Pleural Mesothelioma Clinical Trials

8 recruiting

Pleural Mesothelioma Trials at a Glance

27 actively recruiting trials for pleural mesothelioma are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Phase 2 with 10 trials, with the heaviest enrollment activity in Houston, Commack, and Aurora. Lead sponsors running pleural mesothelioma studies include AstraZeneca, Memorial Sloan Kettering Cancer Center, and Ankara University.

Browse pleural mesothelioma trials by phase

Treatments under study

About Pleural Mesothelioma Clinical Trials

Looking for clinical trials for Pleural Mesothelioma? There are currently 8 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pleural Mesothelioma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pleural Mesothelioma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 27 trials

Recruiting

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

Thoracic CancersLung Cancer NOSMalignant Pleural Mesotheliomas NOS+2 more
National Cancer Institute (NCI)1,559 enrolled1 locationNCT00242723
Recruiting
Phase 3

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma

Unresectable Pleural Mesothelioma
AstraZeneca825 enrolled178 locationsNCT06097728
Recruiting

Multidimensional Omics Analysis in Malignant Pleural Mesothelioma

Malignant Pleural Mesothelioma (MPM)
Azienda USL Reggio Emilia - IRCCS300 enrolled4 locationsNCT07561190
Recruiting
Phase 1

A Study of BMS-986504 With Standard-of-Care Therapy for People With Solid Tumor Cancer

Urothelial CarcinomaDiffuse Pleural MesotheliomaGastroesophageal Carcinoma
Memorial Sloan Kettering Cancer Center60 enrolled7 locationsNCT07532902
Recruiting
Phase 1Phase 2

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

MelanomaAdvanced Solid TumorMetastasis+5 more
7 Hills Pharma, LLC126 enrolled5 locationsNCT06362369
Recruiting
Phase 1

A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors

Gastric AdenocarcinomaBladder CancerMesothelioma+7 more
IDEAYA Biosciences260 enrolled10 locationsNCT07277413
Recruiting
Phase 1Phase 2

Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma

Malignant Pleural Mesotheliomas
Beijing Biotech36 enrolled1 locationNCT07510815
Recruiting
Not Applicable

Hemithoracic Irradiation With Proton Therapy in Malignant Pleural Mesothelioma

Malignant Pleural Mesothelioma
University College, London148 enrolled25 locationsNCT05655078
Recruiting
Phase 2

Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors

Sub-study 1 Cervical Cancer (Volrustomig Monotherapy)Sub-study 2 Head and Neck Squamous Cell Carcinoma (Volrustomig Monotherapy)Sub-study 3 Head and Neck Squamous Cell Carcinoma (Volrustomig in Combination With Chemotherapy)+2 more
AstraZeneca257 enrolled59 locationsNCT06535607
Recruiting
Phase 2

Evaluating Ivonescimab as a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and Chemotherapy

Pleural Mesotheliomas
Intergroupe Francophone de Cancerologie Thoracique38 enrolled20 locationsNCT06840834
Recruiting
Not Applicable

INTEGRATIVE "MULTI-OMICS" AND FUNCTIONAL PLATFORM FOR THE COMPLETE DIAGNOSTIC CHARACTERIZATION OF TUMORS: THE ITALIAN TUMOR CHEMOGENOMIC PROFILER (IT-TCP)

Pancreatic CancerOvarian CancerMelanoma+9 more
Azienda Ospedaliero-Universitaria di Parma300 enrolled2 locationsNCT07403630
Recruiting
Phase 2

The IMmunotherapy Pleural 5-ALA PDT

Malignant Pleural MesotheliomaMesotheliomas Pleural
University Hospital, Lille20 enrolled1 locationNCT04400539
Recruiting
Not Applicable

Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma

Malignant Pleural Mesothelioma
Memorial Sloan Kettering Cancer Center20 enrolled7 locationsNCT06037941
Recruiting
Phase 1

A Study of NX-1607 in Adults With Advanced Malignancies

Gastric CancerNon-small Cell Lung Cancer (NSCLC)Head and Neck Squamous Cell Carcinoma+5 more
Nurix Therapeutics, Inc.345 enrolled17 locationsNCT05107674
Recruiting

TTFields in General Routine Clinical Care in Patients With Pleural Mesothelioma Study

Pleural Mesothelioma
NovoCure Ltd.198 enrolled23 locationsNCT05538806
Recruiting
Phase 1

CT-95 in Advanced Cancers Associated With Mesothelin Expression

Mesothelin-Expressing TumorsEpithelial Ovarian CancerLung Adenocarcinoma Metastatic+7 more
Context Therapeutics Inc.70 enrolled8 locationsNCT06756035
Recruiting
Phase 2

The Diagnostic Accuracy and Clinical Value of FAPI PET in Pleural Mesothelioma

CancerPleural MesotheliomaPleural Diseases+2 more
Aalborg University Hospital70 enrolled1 locationNCT06790082
Recruiting
Phase 2

Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma

Malignant Pleural Mesothelioma
Hyogo Medical University25 enrolled1 locationNCT06318286
Recruiting
Not Applicable

Hemithoracic Arc Radiotherapy Post Pleural Decortication

Malignant Pleural Mesothelioma
Cairo University45 enrolled1 locationNCT06910449
Recruiting
Phase 2

Multicenter Single-Arm Study of Ivonescimab (AK112) Combined with Chemotherapy in Pretreated Pleural Mesothelioma

Pretreated Pleural Mesothelioma
The First Hospital of Jilin University25 enrolled1 locationNCT06875076