Phase 1 Pain Clinical Trials

121 recruitingPhase 1

What is a Phase 1 trial?

Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.

Showing 120 of 121 trials

Recruiting
Phase 1

Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults

Neuropathic Pain
Alcamena Stem Cell Therapeutics72 enrolled1 locationNCT07363395
Recruiting
Phase 1

Adia Med of Winter Park LLC Lower Back Pain Research Study

Lower back painChronic Lower Back PainChronic Mechanical Lower Back Pain
Adia Med of Winter Park LLC100 enrolled1 locationNCT07587047
Recruiting
Phase 1

Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

Palliative CareIntractable Pain
National Institute of Dental and Craniofacial Research (NIDCR)45 enrolled1 locationNCT00804154
Recruiting
Phase 1

Managing Chronic Tendon Pain by Metformin

Chronic PainAchilles tendinopathyTendinopathy
James Wang40 enrolled1 locationNCT06100822
Recruiting
Phase 1

Effects of Efavirenz on the Pharmacokinetics of Suzetrigine in Healthy Participants

Pain
Vertex Pharmaceuticals Incorporated18 enrolled1 locationNCT07570069
Recruiting
Phase 1

Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy (SBRT) in Participants With Cancer-Related Celiac Pain

Pancreatic CancerRetroperitoneal Pain Syndrome
Case Comprehensive Cancer Center5 enrolled1 locationNCT07117032
Recruiting
Phase 1Phase 2

Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)

Chronic Neuropathic Pain
Sangamo Therapeutics27 enrolled11 locationsNCT06980948
Recruiting
Phase 1

Hormones, Outcomes, and Pain Pathways in Exercise Study

Activity, MotorInflammationChest Pain+10 more
University of Houston140 enrolled1 locationNCT07579182
Recruiting
Phase 1Phase 2

Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease

Post Operative PainUrolithiasisStent Complication+1 more
University of Texas Southwestern Medical Center80 enrolled1 locationNCT06158620
Recruiting
Phase 1

Samarium Optimized for Long-lasting Analgesia in Cancerous End-stage Bone Pain

Bone PainMetastatic Bone TumorBone Metastases in Subjects With Advanced Cancer
Telix Pharmaceuticals (Innovations) Pty Limited33 enrolled6 locationsNCT07197645
Recruiting
Phase 1

Evaluation of the Excretion of Suzetrigine Into Breast Milk in Healthy Lactating Female Participants

Pain
Vertex Pharmaceuticals Incorporated12 enrolled1 locationNCT07378865
Recruiting
Phase 1

STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis

Pancreatic SurgeryChronic PainChronic Pancreatitis+7 more
Indiana University24 enrolled5 locationsNCT05603702
Recruiting
Phase 1Phase 2

Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study

Diabetic NeuropathiesDiabetic Peripheral Neuropathic Pain (DPN)
Florida A&M University20 enrolled1 locationNCT07298408
Recruiting
Phase 1

The Safety/Efficacy Study of Human Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-LDP) for Lumbar Discogenic Pain

Lumbar Discogenic Pain
Sclnow Biotechnology Co., Ltd.242 enrolled1 locationNCT04104412
Recruiting
Phase 1

A Study of HRS-2129 in Patients With Diabetic Peripheral Neuropathic Pain

Diabetic peripheral neuropathic pain
Shandong Suncadia Medicine Co., Ltd.168 enrolled2 locationsNCT07377721
Recruiting
Phase 1

Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis

Chronic PainChronic Pancreatitis
VA Office of Research and Development40 enrolled1 locationNCT05925036
Recruiting
Phase 1

A Study of Single and Multiple Doses of HRS-6257 in Healthy Subjects

Pain
Shanghai Hengrui Pharmaceutical Co., Ltd.80 enrolled1 locationNCT07301333
Recruiting
Phase 1

Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling

Chronic Pain
University of Minnesota30 enrolled1 locationNCT07103135
Recruiting
Phase 1

Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

PainPostpartum Depression
Grace Lim, MD, MS50 enrolled2 locationsNCT06767566
Recruiting
Phase 1Phase 2

Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy

Post Operative Pain in Total Abdominal Hystrectomy
Liaquat National Hospital & Medical College30 enrolled1 locationNCT07482709