Early Phase 1 Pain Clinical Trials
39 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 39 trials
Recruiting
Early Phase 1
Repeated CBD Administration and Cannabis Outcomes
CannabisAbuse LiabilityExperimental Pain in Healthy Human Participants
Hannah Harris23 enrolled1 locationNCT07434895
Recruiting
Early Phase 1
Nitrous Oxide Neuroimaging
PainAnesthesiaAmnesia
Keith M Vogt60 enrolled1 locationNCT06702631
Recruiting
Early Phase 1
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic Low Back Pain (CLBP)SciaticaLumbar Radiculopathy+4 more
University of California, San Diego100 enrolled1 locationNCT04982965
Recruiting
Early Phase 1
Ketamine and Propofol NeuroImaging
PainAnesthesia
Keith M Vogt60 enrolled1 locationNCT07294092
Recruiting
Early Phase 1
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management
Pain, Orofacial
University of Colorado, Denver375 enrolled1 locationNCT04059172
Recruiting
Early Phase 1
A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes
Pain, AcuteBurns
University of Manitoba30 enrolled1 locationNCT03695887
Recruiting
Early Phase 1
Tart Cherry and Omega-3's for Aromatase Inhibitor Musculoskeletal Symptoms
Breast CancerAromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS)Joint Pain
Philip Chang30 enrolled2 locationsNCT06123286
Recruiting
Early Phase 1
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery
PainBrain InjuryBrain Tumors+3 more
University of Virginia40 enrolled1 locationNCT06810336
Recruiting
Early Phase 1
The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
Pain
University of Florida45 enrolled1 locationNCT05761860
Recruiting
Early Phase 1
The Role of NaV1.8 in Human Pain Models
PainHealthy Volunteer StudyAcute Pain
Medical University of Vienna66 enrolled1 locationNCT07511400
Recruiting
Early Phase 1
Nebulized Dexmedetomidine or Lidocaine for Treatment of Post Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia
Pain Score (VAS)
Minia University114 enrolled1 locationNCT06607861
Recruiting
Early Phase 1
Efficacy of a Topical Palmitated Formulation of Capsaicin (Capsadyn®) In the Treatment of Diabetic Neuropathic Foot Pain
Diabetic FootDiabetic Peripheral NeuropathyDiabetic Neuropathies, Painful
Carilion Clinic80 enrolled1 locationNCT07260656
Recruiting
Early Phase 1
Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain
Chronic PainChronic Pancreatitis
Medical University of South Carolina48 enrolled1 locationNCT06205342
Recruiting
Early Phase 1
Cannabidiol in Opioid Use Disorder and Chronic Pain
Chronic PainOpioid-use Disorder
Yale University34 enrolled1 locationNCT04587791
Recruiting
Early Phase 1
Remimazolam NeuroImaging
PainAnesthesiaRemimazolam
Keith M Vogt60 enrolled1 locationNCT07290205
Recruiting
Early Phase 1
Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion
DeliriumPain, BackSpinal Fusion+1 more
University of Iowa50 enrolled1 locationNCT05461092
Recruiting
Early Phase 1
Effects of Dronabinol in Opioid Maintained Patients
Pain
Yale University36 enrolled1 locationNCT04025359
Recruiting
Early Phase 1
Ketamine for Shoulder Pain Following Laparoscopic Gastric Sleeve Surgery
Pain ManagementLaparascopic Sleeve Gastrectomy
King Abdullah University Hospital50 enrolled1 locationNCT07429916
Recruiting
Early Phase 1
PK/PD of Oral and Vaporized Delta-9-Tetrahydrocannabinol (THC) in Older Adults
Pain, ToleranceOral vs Vaporized THCAbuse Liability
Yale University20 enrolled1 locationNCT05906511
Recruiting
Early Phase 1
The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.
Post-endodontic PainMechanical Detection ThresholdMechanical Pain Threshold+1 more
Chattogram International Dental College280 enrolled1 locationNCT07400471