Phase 1 Soft Tissue Sarcoma Clinical Trials
24 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 24 trials
Recruiting
Phase 1
Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization
Soft Tissue SarcomaMelanoma
University of Florida18 enrolled1 locationNCT05264974
Recruiting
Phase 1Phase 2
Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma
Soft Tissue SarcomaSarcomaSarcoma,Soft Tissue+1 more
Memorial Sloan Kettering Cancer Center98 enrolled1 locationNCT04577014
Recruiting
Phase 1
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
Soft Tissue SarcomaMelanomaCarcinoma+13 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT04897321
Recruiting
Phase 1Phase 2
Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma
Metastatic Soft Tissue SarcomaMetastatic LeiomyosarcomaAdvanced Soft Tissue Sarcoma+5 more
National Cancer Institute (NCI)74 enrolled1 locationNCT06498648
Recruiting
Phase 1Phase 2
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma
Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting
Phase 1
Actinium Therapy for Late-stage Aggressive Sarcomas
Advanced Soft Tissue Sarcoma
Ratio Therapeutics, Inc.30 enrolled6 locationsNCT07156565
Recruiting
Phase 1Phase 2
Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases
Resectable SarcomaMetastatic Malignant Neoplasm in the LungMetastatic Bone Sarcoma+2 more
Roswell Park Cancer Institute99 enrolled1 locationNCT03965234
Recruiting
Phase 1
Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas
SarcomaEwing SarcomaChildhood Soft Tissue Sarcoma+2 more
St. Jude Children's Research Hospital42 enrolled1 locationNCT07222735
Recruiting
Phase 1
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
Breast CancerUrothelial CarcinomaSoft Tissue Sarcoma+2 more
Avacta Life Sciences Ltd158 enrolled9 locationsNCT04969835
Recruiting
Phase 1Phase 2
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma
Metastatic Soft Tissue SarcomaUnresectable Soft Tissue Sarcoma
Adcendo ApS270 enrolled8 locationsNCT06797999
Recruiting
Phase 1
HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma
Soft Tissue SarcomaSarcomaOsteosarcoma+5 more
Baylor College of Medicine25 enrolled1 locationNCT04995003
Recruiting
Phase 1Phase 2
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Breast CancerEsophageal CancerGastric Cancer+13 more
Tanabe Pharma America, Inc.27 enrolled6 locationsNCT06943521
Recruiting
Phase 1
In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma
Soft Tissue SarcomaBone SarcomaPulmonary Metastases
University Health Network, Toronto17 enrolled1 locationNCT02811523
Recruiting
Phase 1
A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma
Soft Tissue SarcomaBone Sarcoma
M.D. Anderson Cancer Center40 enrolled1 locationNCT05621668
Completed
Phase 1
A green tea-pazopanib pharmacokinetic interaction study in healthy participants
Soft Tissue Sarcoma
The University of Sydney15 enrolled1 locationACTRN12625000814471
Recruiting
Phase 1
Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Recurrent Childhood Lymphoblastic LymphomaRecurrent Childhood Acute Myeloid LeukemiaRefractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive+15 more
Florida International University65 enrolled1 locationNCT05857969
Recruiting
Phase 1
Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants
Soft Tissue SarcomaMelanomaEwing Sarcoma+2 more
Iovance Biotherapeutics, Inc.40 enrolled5 locationsNCT06566092
Recruiting
Phase 1Phase 2
SAINT:Trabectedin, Ipilimumab and Nivolumab for Previously Treated Advanced Soft Tissue Sarcoma
Metastatic Soft Tissue SarcomaAdvanced Soft Tissue Sarcoma
Sarcoma Oncology Research Center, LLC250 enrolled1 locationNCT03138161
Recruiting
Phase 1
89Zr-olaratumab Dosimetry in Participants With Soft Tissue Sarcoma
Soft Tissue Sarcoma
Telix Pharmaceuticals (Innovations) Pty Ltd50 enrolled1 locationNCT06537596
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
Advanced Solid TumorMetastatic Solid TumorSoft Tissue Sarcoma (STS)+3 more
GI Innovation, Inc.358 enrolled11 locationsNCT05824975