Sclerosis Clinical Trials

979 recruitingLast updated: June 18, 2026

There are 979 actively recruiting sclerosis clinical trials across 78 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Boston, Massachusetts, United States, Chicago, Illinois, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Sclerosis Trials at a Glance

979 actively recruiting trials for sclerosis are listed on ClinicalTrialsFinder across 6 cities in 78 countries. The largest study group is Not Applicable with 322 trials, with the heaviest enrollment activity in Boston, Chicago, and New York. Lead sponsors running sclerosis studies include Novartis Pharmaceuticals, Assistance Publique - Hôpitaux de Paris, and Istituto Auxologico Italiano.

Treatments under study

About Sclerosis Clinical Trials

Looking for clinical trials for Sclerosis? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Sclerosis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Sclerosis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 979 trials

Recruiting
Phase 1

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmRheumatoid Arthritis+11 more
National Cancer Institute (NCI)300 enrolled52 locationsNCT03816345
Recruiting
Phase 2

An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis

Focal Segmental Glomerulosclerosis
National Human Genome Research Institute (NHGRI)30 enrolled1 locationNCT06664814
Recruiting

Familial Investigations of Childhood Cancer Predisposition

Pancreatic CancerHereditary Breast and Ovarian CancerHodgkin Lymphoma+43 more
St. Jude Children's Research Hospital1,500 enrolled1 locationNCT03050268
Recruiting

ASSESS ALL ALS Study

Amyotrophic Lateral Sclerosis
St. Joseph's Hospital and Medical Center, Phoenix2,000 enrolled32 locationsNCT06578195
Recruiting

PREVENT ALL ALS Study

Amyotrophic Lateral Sclerosis
St. Joseph's Hospital and Medical Center, Phoenix600 enrolled32 locationsNCT06581861
Recruiting
Not Applicable

Diagnostic Value of eVOG

Multiple SclerosisRadiologically Isolated SyndromeWhite Matter Lesions
Centre Hospitalier Universitaire de Nice150 enrolled1 locationNCT05776511
Recruiting
Not Applicable

Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

Arterial Occlusive DiseasesPainCardiovascular Diseases+12 more
Teleflex1,859 enrolled1 locationNCT07258290
Recruiting
Not Applicable

Motor Learning of Fall Resistant Skills Through Slip and Trip Exposure in Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting
Georgia State University64 enrolled1 locationNCT06919900
Recruiting
Phase 3

A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

Multiple Sclerosis (MS) Primary Progressive
Zenas BioPharma (USA), LLC705 enrolled12 locationsNCT07067463
Recruiting

Role of Genetic Factors in the Development of Lung Disease

AsthmaCystic FibrosisPulmonary Fibrosis+2 more
National Heart, Lung, and Blood Institute (NHLBI)3,500 enrolled2 locationsNCT00001532
Recruiting

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

ObesityCardiomyopathyLi-Fraumeni Syndrome+3 more
National Heart, Lung, and Blood Institute (NHLBI)5,000 enrolled3 locationsNCT01143454
Recruiting

Cohort Study on Neuroimmune Diseases in the Reproductive Age

Myasthenia GravisAutoimmune EncephalitisMultiple Sclerosis+3 more
Third Affiliated Hospital, Sun Yat-Sen University100 enrolled1 locationNCT07653984
Recruiting

Study of the Disease Process of Lymphangioleiomyomatosis

PneumothoraxLymphangioleiomyomatosisLung Disease+1 more
National Heart, Lung, and Blood Institute (NHLBI)2,000 enrolled1 locationNCT00001465
Recruiting
Phase 1Phase 2

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

Multiple Sclerosis
National Institute of Allergy and Infectious Diseases (NIAID)250 enrolled1 locationNCT03109288
Recruiting

Causes and Natural History of Dyslipidemias

AtherosclerosisHypercholesterolemia
National Heart, Lung, and Blood Institute (NHLBI)2,000 enrolled1 locationNCT00353782
Recruiting

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic Lateral SclerosisFrontotemporal DementiaProgressive Supranuclear Palsy
National Institute of Neurological Disorders and Stroke (NINDS)360 enrolled1 locationNCT03225144
Recruiting
Phase 2

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

Chronic respiratory failureNon-invasive ventilationRespiratory Insufficiency+7 more
University of Pennsylvania48 enrolled3 locationsNCT07071935
Recruiting

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

Multiple Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)3,750 enrolled1 locationNCT00001248
Recruiting

Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)

MRIMultiple SclerosisNMO Spectrum Disorder+1 more
Beijing Tiantan Hospital1,000 enrolled1 locationNCT04106830
Recruiting
Phase 2

Dazucorilant in Patients With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis
Corcept Therapeutics279 enrolled35 locationsNCT05407324