Phase 1 Surgery Clinical Trials
19 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–19 of 19 trials
Recruiting
Phase 1
Study of LGW16-03 To Identify Nerves
AdultsOpen-field SurgeryMajor Nerve
Eric R. Henderson38 enrolled1 locationNCT07385430
Recruiting
Phase 1
Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS)
Weight LossAlcohol Use DisorderBariatric Surgery Patients
Yale University10 enrolled1 locationNCT07223983
Recruiting
Phase 1
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Pancreatic SurgeryChronic PainChronic Pancreatitis+7 more
Indiana University24 enrolled5 locationsNCT05603702
Recruiting
Phase 1
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
SurgeryPostoperative Blood Loss
Vanderbilt University Medical Center60 enrolled1 locationNCT05774717
Recruiting
Phase 1Phase 2
Topical Infliximab in Eyes With Penetrating Keratoplasty
Glaucoma Following Surgery
Centre hospitalier de l'Université de Montréal (CHUM)50 enrolled1 locationNCT05180994
Recruiting
Phase 1Phase 2
Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children
Mechanical VentilationCongenital Heart DiseaseChildren+8 more
Charite University, Berlin, Germany80 enrolled1 locationNCT07193719
Recruiting
Phase 1
Intestinal Microbiota Transplantation in Patients Undergoing Colon Resection
Recurrent Clostridioides difficile infectionColonic Surgery
University of Minnesota40 enrolled1 locationNCT06370884
Recruiting
Phase 1
Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
ObesitySmoking CessationBariatric Surgery Patients
Yale University20 enrolled1 locationNCT07224087
Recruiting
Phase 1
Neoadjuvant Darolutamide and Relugolix Combination Preceding Radical Prostatectomy for Prostate Cancer
Prostate Cancer SurgeryProstate Cancer (Adenocarcinoma)Prostate CA
AdventHealth30 enrolled1 locationNCT06631521
Recruiting
Phase 1
Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents
ObesityBariatric SurgeryAdolescent Obesity+3 more
University of Colorado, Denver40 enrolled1 locationNCT06575738
Recruiting
Phase 1Phase 2
Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial
Critical IllnessThoracic SurgeryPost-operative Complication
Wandercraft5 enrolled1 locationNCT07220733
Recruiting
Phase 1Phase 2
Propranolol Treatment for Postoperative Chylothorax
Open-heart surgeryCongenital Heart DiseaseChylothorax+1 more
June Wu50 enrolled1 locationNCT06833320
Recruiting
Phase 1
An Open-Label, Pilot Clinical Trial To Test The Safety And Feasibility Of A Suspension of Freeze-dried Microbiota In Patients Undergoing Colon Resection
Recurrent Clostridioides difficile infectionColonic Surgery
University of Minnesota40 enrolled1 locationNCT06692179
Recruiting
Phase 1Phase 2
Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric Population
Enhanced Recovery After Surgery in a Pediatric Population
University of Chicago100 enrolled1 locationNCT06538584
Recruiting
Phase 1Phase 2
Double-blind Pilot Study on the Effect of Anionic Exposome Enrichment (Biow) on Recovery and Sleep Quality in Postoperative Patients
Postoperative RecoveryInflammatory Response After Surgery
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz150 enrolled1 locationNCT06968000
Recruiting
Phase 1
Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds
Wound HealingMohs Micrographic Surgery
Icahn School of Medicine at Mount Sinai102 enrolled1 locationNCT06941467
Recruiting
Phase 1Phase 2
Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant
Hepatocellular Carcinoma (HCC)Liver Transplant SurgeryMacrovascular Invasion+1 more
University Health Network, Toronto48 enrolled2 locationsNCT06725121
Completed
Phase 1
A pilot randomised open-label taste-testing study to evaluate the acceptability of chocolate-based tramadol in children
Pain management in relation to surgery
Princess Margaret Hospital150 enrolled2 locationsACTRN12617001490369
Completed
Phase 1
A Phase 1 Study of a Novel Bi-Directional Arterial Cannula in Patients requiring Peripheral Cannulation for Cardiac Surgery.
Patients who require peripheral cannulation for cardiac surgery.
Alfred Hospital15 enrolled1 locationACTRN12615001008516