Musculoskeletal Clinical Trials

162 recruitingLast updated: July 25, 2026

There are 162 actively recruiting musculoskeletal clinical trials across 33 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1, Phase 3. Top locations include Boston, Massachusetts, United States, Istanbul, Turkey (Türkiye), Hong Kong, Hong Kong. Updated daily from ClinicalTrials.gov.


Musculoskeletal Trials at a Glance

162 actively recruiting trials for musculoskeletal are listed on ClinicalTrialsFinder across 6 cities in 33 countries. The largest study group is Not Applicable with 89 trials, with the heaviest enrollment activity in Boston, Istanbul, and Hong Kong. Lead sponsors running musculoskeletal studies include Chinese University of Hong Kong, University of Florida, and VA Office of Research and Development.

Browse musculoskeletal trials by phase

Treatments under study

About Musculoskeletal Clinical Trials

Looking for clinical trials for Musculoskeletal? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Musculoskeletal trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Musculoskeletal clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 162 trials

Recruiting
Not Applicable

Assessing Tissue Response to High-Velocity Thrust Manipulations on Capsule Length and Stiffness at the C5-C6 Facet Joint Capsule

Neck Pain Musculoskeletal
Florida Gulf Coast University40 enrolled1 locationNCT07704853
Recruiting

Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction

Artificial IntelligenceKnee OsteoarthritisDegenerative Knee Disorders+1 more
National Taiwan University Hospital310 enrolled1 locationNCT07721116
Recruiting
Not Applicable

Evaluation of Biomechanical Forced During the Practice of Endoscopic Retrograde Cholangiopancreatography

Musculoskeletal DisordersERCPBiomechanic
Centre Hospitalier Universitaire, Amiens10 enrolled1 locationNCT07691580
Recruiting
Not Applicable

Core Stability vs Scapular Stabilization on Hand Grip Strength in Chronic Myofascial Neck Pain

Hand Grip StrengthNeck Pain MusculoskeletalTrigger Point in Trapezius Muscle+5 more
Cairo University60 enrolled1 locationNCT07692126
Recruiting
Not Applicable

Ischemic Compression and Home Exercise in Non-Specific Neck Pain

myofascial trigger pointsMusculoskeletal PainNeck Pain+1 more
Istanbul Rumeli University52 enrolled1 locationNCT07685418
Recruiting

Functional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study

musculoskeletal health.SarcopeniaOsteoporosis+1 more
Kanuni Sultan Suleyman Training and Research Hospital200 enrolled1 locationNCT07677033
Recruiting
Not Applicable

Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients

PainOpioidPilot Study+1 more
Massachusetts General Hospital100 enrolled1 locationNCT07265557
Recruiting
Not Applicable

Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE)

Musculoskeletal DiseasesArthritisJoint Diseases+5 more
University of Alberta170 enrolled5 locationsNCT04580225
Recruiting
Not Applicable

Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma

Orthopaedic traumaMusculoskeletal injuryChronic Pain
Johns Hopkins University30 enrolled1 locationNCT05989230
Recruiting
Not Applicable

Weighted Blanket Use for Adults With Chronic Pain

Musculoskeletal PainSleep DisturbanceChronic Pain+1 more
National University of Natural Medicine44 enrolled1 locationNCT07498491
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting
Not Applicable

Video Intervention for Older Adults With Chronic Pain

Musculoskeletal PainChronic PainOlder Adults With Chronic Pain
Butler Hospital100 enrolled1 locationNCT07404618
Recruiting
Not Applicable

Equipping Patients Using Interventions for Pain and Depression

DepressionMusculoskeletal PainChronic Pain+1 more
Indiana University304 enrolled1 locationNCT06500780
Recruiting
Not Applicable

Supraspinal Processing of Sensory Aspects of Pain

Musculoskeletal PainFibromyalgiaFunctional Abdominal Pain Syndrome+2 more
Children's Hospital Medical Center, Cincinnati255 enrolled1 locationNCT05814497
Recruiting

Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in Albanian

Lower Limb InjuryHealthyMusculoskeletal Pain+2 more
Universidad Católica San Antonio de Murcia300 enrolled1 locationNCT06685094
Recruiting
Not Applicable

The PROACTIVE Study for Black Elders

Pain, ChronicMusculoskeletal PainChronic Pain+2 more
University of Florida120 enrolled1 locationNCT06512727
Recruiting
Not Applicable

PRISM: The PRimary Care Individual Social Norms MSK Data Dashboard: a Feasibility Trial

Musculoskeletal Disorders
University College, London60 enrolled2 locationsNCT07112508
Recruiting

Pre- and Post-neuromusculoskeletal Injury Risk Evaluation for Return-to-Duty Enhancement

Musculoskeletal injuries
Womack Army Medical Center2,690 enrolled2 locationsNCT05111925
Recruiting
Phase 4

GLP-1R Actions on Muscle and the Skeleton

ObesityOsteoporosisDrug Effect+2 more
Pennington Biomedical Research Center50 enrolled1 locationNCT07154719