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief

Neck Pain MusculoskeletalCervicalgiaNeck Pain Treatment
Baylor University160 enrolled4 locationsNCT06906107
Recruiting
Phase 3

Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children

Musculoskeletal injuryPediatricsSprain and Strain of Ankle+2 more
University of Calgary60 enrolled2 locationsNCT07145645
Recruiting
Not Applicable

Exoskeleton vs. Standard Lead Apron in EVAR Procedures

Endovascular Aortic RepairRadiation Exposure to OperatorMusculoskeletal Strain+1 more
Samodzielny Publiczny Szpital Kliniczny nr 2 PUM2 enrolled1 locationNCT07528144
Recruiting
Phase 4

Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma?

Musculoskeletal injury
University of Florida200 enrolled1 locationNCT06046859
Recruiting
Not Applicable

Cancer Genetic Testing in Ethnic Populations

Breast CarcinomaHead and Neck CarcinomaMalignant Brain Neoplasm+8 more
Mayo Clinic1,800 enrolled2 locationsNCT04475640
Recruiting

Musculoskeletal Disorders of Postgraduate Dentistry Students and Specialist Dentists

Musculoskeletal DiseasesWork-related Injury
Abant Izzet Baysal University90 enrolled1 locationNCT07088965
Recruiting
Not Applicable

Virtual Reality (VR) Self-Hypnosis Software

Musculoskeletal PainNeuropathic PainNeuralgia
Icahn School of Medicine at Mount Sinai25 enrolled1 locationNCT06398847
Recruiting

Intraoperative Laxity Assessment of ACL Reconstruction, ACL Revision and MAT

Intraoperative Musculoskeletal Injury
Istituto Ortopedico Rizzoli1,500 enrolled1 locationNCT03441165