Preserved Ejection Fraction Clinical Trials

2 recruiting

Frequently Asked Questions

Common questions about Preserved Ejection Fraction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 110 trials

Recruiting

The Use of Advanced Imaging in HFpEF

Heart Failure With Preserved Ejection Fraction (HFpEF)
Sheffield Teaching Hospitals NHS Foundation Trust40 enrolled2 locationsNCT06905405
Recruiting
Not Applicable

Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF

Atrial Fibrillation (AF)Atrioventricular BlockPacemaker Therapy+1 more
University Hospital of Patras244 enrolled1 locationNCT07250529
Recruiting
Not Applicable

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

Heart Failure With Preserved Ejection Fraction (HFpEF)
Axon Therapies, Inc.150 enrolled20 locationsNCT04592445
Recruiting

AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices

Cardiovascular DiseasesHeart Failure With Preserved Ejection Fraction (HFpEF)Heart Failure With Reduced Ejection Fraction (HFrEF)+2 more
University of Salerno205 enrolled1 locationNCT06909682
Recruiting

Prospective Evaluation of AI-ECG for SHD Detection

Heart Failure With Preserved Ejection Fraction (HFpEF; Diagnosis)Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)Pulmonary Hypertension (Diagnosis)+1 more
Imperial College London590 enrolled5 locationsNCT07057466
Recruiting

Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System

Heart FailureHeart Failure With Reduced Ejection FractionHeart Failure NYHA Class IV+1 more
Yale University40,000 enrolled1 locationNCT04237701
Recruiting
Not Applicable

ELEVATE-HFpEF Clinical Study

Heart Failure With Preserved Ejection Fraction (HFpEF)
Medtronic Cardiac Rhythm and Heart Failure700 enrolled28 locationsNCT06678841
Recruiting
Phase 3

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

ObesityHeart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection Fraction
Amgen5,056 enrolled564 locationsNCT07037459
Recruiting

A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD

Coronary Microvascular DysfunctionHeart Failure With Preserved Ejection Fraction
Mayo Clinic25 enrolled1 locationNCT07093528
Recruiting
Phase 1

A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Heart Failure With Preserved Ejection Fraction (HFpEF)Heart
Vasa Therapeutics42 enrolled17 locationsNCT07219511
Recruiting
Phase 4

Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)

Iron-deficiencyHeart Failure With Preserved Ejection Fraction
Massachusetts General Hospital66 enrolled1 locationNCT04945707
Recruiting
Not Applicable

Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication

Atrial Fibrillation (AF)Heart Failure With Preserved Ejection Fraction (HFpEF)Heart Failure With Mildly Reduced Ejection Fraction+2 more
Nova Scotia Health Authority84 enrolled1 locationNCT07272902
Recruiting
Not Applicable

Can Tiny Bubbles Offer an Alternative to Catheters for Assessing Pressures Inside the Heart? Investigating Ultrasound Contrast Agents as Pressure Sensors Against Gold Standard Catheter Pressures in Cardiac Catheterisation Patients.

Heart DiseaseHFpEF - Heart Failure With Preserved Ejection FractionCardiac Catheterisation
King's College London10 enrolled1 locationNCT07416279
Recruiting
Not Applicable

Transitions of Care Clinic (TOCC)

Heart Failure With Preserved Ejection Fraction
Hackensack Meridian Health150 enrolled1 locationNCT06937827
Recruiting

Heart Failure With Preserved Ejection Fraction in Patients With Сhronic Obstructive Pulmonary Disease: Clinical Course and Prognosis

COPD, Chronic Obstructive Pulmonary DiseaseHeart Failure With Preserved Ejection Fraction (HFpEF; Diagnosis)
National Medical Research Center for Therapy and Preventive Medicine200 enrolled2 locationsNCT07375433
Recruiting

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction
Mayo Clinic400 enrolled1 locationNCT07401771
Recruiting
Phase 2

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

Pulmonary HypertensionHeart Failure With Preserved Ejection Fraction
Tectonic Therapeutic180 enrolled86 locationsNCT06616974
Recruiting
Not Applicable

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection FractionConcentric Hypertrophy
Medtronic Cardiac Rhythm and Heart Failure105 enrolled9 locationsNCT05839730
Recruiting
Phase 2

Allopurinol Improves Heart Function in African Americans With Resistant Hypertension

Heart Failure Preserved Ejection FractionResistant Hypertension
VA Office of Research and Development50 enrolled1 locationNCT05888233
Recruiting
Phase 2

Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension

HFrEF - Heart Failure With Reduced Ejection FractionHFpEF - Heart Failure With Preserved Ejection FractionGroup 2 Pulmonary Hypertension
Salubris Biotherapeutics Inc30 enrolled1 locationNCT07221513